tetano
Editor, Senior Moderator
Sci Prog
. Apr-Jun 2022;105(2):368504221105172.
doi: 10.1177/00368504221105172.
Revisiting the potential role of BCG and MMR vaccines in COVID-19
Zeina Bayram[SUP] 1 [/SUP], Umayya Musharrafieh[SUP] 2 3 [/SUP], Abdul Rahman Bizri[SUP] 2 [/SUP]
Affiliations
Abstract
Despite the development and deployment of effective COVID-19 vaccines, many regions remain poorly covered. Seeking alternative tools for achieving immunity against COVID-19 remains to be of high importance. "Trained immunity" is the nonspecific immune response usually established through administering live attenuated vaccines and is a potential preventive tool against unrelated infections. Evidence regarding a possible protective role for certain live attenuated vaccines against COVID-19 has emerged mainly for those administered as part of childhood vaccination protocols. This review summarizes the relevant literature about the potential impact of Bacille Calmette-Guérin (BCG) and measles, mumps and rubella (MMR) vaccines on COVID-19. Existing available data suggest a potential role for BCG and MMR in reducing COVID-19 casualties and burden. However, more investigation and comparative studies are required for a better understanding of their impact on COVID-19 outcomes.
Keywords: BCG; COVID-19; MMR; coronavirus; immunity.
. Apr-Jun 2022;105(2):368504221105172.
doi: 10.1177/00368504221105172.
Revisiting the potential role of BCG and MMR vaccines in COVID-19
Zeina Bayram[SUP] 1 [/SUP], Umayya Musharrafieh[SUP] 2 3 [/SUP], Abdul Rahman Bizri[SUP] 2 [/SUP]
Affiliations
- PMID: 35848578
- DOI: 10.1177/00368504221105172
Abstract
Despite the development and deployment of effective COVID-19 vaccines, many regions remain poorly covered. Seeking alternative tools for achieving immunity against COVID-19 remains to be of high importance. "Trained immunity" is the nonspecific immune response usually established through administering live attenuated vaccines and is a potential preventive tool against unrelated infections. Evidence regarding a possible protective role for certain live attenuated vaccines against COVID-19 has emerged mainly for those administered as part of childhood vaccination protocols. This review summarizes the relevant literature about the potential impact of Bacille Calmette-Guérin (BCG) and measles, mumps and rubella (MMR) vaccines on COVID-19. Existing available data suggest a potential role for BCG and MMR in reducing COVID-19 casualties and burden. However, more investigation and comparative studies are required for a better understanding of their impact on COVID-19 outcomes.
Keywords: BCG; COVID-19; MMR; coronavirus; immunity.