tetano
Editor, Senior Moderator
Sci Prog
. 2025 Apr-Jun;108(2):368504251335850.
doi: 10.1177/00368504251335850. Epub 2025 Apr 17. Role of InterLeukin-6 monitoring during weaning from volume-controlled ventilation in patients with COVID-19 acute respiratory distress syndrome
Estelle Delaunay[SUP] 1 [/SUP], Nicolas Poussard[SUP] 1 [/SUP], Géraud Gourjon[SUP] 2 3 [/SUP], Antoine Frouin[SUP] 1 [/SUP], Pierre Ducq[SUP] 1 [/SUP], Lynda Di Vico[SUP] 1 [/SUP], Sébastien Moschietto[SUP] 1 [/SUP], Romaric Larcher[SUP] 1 4 [/SUP], Gaël Pradel[SUP] 1 [/SUP]
Affiliations
ObjectiveThe aim of this study was to assess the ability of plasma InterLeukin-6 (IL-6) monitoring to predict the failure to switch from volume-controlled ventilation to spontaneous ventilation (SV) in patients with COVID-19-related acute respiratory distress syndrome (ARDS).MethodsWe conducted an observational, single-center and prospective cohort study in the medico-surgical intensive care unit of Avignon Hospital Center. Participants were adult patients requiring invasive mechanical ventilation for COVID-19-related ARDS between August 2021 and August 2022, who were eligible for switching from volume-controlled ventilation to SV.ResultsAmong the 35 patients included in the study, 13 (37%) successfully switched from controlled ventilation to SV, while 22 failed (63%). In the failure group, mean plasma IL-6 levels were higher than in the successful group from hour 0 (defined as the moment of the switch to SV mode) to 48 h. However, differences between groups became significant from 24 h (362.8 vs. 33.6 pg/mL, P = 0.002). Interestingly, between-group differences in plasma C-reactive protein (CRP) levels were only significant between groups from 48 h (129.3 vs. 52.2 mg/L, P = 0.017). Finally, IL-6 and CRP had a similar ability to predict the failure to switch to SV mode: area under the receiving operative curves 0.763 [95%CI: 0.633-0.893] and 0.753 [95%CI: 0.595-0.911], respectively (P = 0.87).ConclusionsIL-6 and CRP are inflammatory biomarkers predictive of failure to switch to SV mode in COVID-19 ARDS patients. Our results showed that IL-6 can detect failure earlier than CRP. However, larger multicenter studies are needed to confirm our results, particularly in other ARDS models.
Keywords: ARDS; COVID-19; interLeukin-6; spontaneous ventilation mode; ventilatory weaning.
. 2025 Apr-Jun;108(2):368504251335850.
doi: 10.1177/00368504251335850. Epub 2025 Apr 17. Role of InterLeukin-6 monitoring during weaning from volume-controlled ventilation in patients with COVID-19 acute respiratory distress syndrome
Estelle Delaunay[SUP] 1 [/SUP], Nicolas Poussard[SUP] 1 [/SUP], Géraud Gourjon[SUP] 2 3 [/SUP], Antoine Frouin[SUP] 1 [/SUP], Pierre Ducq[SUP] 1 [/SUP], Lynda Di Vico[SUP] 1 [/SUP], Sébastien Moschietto[SUP] 1 [/SUP], Romaric Larcher[SUP] 1 4 [/SUP], Gaël Pradel[SUP] 1 [/SUP]
Affiliations
- PMID: 40241622
- DOI: 10.1177/00368504251335850
ObjectiveThe aim of this study was to assess the ability of plasma InterLeukin-6 (IL-6) monitoring to predict the failure to switch from volume-controlled ventilation to spontaneous ventilation (SV) in patients with COVID-19-related acute respiratory distress syndrome (ARDS).MethodsWe conducted an observational, single-center and prospective cohort study in the medico-surgical intensive care unit of Avignon Hospital Center. Participants were adult patients requiring invasive mechanical ventilation for COVID-19-related ARDS between August 2021 and August 2022, who were eligible for switching from volume-controlled ventilation to SV.ResultsAmong the 35 patients included in the study, 13 (37%) successfully switched from controlled ventilation to SV, while 22 failed (63%). In the failure group, mean plasma IL-6 levels were higher than in the successful group from hour 0 (defined as the moment of the switch to SV mode) to 48 h. However, differences between groups became significant from 24 h (362.8 vs. 33.6 pg/mL, P = 0.002). Interestingly, between-group differences in plasma C-reactive protein (CRP) levels were only significant between groups from 48 h (129.3 vs. 52.2 mg/L, P = 0.017). Finally, IL-6 and CRP had a similar ability to predict the failure to switch to SV mode: area under the receiving operative curves 0.763 [95%CI: 0.633-0.893] and 0.753 [95%CI: 0.595-0.911], respectively (P = 0.87).ConclusionsIL-6 and CRP are inflammatory biomarkers predictive of failure to switch to SV mode in COVID-19 ARDS patients. Our results showed that IL-6 can detect failure earlier than CRP. However, larger multicenter studies are needed to confirm our results, particularly in other ARDS models.
Keywords: ARDS; COVID-19; interLeukin-6; spontaneous ventilation mode; ventilatory weaning.