tetano
Editor, Senior Moderator
Sci Prog
. 2025 Jan-Mar;108(1):368504241247982.
doi: 10.1177/00368504241247982. Role of peak D-dimer in predicting mortality and venous thromboembolism in COVID-19 patients
Rachel H Lee[SUP] 1 [/SUP], Shan Wang[SUP] 1 2 [/SUP], Meredith Akerman[SUP] 2 3 [/SUP], D'Andrea Joseph[SUP] 2 4 [/SUP]
Affiliations
Covid 19 patients often present with elevated D-dimer levels. The purpose of this study is to evaluate the role of D-Dimer levels in Covid 19 patients to predict mortality and venous thromboembolism (VTE) events. This is a retrospective chart review study from 1 April 2020 to 30 June 2020, during the peak Covid pandemic. A total of 350 patients were enrolled in this study; 69 (19.7%) patients died; 12 (3.4%) had a deep venous thrombosis; and 8 (2.3%) had a pulmonary embolism outcome. Peak D-dimer levels were collected with median levels of 765 ng/ml (266, 3135). Patients with VTE outcomes had significantly higher levels of peak D-dimers than patients in the non-VTE group (4876 vs 680, p < 0.0001). Patients who died had higher peak D-dimer levels than those who survived (4690 vs 501, p < 0.0001). The optimal cutoff point in peak D-dimer in predicting VTE events was 1437, yielding a sensitivity of 84.2% and a specificity of 65.0%. The optimal cutoff point in peak D-dimer in predicting mortality was 2004, yielding a sensitivity of 71.0% and a specificity of 77.9%. This study suggests that D-dimer levels can be elevated in Covid 19 hospitalized patients and can serve as indicators for mortality and VTE events.
Keywords: COVID19; D-dimer; coagulopathy; venous thromboembolism.
. 2025 Jan-Mar;108(1):368504241247982.
doi: 10.1177/00368504241247982. Role of peak D-dimer in predicting mortality and venous thromboembolism in COVID-19 patients
Rachel H Lee[SUP] 1 [/SUP], Shan Wang[SUP] 1 2 [/SUP], Meredith Akerman[SUP] 2 3 [/SUP], D'Andrea Joseph[SUP] 2 4 [/SUP]
Affiliations
- PMID: 40012497
- DOI: 10.1177/00368504241247982
Covid 19 patients often present with elevated D-dimer levels. The purpose of this study is to evaluate the role of D-Dimer levels in Covid 19 patients to predict mortality and venous thromboembolism (VTE) events. This is a retrospective chart review study from 1 April 2020 to 30 June 2020, during the peak Covid pandemic. A total of 350 patients were enrolled in this study; 69 (19.7%) patients died; 12 (3.4%) had a deep venous thrombosis; and 8 (2.3%) had a pulmonary embolism outcome. Peak D-dimer levels were collected with median levels of 765 ng/ml (266, 3135). Patients with VTE outcomes had significantly higher levels of peak D-dimers than patients in the non-VTE group (4876 vs 680, p < 0.0001). Patients who died had higher peak D-dimer levels than those who survived (4690 vs 501, p < 0.0001). The optimal cutoff point in peak D-dimer in predicting VTE events was 1437, yielding a sensitivity of 84.2% and a specificity of 65.0%. The optimal cutoff point in peak D-dimer in predicting mortality was 2004, yielding a sensitivity of 71.0% and a specificity of 77.9%. This study suggests that D-dimer levels can be elevated in Covid 19 hospitalized patients and can serve as indicators for mortality and VTE events.
Keywords: COVID19; D-dimer; coagulopathy; venous thromboembolism.