tetano
Editor, Senior Moderator
Sci Rep
. 2025 Jul 1;15(1):21348.
doi: 10.1038/s41598-025-05919-9. Association of DHEAS levels with COVID19 severity, gender, age, comorbidities, and management strategies
Tahereh Jamali[SUP] 1 [/SUP], Sussan Kaboudanian Ardestani[SUP] 2 [/SUP], Mohammad-Reza Vaez-Mahdavi[SUP] 3 4 [/SUP], Arezou Rezaei[SUP] 5 [/SUP], Mohammad Mehdi Naghizadeh[SUP] 6 [/SUP], Fatemeh Tuserkani[SUP] 1 [/SUP], HosseinAli Khazaei[SUP] 7 [/SUP], Ali Khodadadi[SUP] 8 9 [/SUP], Bahman Khazaei[SUP] 7 [/SUP], Keivan Latifi[SUP] 10 [/SUP], Tooba Ghazanfari[SUP] 11 12 [/SUP]
Affiliations
COVID-19 has globally impacted millions. This study investigates DHEAS (dehydroepiandrosterone sulfate) as a factor for COVID-19 progression, analyzing its relationship with disease status, temporal patterns, age, gender, and comorbidities to improve outcomes. DHEAS was quantified with a competitive chemiluminescent immunoassay. We conducted DHEAS analysis across different days. COVID-19 patients, particularly inpatients, have lower DHEAS levels compared to controls. DHEAS levels in COVID-19 patients showed a dynamic pattern, with an initial decline followed by recovery. The scatter plot analysis suggested COVID-19 could increase the age-related decline in DHEAS among males. Comorbidities, including hypertension, heart disease, and diabetes mellitus, were prevalent among COVID-19 patients and correlated with disease severity. Hypertension moderated the relationship between hospitalization and DHEAS, especially in females. Our findings showed a significant association between lower DHEAS and COVID-19 severity, along with temporal dynamics. COVID-19's potential to increase the age-related decline in DHEAS, especially in males, underscores its intricate relationship with age. Hypertension's influence on DHEAS suggests a gender-specific effect, emphasizing tailored management approaches. These findings offer valuable insights into the interaction between COVID-19, hormonal dynamics, and demographic factors, suggesting that DHEAS levels may play a role in the pathophysiology of the disease and could be considered alongside other markers.
Keywords: COVID-19; Comorbidity diseases; DHEAS; Inpatients; Outpatients.
. 2025 Jul 1;15(1):21348.
doi: 10.1038/s41598-025-05919-9. Association of DHEAS levels with COVID19 severity, gender, age, comorbidities, and management strategies
Tahereh Jamali[SUP] 1 [/SUP], Sussan Kaboudanian Ardestani[SUP] 2 [/SUP], Mohammad-Reza Vaez-Mahdavi[SUP] 3 4 [/SUP], Arezou Rezaei[SUP] 5 [/SUP], Mohammad Mehdi Naghizadeh[SUP] 6 [/SUP], Fatemeh Tuserkani[SUP] 1 [/SUP], HosseinAli Khazaei[SUP] 7 [/SUP], Ali Khodadadi[SUP] 8 9 [/SUP], Bahman Khazaei[SUP] 7 [/SUP], Keivan Latifi[SUP] 10 [/SUP], Tooba Ghazanfari[SUP] 11 12 [/SUP]
Affiliations
- PMID: 40594737
- PMCID: PMC12217539
- DOI: 10.1038/s41598-025-05919-9
COVID-19 has globally impacted millions. This study investigates DHEAS (dehydroepiandrosterone sulfate) as a factor for COVID-19 progression, analyzing its relationship with disease status, temporal patterns, age, gender, and comorbidities to improve outcomes. DHEAS was quantified with a competitive chemiluminescent immunoassay. We conducted DHEAS analysis across different days. COVID-19 patients, particularly inpatients, have lower DHEAS levels compared to controls. DHEAS levels in COVID-19 patients showed a dynamic pattern, with an initial decline followed by recovery. The scatter plot analysis suggested COVID-19 could increase the age-related decline in DHEAS among males. Comorbidities, including hypertension, heart disease, and diabetes mellitus, were prevalent among COVID-19 patients and correlated with disease severity. Hypertension moderated the relationship between hospitalization and DHEAS, especially in females. Our findings showed a significant association between lower DHEAS and COVID-19 severity, along with temporal dynamics. COVID-19's potential to increase the age-related decline in DHEAS, especially in males, underscores its intricate relationship with age. Hypertension's influence on DHEAS suggests a gender-specific effect, emphasizing tailored management approaches. These findings offer valuable insights into the interaction between COVID-19, hormonal dynamics, and demographic factors, suggesting that DHEAS levels may play a role in the pathophysiology of the disease and could be considered alongside other markers.
Keywords: COVID-19; Comorbidity diseases; DHEAS; Inpatients; Outpatients.