tetano
Editor, Senior Moderator
Scand J Trauma Resusc Emerg Med
. 2025 May 1;33(1):75.
doi: 10.1186/s13049-025-01395-2. Impact of COVID-19 on mortality in out-of-hospital cardiac arrest patients with return of spontaneous circulation: a retrospective cohort study
Nai-Chen Shih[SUP] #[/SUP][SUP] 1 2 [/SUP], Han-Wei Yeh[SUP] #[/SUP][SUP] 3 4 5 [/SUP], Shun-Fa Yang[SUP] 1 6 [/SUP], Yu-Hsun Wang[SUP] 1 6 [/SUP], Chung-Hsien Chaou[SUP] 7 8 9 [/SUP], Chao-Bin Yeh[SUP] 10 11 12 [/SUP]
Affiliations
Background: This study aims to compare the mortality rates of OHCA patients with and without COVID-19 infection across different follow-up periods and explores the factors may play a significant role in determining OHCA outcomes.
Methods: This study utilized data from the US Collaborative Network in TriNetX. A total of 25,271 hospitalized OHCA patients were recruited from records spanning from January 1, 2020, to December 31, 2023. Study population divided into two groups, COVID-19 positive and COVID-19 negative groups. The mortality risk of the two groups was observed based on different follow-up periods. Subgroup analyses on sex, age, antivirals use, COVID-19 virus variant epidemic period were also conducted.
Results: Our study included 2,776 patients in each group (COVID vs. non-COVID). The primary outcome was mortality at 14-day and 90-day follow-ups. COVID-19 patients had a lower 14-day mortality (HR 0.82, 95% CI: 0.76-0.88) but higher 90-day mortality (HR 1.16, 95% CI: 1.09-1.24) compared to non-COVID-19 patients. Secondary outcomes included higher mortality in COVID-19 patients under 65, and this trend persisted in those aged 65 and over. Male COVID-19 patients had elevated mortality risk. The Alpha and Delta variant period showed a higher mortality rate for COVID-19 patients than non-COVID-19 patients.
Conclusion: COVID-19 was associated with a higher risk of mortality in OHCA patients.
Keywords: COVID-19 infection; Mortality; Out-of-hospital cardiac arrest; Retrospective cohort study.
. 2025 May 1;33(1):75.
doi: 10.1186/s13049-025-01395-2. Impact of COVID-19 on mortality in out-of-hospital cardiac arrest patients with return of spontaneous circulation: a retrospective cohort study
Nai-Chen Shih[SUP] #[/SUP][SUP] 1 2 [/SUP], Han-Wei Yeh[SUP] #[/SUP][SUP] 3 4 5 [/SUP], Shun-Fa Yang[SUP] 1 6 [/SUP], Yu-Hsun Wang[SUP] 1 6 [/SUP], Chung-Hsien Chaou[SUP] 7 8 9 [/SUP], Chao-Bin Yeh[SUP] 10 11 12 [/SUP]
Affiliations
- PMID: 40312395
- PMCID: PMC12044919
- DOI: 10.1186/s13049-025-01395-2
Background: This study aims to compare the mortality rates of OHCA patients with and without COVID-19 infection across different follow-up periods and explores the factors may play a significant role in determining OHCA outcomes.
Methods: This study utilized data from the US Collaborative Network in TriNetX. A total of 25,271 hospitalized OHCA patients were recruited from records spanning from January 1, 2020, to December 31, 2023. Study population divided into two groups, COVID-19 positive and COVID-19 negative groups. The mortality risk of the two groups was observed based on different follow-up periods. Subgroup analyses on sex, age, antivirals use, COVID-19 virus variant epidemic period were also conducted.
Results: Our study included 2,776 patients in each group (COVID vs. non-COVID). The primary outcome was mortality at 14-day and 90-day follow-ups. COVID-19 patients had a lower 14-day mortality (HR 0.82, 95% CI: 0.76-0.88) but higher 90-day mortality (HR 1.16, 95% CI: 1.09-1.24) compared to non-COVID-19 patients. Secondary outcomes included higher mortality in COVID-19 patients under 65, and this trend persisted in those aged 65 and over. Male COVID-19 patients had elevated mortality risk. The Alpha and Delta variant period showed a higher mortality rate for COVID-19 patients than non-COVID-19 patients.
Conclusion: COVID-19 was associated with a higher risk of mortality in OHCA patients.
Keywords: COVID-19 infection; Mortality; Out-of-hospital cardiac arrest; Retrospective cohort study.