tetano
Editor, Senior Moderator
Sci Rep
. 2024 Mar 19;14(1):6539.
doi: 10.1038/s41598-024-57306-5. Clinical and laboratory characteristics of patients hospitalized with severe COVID-19 in New Orleans, August 2020 to September 2021
Arnaud Drouin[SUP] 1 2 [/SUP], Ian D Plumb[SUP] 3 [/SUP], Matthew McCullough[SUP] 4 [/SUP], Jade James Gist[SUP] 4 [/SUP], Sharon Liu[SUP] 1 [/SUP], Marc Theberge[SUP] 1 [/SUP], Joshua Katz[SUP] 1 [/SUP], Matthew Moreida[SUP] 1 [/SUP], Shelby Flaherty[SUP] 5 [/SUP], Bhoomija Chatwani[SUP] 5 [/SUP], Melissa Briggs Hagen[SUP] 3 [/SUP], Claire M Midgley[SUP] 3 [/SUP], Dahlene Fusco[SUP] 6 7 8 [/SUP]
Affiliations
Louisiana experienced high morbidity and mortality from COVID-19. To assess possible explanatory factors, we conducted a cohort study (ClinSeqSer) of patients hospitalized with COVID-19 in New Orleans during August 2020-September 2021. Following enrollment, we reviewed medical charts, and performed SARS-CoV-2 RT-PCR testing on nasal and saliva specimens. We used multivariable logistic regression to assess associations between patient characteristics and severe illness, defined as ≥ 6 L/min oxygen or intubation. Among 456 patients, median age was 56 years, 277 (60.5%) were Black non-Hispanic, 436 (95.2%) had underlying health conditions, and 358 were unvaccinated (92.0% of 389 verified). Overall, 187 patients (40.1%) had severe illness; 60 (13.1%) died during admission. In multivariable models, severe illness was associated with age ≥ 65 years (OR 2.08, 95% CI 1.22-3.56), hospitalization > 5 days after illness onset (OR 1.49, 95% CI 1.01-2.21), and SARS CoV-2 cycle threshold (Ct) result of < 32 in saliva (OR 4.79, 95% CI 1.22-18.77). Among patients who were predominantly Black non-Hispanic, unvaccinated and with underlying health conditions, approximately 1 in 3 patients had severe COVID-19. Older age and delayed time to admission might have contributed to high case-severity. An association between case-severity and low Ct value in saliva warrants further investigation.
Keywords: Anti-N antibody; COVID-19; SARS CoV-2; qRT-PCR.
. 2024 Mar 19;14(1):6539.
doi: 10.1038/s41598-024-57306-5. Clinical and laboratory characteristics of patients hospitalized with severe COVID-19 in New Orleans, August 2020 to September 2021
Arnaud Drouin[SUP] 1 2 [/SUP], Ian D Plumb[SUP] 3 [/SUP], Matthew McCullough[SUP] 4 [/SUP], Jade James Gist[SUP] 4 [/SUP], Sharon Liu[SUP] 1 [/SUP], Marc Theberge[SUP] 1 [/SUP], Joshua Katz[SUP] 1 [/SUP], Matthew Moreida[SUP] 1 [/SUP], Shelby Flaherty[SUP] 5 [/SUP], Bhoomija Chatwani[SUP] 5 [/SUP], Melissa Briggs Hagen[SUP] 3 [/SUP], Claire M Midgley[SUP] 3 [/SUP], Dahlene Fusco[SUP] 6 7 8 [/SUP]
Affiliations
- PMID: 38503862
- DOI: 10.1038/s41598-024-57306-5
Louisiana experienced high morbidity and mortality from COVID-19. To assess possible explanatory factors, we conducted a cohort study (ClinSeqSer) of patients hospitalized with COVID-19 in New Orleans during August 2020-September 2021. Following enrollment, we reviewed medical charts, and performed SARS-CoV-2 RT-PCR testing on nasal and saliva specimens. We used multivariable logistic regression to assess associations between patient characteristics and severe illness, defined as ≥ 6 L/min oxygen or intubation. Among 456 patients, median age was 56 years, 277 (60.5%) were Black non-Hispanic, 436 (95.2%) had underlying health conditions, and 358 were unvaccinated (92.0% of 389 verified). Overall, 187 patients (40.1%) had severe illness; 60 (13.1%) died during admission. In multivariable models, severe illness was associated with age ≥ 65 years (OR 2.08, 95% CI 1.22-3.56), hospitalization > 5 days after illness onset (OR 1.49, 95% CI 1.01-2.21), and SARS CoV-2 cycle threshold (Ct) result of < 32 in saliva (OR 4.79, 95% CI 1.22-18.77). Among patients who were predominantly Black non-Hispanic, unvaccinated and with underlying health conditions, approximately 1 in 3 patients had severe COVID-19. Older age and delayed time to admission might have contributed to high case-severity. An association between case-severity and low Ct value in saliva warrants further investigation.
Keywords: Anti-N antibody; COVID-19; SARS CoV-2; qRT-PCR.