tetano
Editor, Senior Moderator
Scand J Immunol
. 2020 May 23;e12895.
doi: 10.1111/sji.12895. Online ahead of print.
SARS-CoV-2 Infection-Induced Immune Responses: Friends or Foes?
Keying Li[SUP] 1 [/SUP], Zhenhua Hao[SUP] 2 [/SUP], Xiaohui Zhao[SUP] 2 [/SUP], Jiying Du[SUP] 1 [/SUP], Yanlin Zhou[SUP] 2 [/SUP]
Affiliations
Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an emerging coronavirus that belongs to the β genus, causing the outbreak of coronavirus disease 19 (COVID-19). SARS-CoV-2 infection can stimulate a pronounced immune response in the host, which embodies in the decrease of lymphocytes and aberrant increase of cytokines in COVID-19 patients. SARS-CoV-2 RNA and proteins interact with various pattern recognition receptors that switch on antiviral immune responses to regulate viral replication and spreading within the host in vivo. However, overactive and impaired immune responses also cause immune damage and subsequent tissue inflammation. This article focuses on the dual roles of immune system during SARS-CoV-2 infection, providing a theoretical basic for identifying therapeutic targets in a situation with an unfavorable immune reaction.
Keywords: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); coronavirus disease 19 (COVID-19); cytokine storm; inflammation.
. 2020 May 23;e12895.
doi: 10.1111/sji.12895. Online ahead of print.
SARS-CoV-2 Infection-Induced Immune Responses: Friends or Foes?
Keying Li[SUP] 1 [/SUP], Zhenhua Hao[SUP] 2 [/SUP], Xiaohui Zhao[SUP] 2 [/SUP], Jiying Du[SUP] 1 [/SUP], Yanlin Zhou[SUP] 2 [/SUP]
Affiliations
- PMID: 32445403
- DOI: 10.1111/sji.12895
Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an emerging coronavirus that belongs to the β genus, causing the outbreak of coronavirus disease 19 (COVID-19). SARS-CoV-2 infection can stimulate a pronounced immune response in the host, which embodies in the decrease of lymphocytes and aberrant increase of cytokines in COVID-19 patients. SARS-CoV-2 RNA and proteins interact with various pattern recognition receptors that switch on antiviral immune responses to regulate viral replication and spreading within the host in vivo. However, overactive and impaired immune responses also cause immune damage and subsequent tissue inflammation. This article focuses on the dual roles of immune system during SARS-CoV-2 infection, providing a theoretical basic for identifying therapeutic targets in a situation with an unfavorable immune reaction.
Keywords: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); coronavirus disease 19 (COVID-19); cytokine storm; inflammation.