tetano
Editor, Senior Moderator
Sci Rep
. 2024 May 27;14(1):12139.
doi: 10.1038/s41598-024-62899-y. Association between lipid profile and clinical outcomes in COVID-19 patients
Luis Antonio Ochoa-Ramírez[SUP] 1 [/SUP], Alberto Kousuke De la Herrán Arita[SUP] 2 [/SUP], Jorge Guillermo Sanchez-Zazueta[SUP] 3 [/SUP], Efrén Ríos-Burgueño[SUP] 4 [/SUP], Joel Murillo-Llanes[SUP] 5 [/SUP], Luis Adrián De Jesús-González[SUP] 6 [/SUP], Carlos Noe Farfan-Morales[SUP] 7 [/SUP], Carlos Daniel Cordero-Rivera[SUP] 8 [/SUP], Rosa María Del Ángel[SUP] 8 [/SUP], Alejandra Romero-Utrilla[SUP] 9 [/SUP], Josué Camberos-Barraza[SUP] 2 [/SUP], Marco Antonio Valdez-Flores[SUP] 2 [/SUP], Alejandro Camacho-Zamora[SUP] 2 [/SUP], José Candelario Batiz-Beltrán[SUP] 2 [/SUP], Carla Angulo-Rojo[SUP] 2 [/SUP], Alma Marlene Guadrón-Llanos[SUP] 2 [/SUP], Verónica Judith Picos-Cárdenas[SUP] 2 [/SUP], Claudia Desiree Norzagaray-Valenzuela[SUP] 3 [/SUP], Ángel Radamés Rábago-Monzón[SUP] 2 [/SUP], Jesús Salvador Velarde-Félix[SUP] 1 3 [/SUP], José Manuel Reyes-Ruiz[SUP] 10 11 [/SUP], Juan Fidel Osuna-Ramos[SUP] 12 [/SUP]
Affiliations
High-density lipoprotein cholesterol (HDL-c) removes cholesterol, an essential component in lipid rafts, and this cholesterol removal can regulate protein attachment to lipid rafts, modulating their functionality in the immune cell response. Although severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can alter the lipid profile, there is little information on the role of HDL-c and other lipids in prognostic of the coronavirus disease 2019 (COVID-19) in Mexican population. This study aims to evaluate the predictive value of HDL-c and lipid profile on severity and survival of 102 patients infected with SARS-CoV-2 during the COVID-19 first wave. Our findings, derived from univariate and multivariate Cox proportional hazards regression models, highlighted age and hypertension as significant predictors of survival (HR = 1.04, p = 0.012; HR = 2.78, p = 0.027), while gender, diabetes, and obesity showed no significant impact. Triglycerides and HDL-c levels notably influenced mortality, with elevated triglycerides and lower HDL-c associated with higher mortality risk (p = 0.032). This study underscores the importance of lipid profiles alongside traditional risk factors in assessing COVID-19 risk and outcomes. It contributes to the understanding of COVID-19 patient management and emphasizes the need for further investigation into the role of dyslipidemia in influencing COVID-19 prognosis, potentially aiding in refined risk stratification and therapeutic strategies.
Keywords: Biomarker; COVID-19 severity; HDL cholesterol; SARS-CoV-2.
. 2024 May 27;14(1):12139.
doi: 10.1038/s41598-024-62899-y. Association between lipid profile and clinical outcomes in COVID-19 patients
Luis Antonio Ochoa-Ramírez[SUP] 1 [/SUP], Alberto Kousuke De la Herrán Arita[SUP] 2 [/SUP], Jorge Guillermo Sanchez-Zazueta[SUP] 3 [/SUP], Efrén Ríos-Burgueño[SUP] 4 [/SUP], Joel Murillo-Llanes[SUP] 5 [/SUP], Luis Adrián De Jesús-González[SUP] 6 [/SUP], Carlos Noe Farfan-Morales[SUP] 7 [/SUP], Carlos Daniel Cordero-Rivera[SUP] 8 [/SUP], Rosa María Del Ángel[SUP] 8 [/SUP], Alejandra Romero-Utrilla[SUP] 9 [/SUP], Josué Camberos-Barraza[SUP] 2 [/SUP], Marco Antonio Valdez-Flores[SUP] 2 [/SUP], Alejandro Camacho-Zamora[SUP] 2 [/SUP], José Candelario Batiz-Beltrán[SUP] 2 [/SUP], Carla Angulo-Rojo[SUP] 2 [/SUP], Alma Marlene Guadrón-Llanos[SUP] 2 [/SUP], Verónica Judith Picos-Cárdenas[SUP] 2 [/SUP], Claudia Desiree Norzagaray-Valenzuela[SUP] 3 [/SUP], Ángel Radamés Rábago-Monzón[SUP] 2 [/SUP], Jesús Salvador Velarde-Félix[SUP] 1 3 [/SUP], José Manuel Reyes-Ruiz[SUP] 10 11 [/SUP], Juan Fidel Osuna-Ramos[SUP] 12 [/SUP]
Affiliations
- PMID: 38802549
- DOI: 10.1038/s41598-024-62899-y
High-density lipoprotein cholesterol (HDL-c) removes cholesterol, an essential component in lipid rafts, and this cholesterol removal can regulate protein attachment to lipid rafts, modulating their functionality in the immune cell response. Although severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can alter the lipid profile, there is little information on the role of HDL-c and other lipids in prognostic of the coronavirus disease 2019 (COVID-19) in Mexican population. This study aims to evaluate the predictive value of HDL-c and lipid profile on severity and survival of 102 patients infected with SARS-CoV-2 during the COVID-19 first wave. Our findings, derived from univariate and multivariate Cox proportional hazards regression models, highlighted age and hypertension as significant predictors of survival (HR = 1.04, p = 0.012; HR = 2.78, p = 0.027), while gender, diabetes, and obesity showed no significant impact. Triglycerides and HDL-c levels notably influenced mortality, with elevated triglycerides and lower HDL-c associated with higher mortality risk (p = 0.032). This study underscores the importance of lipid profiles alongside traditional risk factors in assessing COVID-19 risk and outcomes. It contributes to the understanding of COVID-19 patient management and emphasizes the need for further investigation into the role of dyslipidemia in influencing COVID-19 prognosis, potentially aiding in refined risk stratification and therapeutic strategies.
Keywords: Biomarker; COVID-19 severity; HDL cholesterol; SARS-CoV-2.