tetano
Editor, Senior Moderator
Scand J Immunol
. 2020 Jul 22;e12947.
doi: 10.1111/sji.12947. Online ahead of print.
The effect of BCG vaccine in the era of COVID-19 pandemic
Ahmed M Abbas[SUP] 1 2 [/SUP], Asmaa AbouBakr[SUP] 2 3 [/SUP], Nermeen Bahaa[SUP] 2 4 [/SUP], Sherry Michael[SUP] 2 3 [/SUP], Marco Ghobrial[SUP] 5 [/SUP], Mai E AbuElmagd[SUP] 2 3 [/SUP], Omar A Ahmed[SUP] 6 [/SUP], Radwa A AbdelWahab[SUP] 7 [/SUP], Asmaa S Shaltout[SUP] 7 [/SUP]
Affiliations
Abstract
Coronavirus Disease-2019 (COVID-19) has become a worldwide emergency and announced as a pandemic recently with variable incidence and mortality in different geographical areas. The relationship between COVID-19 and Bacille Calmette Gu?rin (BCG) vaccine is still under investigation, and we aim to clarify this matter. BCG is a live attenuated tuberculosis vaccine. BCG vaccination of adult humans induces strained circulating monocytes having an increase in their capacity to produce proinflammatory cytokines. This effect translates to non-specific protection against unrelated pathogens, an example of which is S. aureus and C. Albicans. Also, vaccination of BCG of healthy volunteers showed an increase in the capacity of natural killer (NK) cells to secrete proinflammatory cytokines, such as IL-1β and IL-6 after stimulation with M. tuberculosis or unrelated pathogens (S. aureus, C. Albicans).
. 2020 Jul 22;e12947.
doi: 10.1111/sji.12947. Online ahead of print.
The effect of BCG vaccine in the era of COVID-19 pandemic
Ahmed M Abbas[SUP] 1 2 [/SUP], Asmaa AbouBakr[SUP] 2 3 [/SUP], Nermeen Bahaa[SUP] 2 4 [/SUP], Sherry Michael[SUP] 2 3 [/SUP], Marco Ghobrial[SUP] 5 [/SUP], Mai E AbuElmagd[SUP] 2 3 [/SUP], Omar A Ahmed[SUP] 6 [/SUP], Radwa A AbdelWahab[SUP] 7 [/SUP], Asmaa S Shaltout[SUP] 7 [/SUP]
Affiliations
- PMID: 32698247
- DOI: 10.1111/sji.12947
Abstract
Coronavirus Disease-2019 (COVID-19) has become a worldwide emergency and announced as a pandemic recently with variable incidence and mortality in different geographical areas. The relationship between COVID-19 and Bacille Calmette Gu?rin (BCG) vaccine is still under investigation, and we aim to clarify this matter. BCG is a live attenuated tuberculosis vaccine. BCG vaccination of adult humans induces strained circulating monocytes having an increase in their capacity to produce proinflammatory cytokines. This effect translates to non-specific protection against unrelated pathogens, an example of which is S. aureus and C. Albicans. Also, vaccination of BCG of healthy volunteers showed an increase in the capacity of natural killer (NK) cells to secrete proinflammatory cytokines, such as IL-1β and IL-6 after stimulation with M. tuberculosis or unrelated pathogens (S. aureus, C. Albicans).