tetano
Editor, Senior Moderator
Scand J Immunol
. 2020 Jul 22;e12944.
doi: 10.1111/sji.12944. Online ahead of print.
?Are Superantigens the Cause of Cytokine Storm and viral sepsis in Severe COVID-19? Observations and hypothesis
Valeria Scaglioni[SUP] 1 [/SUP], Enrique R Soriano[SUP] 1 [/SUP]
Affiliations
Abstract
Right now the world is going through an unprecedented pandemic caused by a novel coronavirus. Recent papers pointed out the fatal outcome in most of the severe cases, in which a cytokine storm has been proven to be the cause of a systemic shock, acute respiratory syndrome, multiorgan failure and consequently death. Several explanations have been proposed trying to explain the pathophysiology of the cytokine storm, but viral proteins with a possible superantigen activity as a cause of immune dysregulation has not been addressed. If this hypothesis is proven, a different treatment approach might change the outcome in severe cases.
Keywords: COVID-19; cytokine storm; shock; superantigen.
. 2020 Jul 22;e12944.
doi: 10.1111/sji.12944. Online ahead of print.
?Are Superantigens the Cause of Cytokine Storm and viral sepsis in Severe COVID-19? Observations and hypothesis
Valeria Scaglioni[SUP] 1 [/SUP], Enrique R Soriano[SUP] 1 [/SUP]
Affiliations
- PMID: 32697367
- DOI: 10.1111/sji.12944
Abstract
Right now the world is going through an unprecedented pandemic caused by a novel coronavirus. Recent papers pointed out the fatal outcome in most of the severe cases, in which a cytokine storm has been proven to be the cause of a systemic shock, acute respiratory syndrome, multiorgan failure and consequently death. Several explanations have been proposed trying to explain the pathophysiology of the cytokine storm, but viral proteins with a possible superantigen activity as a cause of immune dysregulation has not been addressed. If this hypothesis is proven, a different treatment approach might change the outcome in severe cases.
Keywords: COVID-19; cytokine storm; shock; superantigen.