tetano
Editor, Senior Moderator
Sci Rep
. 2022 Sep 24;12(1):15947.
doi: 10.1038/s41598-022-20335-z.
A nationwide cohort study of the association of benzodiazepines with SARS-CoV-2 infection and clinical outcomes
Hye Yoon Park[SUP] #[/SUP][SUP] 1 2 [/SUP], Junhyun Kwon[SUP] #[/SUP][SUP] 3 [/SUP], Suk Kyoon An[SUP] 4 5 6 [/SUP], Eun-Cheol Park[SUP] 7 8 [/SUP]
Affiliations
Abstract
The evidence for the impact of benzodiazepine (BZD) use on infection or clinical outcomes of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is limited. We evaluated the association of BZD use with SARS-CoV-2 infection and the clinical outcomes of coronavirus disease 2019 (COVID-19) using a nationwide COVID-19 database from South Korea. This nationwide cohort study was performed using the COVID-19 database from the Health Insurance Review and Assessment Service of Korea, and SARS-CoV-2 positivity was investigated according to BZD use. SARS-CoV-2-positive adult patients were assessed in three groups, those who needed hospitalization, those with severe symptoms requiring intensive care, and those who died. A multivariate logistic regression model was used for all the analyses. After adjusting for potential confounding factors, there was no association between BZD use and SARS-CoV-2 positivity. SARS-CoV-2-positive patients with BZD use showed an increased risk of need for hospitalization from COVID-19 compared to those without BZD use (odds ratio [OR]: 1.33, 95% confidence interval [CI] 1.07-1.65). In addition, there was a higher risk for long-term users (OR: 2.64, 95% CI 1.08-6.47). Chronic BZD use contributed to a higher risk of the need for hospitalization among COVID-19 patients, whereas BZD use did not increase the risk of SARS-CoV-2 test positivity, severe outcomes, or mortality.
. 2022 Sep 24;12(1):15947.
doi: 10.1038/s41598-022-20335-z.
A nationwide cohort study of the association of benzodiazepines with SARS-CoV-2 infection and clinical outcomes
Hye Yoon Park[SUP] #[/SUP][SUP] 1 2 [/SUP], Junhyun Kwon[SUP] #[/SUP][SUP] 3 [/SUP], Suk Kyoon An[SUP] 4 5 6 [/SUP], Eun-Cheol Park[SUP] 7 8 [/SUP]
Affiliations
- PMID: 36153398
- DOI: 10.1038/s41598-022-20335-z
Abstract
The evidence for the impact of benzodiazepine (BZD) use on infection or clinical outcomes of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is limited. We evaluated the association of BZD use with SARS-CoV-2 infection and the clinical outcomes of coronavirus disease 2019 (COVID-19) using a nationwide COVID-19 database from South Korea. This nationwide cohort study was performed using the COVID-19 database from the Health Insurance Review and Assessment Service of Korea, and SARS-CoV-2 positivity was investigated according to BZD use. SARS-CoV-2-positive adult patients were assessed in three groups, those who needed hospitalization, those with severe symptoms requiring intensive care, and those who died. A multivariate logistic regression model was used for all the analyses. After adjusting for potential confounding factors, there was no association between BZD use and SARS-CoV-2 positivity. SARS-CoV-2-positive patients with BZD use showed an increased risk of need for hospitalization from COVID-19 compared to those without BZD use (odds ratio [OR]: 1.33, 95% confidence interval [CI] 1.07-1.65). In addition, there was a higher risk for long-term users (OR: 2.64, 95% CI 1.08-6.47). Chronic BZD use contributed to a higher risk of the need for hospitalization among COVID-19 patients, whereas BZD use did not increase the risk of SARS-CoV-2 test positivity, severe outcomes, or mortality.