tetano
Editor, Senior Moderator
Sci Adv
. 2024 Jun 14;10(24):eadi1379.
doi: 10.1126/sciadv.adi1379. Epub 2024 Jun 12. COVID-19 point-of-care tests can identify low-antibody individuals: In-depth immunoanalysis of boosting benefits in a healthy cohort
Michael Mallory[SUP] 1 2 [/SUP], Jennifer E Munt[SUP] 1 2 [/SUP], Tara M Narowski[SUP] 1 [/SUP], Izabella Castillo[SUP] 1 [/SUP], Edwing Cuadra[SUP] 1 [/SUP], Nora Pisanic[SUP] 3 [/SUP], Paul Fields[SUP] 4 [/SUP], John M Powers[SUP] 1 2 [/SUP], Alexandria Dickson[SUP] 5 [/SUP], Rohan Harris[SUP] 6 [/SUP], Richard Wargowsky[SUP] 7 [/SUP], Seamus Moran[SUP] 6 [/SUP], Ahmed Allabban[SUP] 6 [/SUP], Kristin Raphel[SUP] 6 [/SUP], Timothy A McCaffrey[SUP] 7 [/SUP], James D Brien[SUP] 5 [/SUP], Christopher D Heaney[SUP] 3 8 [/SUP], John E Lafleur[SUP] 6 [/SUP], Ralph S Baric[SUP] 1 2 [/SUP], Lakshmanane Premkumar[SUP] 1 [/SUP]
Affiliations
The recommended COVID-19 booster vaccine uptake is low. At-home lateral flow assay (LFA) antigen tests are widely accepted for detecting infection during the pandemic. Here, we present the feasibility and potential benefits of using LFA-based antibody tests as a means for individuals to detect inadequate immunity and make informed decisions about COVID-19 booster immunization. In a health care provider cohort, we investigated the changes in the breadth and depth of humoral and T cell immune responses following mRNA vaccination and boosting in LFA-positive and LFA-negative antibody groups. We show that negative LFA antibody tests closely reflect the lack of functional humoral immunity observed in a battery of sophisticated immune assays, while positive results do not necessarily reflect adequate immunity. After booster vaccination, both groups gain depth and breadth of systemic antibodies against evolving SARS-CoV-2 and related viruses. Our findings show that LFA-based antibody tests can alert individuals about inadequate immunity against COVID-19, thereby increasing booster shots and promoting herd immunity.
. 2024 Jun 14;10(24):eadi1379.
doi: 10.1126/sciadv.adi1379. Epub 2024 Jun 12. COVID-19 point-of-care tests can identify low-antibody individuals: In-depth immunoanalysis of boosting benefits in a healthy cohort
Michael Mallory[SUP] 1 2 [/SUP], Jennifer E Munt[SUP] 1 2 [/SUP], Tara M Narowski[SUP] 1 [/SUP], Izabella Castillo[SUP] 1 [/SUP], Edwing Cuadra[SUP] 1 [/SUP], Nora Pisanic[SUP] 3 [/SUP], Paul Fields[SUP] 4 [/SUP], John M Powers[SUP] 1 2 [/SUP], Alexandria Dickson[SUP] 5 [/SUP], Rohan Harris[SUP] 6 [/SUP], Richard Wargowsky[SUP] 7 [/SUP], Seamus Moran[SUP] 6 [/SUP], Ahmed Allabban[SUP] 6 [/SUP], Kristin Raphel[SUP] 6 [/SUP], Timothy A McCaffrey[SUP] 7 [/SUP], James D Brien[SUP] 5 [/SUP], Christopher D Heaney[SUP] 3 8 [/SUP], John E Lafleur[SUP] 6 [/SUP], Ralph S Baric[SUP] 1 2 [/SUP], Lakshmanane Premkumar[SUP] 1 [/SUP]
Affiliations
- PMID: 38865463
- PMCID: PMC11168476
- DOI: 10.1126/sciadv.adi1379
The recommended COVID-19 booster vaccine uptake is low. At-home lateral flow assay (LFA) antigen tests are widely accepted for detecting infection during the pandemic. Here, we present the feasibility and potential benefits of using LFA-based antibody tests as a means for individuals to detect inadequate immunity and make informed decisions about COVID-19 booster immunization. In a health care provider cohort, we investigated the changes in the breadth and depth of humoral and T cell immune responses following mRNA vaccination and boosting in LFA-positive and LFA-negative antibody groups. We show that negative LFA antibody tests closely reflect the lack of functional humoral immunity observed in a battery of sophisticated immune assays, while positive results do not necessarily reflect adequate immunity. After booster vaccination, both groups gain depth and breadth of systemic antibodies against evolving SARS-CoV-2 and related viruses. Our findings show that LFA-based antibody tests can alert individuals about inadequate immunity against COVID-19, thereby increasing booster shots and promoting herd immunity.