tetano
Editor, Senior Moderator
Scand J Immunol
. 2020 Nov 15;e12999.
doi: 10.1111/sji.12999. Online ahead of print.
Gastrointestinal and Renal Complications in SARS-CoV-2-Infected Patients: Role of Immune System
Fatemeh Maghool[SUP] 1 [/SUP], Ali Valiani[SUP] 2 [/SUP], Tahereh Safari[SUP] 3 [/SUP], Mohammad Hassan Emami[SUP] 1 [/SUP], Samane Mohammadzadeh[SUP] 1 [/SUP]
Affiliations
Abstract
The recent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease has been accompanied with various gastrointestinal (GI) and renal manifestations in significant portion of infected patients. Beside studies on the respiratory complications of coronavirus infection, understanding the essential immunological processes underlying the different clinical manifestations of virus infection is crucial for the identification and development of effective therapies. In addition to the respiratory tract, the digestive and urinary systems are the major sources of virus transmission. Thus, knowledge about the invasion mechanisms of SARS-CoV-2 in these systems and the immune system responses are important for implementing the infection prevention strategies. This article presents an overview of the gut and renal complications in SARS-CoV-2 infection. We focus on how SARS-CoV-2 interacts with the immune system and the consequent contribution of immune system, gut, and renal dysfunctions in the development of disease.
Keywords: Acute kidney injury; Anti-viral immunity; COVID-19; Gastrointestinal; Kidney; SARS-CoV-2.
. 2020 Nov 15;e12999.
doi: 10.1111/sji.12999. Online ahead of print.
Gastrointestinal and Renal Complications in SARS-CoV-2-Infected Patients: Role of Immune System
Fatemeh Maghool[SUP] 1 [/SUP], Ali Valiani[SUP] 2 [/SUP], Tahereh Safari[SUP] 3 [/SUP], Mohammad Hassan Emami[SUP] 1 [/SUP], Samane Mohammadzadeh[SUP] 1 [/SUP]
Affiliations
- PMID: 33190306
- DOI: 10.1111/sji.12999
Abstract
The recent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease has been accompanied with various gastrointestinal (GI) and renal manifestations in significant portion of infected patients. Beside studies on the respiratory complications of coronavirus infection, understanding the essential immunological processes underlying the different clinical manifestations of virus infection is crucial for the identification and development of effective therapies. In addition to the respiratory tract, the digestive and urinary systems are the major sources of virus transmission. Thus, knowledge about the invasion mechanisms of SARS-CoV-2 in these systems and the immune system responses are important for implementing the infection prevention strategies. This article presents an overview of the gut and renal complications in SARS-CoV-2 infection. We focus on how SARS-CoV-2 interacts with the immune system and the consequent contribution of immune system, gut, and renal dysfunctions in the development of disease.
Keywords: Acute kidney injury; Anti-viral immunity; COVID-19; Gastrointestinal; Kidney; SARS-CoV-2.