tetano
Editor, Senior Moderator
Clin Infect Dis. 2014 May 14. pii: ciu340. [Epub ahead of print]
School-located influenza vaccination decreases laboratory-confirmed influenza and improves school attendance.
Pannaraj PS1, Wang H2, Rivas H3, Wiryawan H2, Smit M2, Green N3, Aldrovandi GM1, El Amin AN4, Mascola L5.
Author information
Abstract
BACKGROUND:
School-located influenza vaccination (SLV) programs can efficiently immunize large numbers of school-aged children. We evaluated the impact of SLV on laboratory-confirmed influenza and absenteeism.
METHODS:
Active surveillance for influenza-like illness (ILI) was conducted on 4455 children in four SLV intervention and four control elementary schools (grades K-6) matched for size and sociodemographic characteristics during the 2010-2011 influenza season in Los Angeles County. Polymerase chain reaction (PCR) for respiratory viruses was performed on nose and throat swabs collected from febrile children with ILI at presentation to the school nurse or during absenteeism.
RESULTS:
In SLV schools, 26.9 to 46.6% of enrolled students received at least one dose of either inactivated or live attenuated influenza vaccine compared with 0.8 to 4.3% in control schools. PCR was performed on 1021 specimens obtained from 898 children. Specimens were positive for influenza in 217 (21.3%) including 2009 H1N1 (30.9%), H3 (9.2%) and B (59.9%). Children attending SLV schools, regardless of vaccination status, were 30.8% (95% CI: 10.1-46.8%) less likely to acquire influenza compared with control schools. Unvaccinated children were indirectly protected in the school with 46.6% vaccination coverage compared with control schools (influenza rate: 27.1 vs. 60.0 per 1000 children, p=0.023). Unvaccinated children missed more school days than vaccinated children (4.3 vs. 2.8 days per 100 school days, p<0.001).
CONCLUSIONS:
Vaccination of at least a quarter of the school population resulted in decreased influenza rates and improved school attendance. Herd immunity for unvaccinated children may occur in schools with vaccination coverage approaching 50%.
? The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.
PMID:
24829215
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24829215
School-located influenza vaccination decreases laboratory-confirmed influenza and improves school attendance.
Pannaraj PS1, Wang H2, Rivas H3, Wiryawan H2, Smit M2, Green N3, Aldrovandi GM1, El Amin AN4, Mascola L5.
Author information
Abstract
BACKGROUND:
School-located influenza vaccination (SLV) programs can efficiently immunize large numbers of school-aged children. We evaluated the impact of SLV on laboratory-confirmed influenza and absenteeism.
METHODS:
Active surveillance for influenza-like illness (ILI) was conducted on 4455 children in four SLV intervention and four control elementary schools (grades K-6) matched for size and sociodemographic characteristics during the 2010-2011 influenza season in Los Angeles County. Polymerase chain reaction (PCR) for respiratory viruses was performed on nose and throat swabs collected from febrile children with ILI at presentation to the school nurse or during absenteeism.
RESULTS:
In SLV schools, 26.9 to 46.6% of enrolled students received at least one dose of either inactivated or live attenuated influenza vaccine compared with 0.8 to 4.3% in control schools. PCR was performed on 1021 specimens obtained from 898 children. Specimens were positive for influenza in 217 (21.3%) including 2009 H1N1 (30.9%), H3 (9.2%) and B (59.9%). Children attending SLV schools, regardless of vaccination status, were 30.8% (95% CI: 10.1-46.8%) less likely to acquire influenza compared with control schools. Unvaccinated children were indirectly protected in the school with 46.6% vaccination coverage compared with control schools (influenza rate: 27.1 vs. 60.0 per 1000 children, p=0.023). Unvaccinated children missed more school days than vaccinated children (4.3 vs. 2.8 days per 100 school days, p<0.001).
CONCLUSIONS:
Vaccination of at least a quarter of the school population resulted in decreased influenza rates and improved school attendance. Herd immunity for unvaccinated children may occur in schools with vaccination coverage approaching 50%.
? The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.
PMID:
24829215
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24829215