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Saudi Arabia: Al-Khurma virus back in Jeddah

Shiloh

Editor, Senior Moderator
Source: http://www.saudigazette.com.sa/index.cfm?method=home.regcon&contentID=2010010759377

Al-Khumra virus back in Jeddah
By Mohammed Hadhadh and Hussein Hazazi
Rabeah: Four cases treated immediately

JEDDAH ? The confirmation that four persons admitted to hospital Tuesday have contracted the little-known ?Al-Khumra? fever ? the first appearance of the potentially fatal illness in Jeddah for nearly 10 years ? has raised the concerns of the minister of health and experts in contagious diseases.
The four cases, detected in residents of the north of the city Tuesday, were described by Health Minister Abdullah Al-Rabeah Wednesday as ?only individual cases which were immediately treated?.
The four persons were admitted to hospital the same day as laboratory tests confirmed the diagnosis, and the Mayor?s Office ordered that the zone around the houses where they lived be sprayed with pesticide.
Dr. Tariq Madani, a contagious disease specialist from King Abdulaziz University, said that studies on the obscure virus are few, and that it still has no vaccination or cure. ?The virus is more dangerous than Rift Valley Fever, and the authorities should move to combat it as quickly as possible before it gains strength,? Dr. Madani said. ?This requires collaboration with university researchers from the ministries of Health, Agriculture and Municipal Affairs.?
Dr. Madani said the virus manifested itself in high fever, inflammation of the liver and brain, and bleeding from the gums, nose, stomach, anus, womb, urinary tract or skin.
?It is fatal for one in four,? Madani said.

Animal contact
?The way it passed on is still not entirely clear, but initial studies show that it can be passed on to humans from animals through direct contact, or through various types of mosquito as happens with Rift Valley Fever,? Madani said. ?The first information on it when it appeared in Makkah around ten years ago showed that all the persons infected had had contact with cattle or lived close to one of the four main abattoirs in the city.
None of the infected had been bitten by rodents commonly associated with viruses of a similar nature.
According to the head of the Health and Environment Committee at Jeddah?s Municipal Council, Dr. Hussein Al-Barr, a Chair has been set up at King Abdulaziz University in the name of Sheikh Mohammed Hussein Al-Amoudi to ?study the virus and find ways to counter it?.
But detailed knowledge remains scarce.
Dr. Madani said there had been no real scientific investigations into the nature of virus anywhere in the world.
?That?s because it has not been isolated by scientists anywhere else in the world, and all that?s been done are some gene-mapping studies and comparisons with viruses of the same type,? Madani said.
The virus reportedly acquired its name in 1994 when four cases were discovered in the Al-Khumra District of Jeddah after it was initially thought that they had been infected with Dengue fever.
No further cases of the Al-Khumra virus were recorded in Jeddah until the year 2000 when 20 persons were found to be infected. Again, all were residents of the Al-Khumra district in the south of Jeddah.
In March of 2009, however, authorities in Najran announced four cases, and the Ministry of Health said the virus had been present ? without disclosing the number of cases - in the region for several years, identifying ?infected cattle? as the source.
The ministry at the time described the symptoms of Al-Khumra as a ?sudden fever leading to nervous disorder?, but reassured the public that there was ?no cause for concern? as the virus had ?only affected a small number of people and does not spread rapidly?.
The father of one girl in Najran who caught the virus said she spent ten days in intensive care before being discharged, and locals said that authorities had for a year been trying to play down the threat. ? Okaz/SG
 
Re: Saudi Arabia: Al-Khumra virus back in Jeddah

Re: Saudi Arabia: Al-Khumra virus back in Jeddah

There seems to be some discrepancy as to the correct spelling of this agent. The ProMED post below refers to it as "Alkhurma", whereas the thread title is currently "Al-Khumra".

http://www.promedmail.org/pls/otn/f..._BACK_PAGE,F2400_P1001_PUB_MAIL_ID:1000,80783

Archive Number 20100106.0056
Published Date 06-JAN-2010
Subject PRO/AH/EDR> Alkhurma virus - Saudi Arabia: (MK)


ALKHURMA VIRUS - SAUDI ARABIA: (MAKKAH)
***************************************
A ProMED-mail post
<http://www.promedmail.org>
ProMED-mail is a program of the
International Society for Infectious Diseases
<http://www.isid.org>


Date: Wed 6 Jan 2010
Source: OKAZ [in Arabic, machine trans., edited]
<http://www.okaz.com.sa/new/Issues/20100106/Con20100106325138.htm>


Laboratory tests in Jeddah identified 4 cases of Alkhurma hemorrhagic
fever [AHFV] disease, which re-emerged following the tragic outbreak
in Jeddah [Makkah province]. These are the 1st cases after an absence
of about 10 years. The sources said AHFV was detected yesterday [5
Jan 2010] in 4 people living in neighborhoods north of the city who
were treated immediately in a health center. The Health Secretariat
of Jeddah conducted spraying of pesticides in the vicinity of the
houses of the 4.

In turn, the chairman of the Committee on Health and the Environment
of the Municipal Council of Jeddah, Dr. Hussein, was informed of the
need to intensify spraying, in order to prevent the spread of [the virus].

AHFV enters the human body and leads to internal bleeding. The
mortality rate of the disease is up to 25 percent of the total cases.
AHFV is transmitted by mosquitoes from one person to another [this
has not been demonstrated. See references below. - Mod.TY].

A municipal council member said that the disease was discovered for
the 1st time in Jeddah in 1994, with 4 cases. Cases of the disease,
which has gained the name AHFV, were [originally] believed to be
dengue fever infections. [The Madani 2006 reference below states that
the virus was first isolated in 1995, and that there were 6 cases. - Mod.TY]

[A team of researchers] at the University of King Abdul-Aziz, on
behalf of Sheikh Mohammed Hussein Al Amoudi, is working to diagnose
the virus and to highlight its characteristics and how to eliminate it.

It is noteworthy that the virus disappeared after the mid-1990s and
returned to the area again, according to the adviser to the minister
of health for infectious diseases, Dr Tarek Madani, in the beginning
of the new millennium.

In 2000, health authorities discovered 20 cases of the disease, and
noted that all reported cases of AHFV had ocurred south of Jeddah.

--
Communicated by:
ProMED-mail
<promed@promedmail.org>

[Alkhurma virus is a flavivirus related to Kysanur Forest disease
virus. From 8 Feb 2001 to 9 Feb 2003, a total of 37 cases of acute
viral hemorrhagic fever were identified in Makkah, Saudi Arabia, and
20 of them were laboratory confirmed. Acute febrile flu-like illness
with hepatitis (100 percent), hemorrhagic manifestations (55
percent), and encephalitis (20 percent) were the main clinical
features. The case fatality rate was 25 percent. The original report
indicated that the virus seemed to be transmitted from sheep or goats
to humans by mosquito bites or direct contact with these animals. The
report above also indicated that the virus is mosquito transmitted,
although a 2007 report implicated soft ticks.


References
----------
1. Madani TA: Alkhumra [sic] virus infection, a new viral hemorrhagic
fever in Saudi Arabia. J Infect. 2005 Aug; 51(2): 91-7; abstract available at
<http://www.ncbi.nlm.nih.gov/pubmed/16038757>.
2. Charrel RN, Zaki AM, Fagbo S, de Lamballerie X: Alkhurma
hemorrhagic fever virus is an emerging tick-borne flavivirus. J
Infect. 2006 Jun; 52(6): 463-4.
3. Charrel RN, Fagbo S, Moureau G, Alqahtani MH, et al: Alkhurma
hemorrhagic fever virus in _Ornithodoros savignyi_ ticks. Emerg
Infect Dis. 2007 Jan; 13(1): 153-5; available at
<http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2725816/>.

Jeddah on the coast of the Red Sea, can be located on the map at
<http://www.lib.utexas.edu/maps/middle_east_and_asia/saudi_arabia_pol_2003.pdf>.
A HealthMap/ProMED-mail interactive map of Saudi Arabia can be
accessed at <http://healthmap.org/r/011Z>. - Mod.TY]

[see also:
2004
----
Alkhurma virus, human death - Saudi Arabia (02) 20040309.0666
Alkhurma virus, human death - Saudi Arabia 20040302.0631
2003
----
Dengue/DHF update 2003 (09) 20030303.0532
Tick-borne flavivirus - Saudi Arabia 20020509.4144
1997
----
Encephalitis, tickborne - Saudi Arabia 19970907.1921
Encephalitis, tickborne - Saudi Arabia (02) 19970907.1933
Encephalitis, tickborne - Saudi Arabia (03) 19970914.1959
Encephalitis, tickborne - Saudi Arabia (04) 19970914.1963
Encephalitis, Tickborne - Saudi Arabia (05) 19970916.1967
Encephalitis, tickborne - Saudi Arabia (06) 19970917.1973
...................................ty/mj/dk
 
Re: Saudi Arabia: Al-Khumra virus back in Jeddah

Re: Saudi Arabia: Al-Khumra virus back in Jeddah

Source: http://www.arabnews.com/?page=1&sec...2&m=1&y=2010&pix=kingdom.jpg&category=Kingdom

Tuesday 12 January 2010 (26 Muharram 1431)

Jeddah health office warns of Al-Khurma fever
Muhammad Humaidan | Arab News


JEDDAH: The Directorate of Health Affairs in Jeddah has warned the public over Al-Khurma fever, particularly people who deal with cattle or meat. Four cases of the virus have been confirmed in Jeddah over the last three weeks. One of them is a butcher.

"The major symptoms of the disease include fever accompanied by body pains and headaches for three to eight days, rashes or nose bleeds and blood in the urine or stool," Director of Health Affairs in Jeddah Sami Badawood said on Monday.

The virus may affect the liver and lead to symptoms of jaundice in some cases. It is also known to attack the nervous system, resulting in comas, spasms or stiffness in the neck, Badawood added.

The primary difference between Al-Khurma fever and dengue fever is that the former is transmitted through ticks found on animals. Mosquitoes spread the dengue virus.

Due to this, it is important to avoid unnecessary contact with cattle or uncooked meat and regularly disinfect animals to eliminate ticks, according to Badawood.

He also recommended wearing gloves while handling raw meat at home.

He advised against drinking milk that is not pasteurized, particularly after milking cows.

Anyone who displays symptoms of Al-Khurma fever is being urged to visit the nearest medical center. Medical staff should also be informed if any recent contact has been made with animals or uncooked meat.

The director also noted that the disease has incorrectly been called Al-Khamra fever by some media.

"The correct name is Al-Khurma fever which is attributed to Al-Khurma, a town near Taif where the virus was first detected in goats in 1994," the director said.

Six people in Jeddah contracted the disease that year.

While there is no evidence of mosquitoes carrying the disease, there is a likelihood that domestic pets carrying ticks could transmit the disease to humans.
 
Re: Saudi Arabia: Al-Khurma virus back in Jeddah

Source: http://www.saudigazette.com.sa/index.cfm?method=home.regcon&contentID=2010011360023

It?s Al-Khurma, not Al-Khumra, says official
JEDDAH ? The head of Jeddah Health Affairs has said that the correct name for the potentially fatal virus that was reported nine days ago as having hospitalized four persons in the city is ?Al-Khurma?, and not ?Al-Khumra? as reported in the local media.
Sami Badawood also said the Al-Khurma virus made its first appearance with six cases in Jeddah in 1994 and was named at the time after the source, identified as ?goats from the Taif region of Al-Khurma?, thereby refuting claims from other quarters that it was derived from the Al-Khumra District of Jeddah where some cases had been detected.
According to Al-Watan Arabic daily on Tuesday, Badawood also refuted suggestions that the illness was passed on by mosquitoes.
?The Al-Khurma virus is passed on to humans by mites that live in animal pens for sheep, goats and camels, and pets such as cats and rabbits can also carry the mites that have the disease,? Badawood was reported as saying at a press conference on Monday. ?There is no scientific evidence that the illness is passed on through mosquitoes.?
It was also revealed that the four persons recently treated for the virus were first discovered to be infected three weeks ago, and that one was butcher.
Saudi Gazette reported this week that four cases of the misnamed ?Al-Khumra? virus had been detected in residents of the north of Jeddah. Minister of Health Abdullah Al-Rabeah described the cases as ?only individual instances which were immediately treated.?
Dr. Tariq Madani, a contagious disease specialist from King Abdulaziz University, said the virus remained relatively unknown and that it still had no vaccination or single cure. It was, he said, ?more dangerous than Rift Valley Fever?, and ?fatal for one in four.?
Madani said that symptoms of the virus were a high fever, inflammation of the liver and brain, and bleeding from the gums, nose, stomach, anus, womb, urinary tract or skin.
? SG
 
Re: Saudi Arabia: Al-Khurma virus back in Jeddah

http://www.promedmail.org/pls/otn/f..._BACK_PAGE,F2400_P1001_PUB_MAIL_ID:1000,81040

Archive Number 20100123.0254
Published Date 23-JAN-2010
Subject PRO/AH/EDR> Alkhurma virus - Saudi Arabia (02): (MK) correction


ALKHURMA VIRUS - SAUDI ARABIA (02): (MAKKAH) CORRECTION
*******************************************************
A ProMED-mail post
<http://www.promedmail.org>
ProMED-mail is a program of the
International Society for Infectious Diseases
<http://www.isid.org>

Date: Fri 22 Nov 2010
From: Shamsudeen Fagbo, DVM
<oloungbo@yahoo.com>


Kindly permit our comments on: Alkhurma virus - Saudi Arabia: (MK)
20100106.0056

In the 1st place, the recent 4 cases of Alkhurma hemorrhagic fever (AHF)
were NOT detected in January 2010. All the cases were linked to last year's
Hajj and diagnosed in the post Hajj period (late November/early December
2009). The date of exposure (22 Nov 2009) to the risk factor -- the
slaughtering or processing of slaughtered sheep -- was shared by all 4
cases. These unrelated cases were all diagnosed in different private
hospitals in Jeddah
. Alkhurma hemorrhagic fever virus (AHFV) RNA was
detected at the Ministry of Health (MOH) Jeddah virology lab. Their
symptoms were successfully managed: they were discharged prior to the end
of last year [2009].


Secondly, only one of the patients resides north of Jeddah. One of the
other patients was a Taif-based butcher who slaughtered and processed sheep
in Makkah during the last Hajj season. He came to Jeddah to seek medical
attention for his illness. He could have had multiple, continuous exposures
to potentially infected animals. As such, these cases are in no way
clustered as the report suggests
.

Thirdly, since an enhanced surveillance system was hitherto not in place,
it cannot be said that AHFV was absent for 15 years. Presently, the viral
hemorrhagic fever (VHF) surveillance in Jeddah is being enhanced to ensure
prompt clinical dengue virus infection: the MOH is immediately notified of
suspected dengue cases occurring in private and government health care
settings. Clinical dengue and AHF share symptoms and are considered
differential diagnoses for one another in this region. Clinically suspected
but laboratory negative dengue cases were tested for AHFV. All suspected
VHF cases are now tested simultaneously for dengue and AHFV infection.

As part of this enhanced surveillance, and 2 months prior to the last Hajj
season, blood samples of patients with clinically suspected dengue but
negative lab results (dengue IgM and IgG, dengue antigen test NS1 and PCR)
were further tested for chikungunya, Rift Valley fever, West Nile fever and
Alkhurma at the Jeddah virology lab. All tests were negative. In the past,
there have been clinically suspected dengue cases that were laboratory
negative by IgG and IgM serology as well as PCR. These cases were not
tested for AHFV infection (Ayyub, et al. 2006; Khan, et al. 2008).

The MOH, drawing on presently available scientific data, concurs that AHFV
is a tickborne virus and a genetic variant of the Kyasanur Forest disease
virus. With this in mind, it is making concerted multidisciplinary efforts
to further our understanding of AHFV epidemiology and facilitate
evidence-based prevention. If it were mosquitoborne, the time lag between
exposure and clinical onset in these 4 cases would have ensured that
mosquitoes in their neighbourhoods were infected and thereby infected
others. Additionally, all the 4 cases were adults (range: 39-56; mean: 46):
there arises the entomological quagmire as to why our local mosquitoes
preferentially bite adults in a community where children and the young are
in greater numbers. Dengue, the main differential diagnosis for AHF as well
as the predominant mosquitoborne virus in the region, is known to affect
mostly the young (Ayyub, et al. 2006; Khan, et al. 2008).

In contrast, our epidemiological investigation indicated that the 4
patients were exposed to infected animal during slaughtering or meat
processing. Efforts to trace the source of sheep slaughtered for 3 cases
have so far been unsuccessful: though the sheep market was identified, poor
documentation of animal sales and movement stalled our efforts. Not
unexpected, there was hard tick infestation of goats, sheep and camels in
the market.

In summary, the present outbreak of the AHFV is sporadic and the potential
for spread highly limited. The MOH and the Ministry of Agriculture are
fully collaborating and following developments.

References
----------
Ayyub M, Khazindar AM, Lubbad EH, Barlas S, Alfi AY, Al-Ukayli S.
Characteristics of dengue fever in a large public hospital, Jeddah, Saudi
Arabia. J Ayub Med Coll Abbottabad 2006 Apr-Jun; 18(2): 9-13.
Khan NA, Azhar EI, El-Fiky S, Madani HH, Abuljadial MA, Ashshi AM, et al.
Clinical profile and outcome of hospitalized patients during first outbreak
of dengue in Makkah, Saudi Arabia. Acta Trop 2008 Jan; 105(1): 39-44.

--
Ziad A Memish MD, FRCPC, FACP
Assistant Deputy Minister for Preventive Medicine
Shamsudeen F Fagbo DVM
Zoonotic Diseases Unit
Directorate of Communicable Diseases
Ministry of Health Riyadh 11176
Kingdom of Saudi Arabia
Noha A Dashash MB BS, DPHC, ABFM, SBFM
Naeema A Akbar MD, PD, FETP, ABCM, RICR
Ghaiath M Hussein MB BS, MHSc
Primary Health care and Preventive Medicine (MOH)
Jeddah

[ProMED-mail thanks Drs Memish, Fagbo, Dashhash, Akbar, and Hussein for
their correction of the earlier report of 6 Jan 2010 (archive number
20100106.0056), with comments based on the MOH's thorough epidemiological
investigation of the 4 cases of Alkhurma virus infection. The results of
their concerted multidisciplinary efforts to further understanding of AHFV
epidemiology and facilitate prevention are awaited with interest.

Jeddah, on the coast of the Red Sea, can be located on the map at
<http://www.lib.utexas.edu/maps/middle_east_and_asia/saudi_arabia_pol_2003.pdf>.
A HealthMap/ProMED-mail interactive map of Saudi Arabia can be accessed at
<http://healthmap.org/r/011Z>. - Mod.TY]

[see also:
Alkhurma virus - Saudi Arabia: (MK) 20100106.0056
2004
---
Alkhurma virus, human death - Saudi Arabia (02) 20040309.0666
Alkhurma virus, human death - Saudi Arabia 20040302.0631
2003
---
Dengue/DHF update 2003 (09) 20030303.0532
Tick-borne flavivirus - Saudi Arabia 20020509.4144
1997
---
Encephalitis, tickborne - Saudi Arabia 19970907.1921
Encephalitis, tickborne - Saudi Arabia (02) 19970907.1933
Encephalitis, tickborne - Saudi Arabia (03) 19970914.1959
Encephalitis, tickborne - Saudi Arabia (04) 19970914.1963
Encephalitis, Tickborne - Saudi Arabia (05) 19970916.1967
Encephalitis, tickborne - Saudi Arabia (06) 19970917.1973

........................ty/ejp/sh
 
Re: Saudi Arabia: Al-Khurma virus back in Jeddah

Source: http://www.saudigazette.com.sa/index.cfm?method=home.regcon&contentID=2010020161985

7 cases of Al-Khurma flu no cause for alarm
By Nawaf Afit
RIYADH ? The Ministry of Health has confirmed seven cases of the Al-Khurma hemorrhagic influenza in Makkah and Najran, but this was not cause for any alarm, according to Health Minister Dr. Abdullah Al-Rabeah.
He said that there was a high rate of recovery from the flu even though there is no specific medicine to treat sufferers.
Al-Rabeah was speaking in Riyadh Sunday at the launch of an international scientific workshop which was being held to formulate a plan to counter the Al-Khurma disease. Also present at the event was Dr. Fahd Balghunaim, Minister of Agriculture.
Al-Rabeah assured the public that there was no need to be concerned because there have only been a limited number of people afflicted with the disease since 1994.
He said the workshop was being held in terms of royal directives to take preventative measures against the disease.
?The ministry and related authorities have taken many preventive and precautionary measures against the Al-Khurma disease,? he said.
Al-Rabeah said that joint committees and working teams consisting of experts from the Kingdom and abroad have been formed to develop a national plan for countering the Al-Khurma hemorrhagic flu.
The teams would determine the epidemiological characteristics of the disease, the way it is transmitted, and develop methods of combating and controlling the disease and preventing it from spreading.
In his speech, Balghunaim dealt with the support the leadership provides to the health sector. He said the participation of the Ministry of Agriculture in efforts to counter the disease was a national duty.
Dr. Ziyad Meimish, Assistant Undersecretary of the Ministry of Health for Preventive Medicine, gave a brief history of the disease. Then the participants were divided into working groups to discuss the national plan.
The Al-Khurma virus is passed on to humans by ticks that live in animals such as sheep, goats and camels. Pets such as cats and rabbits can also carry the ticks.
Preventive measures include wearing gloves when handling raw uncooked meat. Also, livestock should be checked periodically to ensure that they are free of ticks. Suitable insecticides should be used to kill the insects on the animals. Furthermore, people should not drink un-pasteurized milk. ? Okaz/SG
 
Re: Saudi Arabia: Al-Khurma virus back in Jeddah

Source: http://www.saudigazette.com.sa/index.cfm?method=home.regcon&contentID=2010020161985

7 cases of Al-Khurma flu no cause for alarm
By Nawaf Afit
RIYADH – The Ministry of Health has confirmed seven cases of the Al-Khurma hemorrhagic influenza in Makkah and Najran,

Umm. Yikes. This virus is NOT influenza. We do NOT want to start calling it hemorrhagic influenza (or camel influenza or any other kind of animal influenza). We saw how Egypt reacted to "goat flu" - I can only imagine the reaction this one will generate.
 
Re: Saudi Arabia: Al-Khurma virus back in Jeddah

See the red comments. Very nice.

http://www.promedmail.org/pls/otn/f..._BACK_PAGE,F2400_P1001_PUB_MAIL_ID:1000,81163

Archive Number 20100202.0351
Published Date 02-FEB-2010
Subject PRO/AH/EDR> Alkhurma virus - Saudi Arabia (03): (MK, NJ)


ALKHURMA VIRUS - SAUDI ARABIA (03): (MAKKAH, NAJRAN)
****************************************************
A ProMED-mail post
<http://www.promedmail.org>
ProMED-mail is a program of the
International Society for Infectious Diseases
<http://www.isid.org>

Date: Mon 1 Feb 2010
Source: The Saudi Gazette [edited]
<http://www.saudigazette.com.sa/index.cfm?method=home.regcon&contentID=2010020161985&archiveissuedate=01/02/2010>


7 cases of Alkhurma flu [sic] no cause for alarm
------------------------------------------------
The Ministry of Health has confirmed 7 cases of the Alkhurma
hemorrhagic influenza in Makkah [Mecca] and Najran, but this was not
cause for alarm, according to Health Minister Dr Abdullah Al-Rabeah.
He said that there was a high rate of recovery from the flu even
though there is no specific medicine to treat sufferers. [It is
unfortunate that these cases are designated "flu", because Alkhurma
virus is a flavivirus totally unrelated to influenza virus.
Designating it as "flu" only serves to confuse the public. - Mod.TY]


Al-Rabeah was speaking in Riyadh Sunday [31 Jan 2010] at the launch of
an international scientific workshop being held to formulate a plan to
counter the Alkhurma disease. Also present at the event was Dr Fahd
Balghunaim, minister of agriculture.

Al-Rabeah assured the public that there was no need to be concerned
because there has only been a limited number of people afflicted with
the disease since 1994.

He said the workshop was being held in terms of royal directives to
take preventive measures against the disease. "The ministry and
related authorities have taken many preventive and precautionary
measures against the Alkhurma disease," he said. Al-Rabeah said that
joint committees and working teams consisting of experts from the
Kingdom and abroad have been formed to develop a national plan for
countering the Alkhurma hemorrhagic flu.

The teams would determine the epidemiological characteristics of the
disease, the way it is transmitted, and develop methods of combating
and controlling the disease and preventing it from spreading.

In his speech, Balghunaim dealt with the support the leadership
provides to the health sector. He said the participation of the
Ministry of Agriculture in efforts to counter the disease was a
national duty.

Dr Ziyad Meimish, assistant undersecretary of the Ministry of Health
for Preventive Medicine, gave a brief history of the disease. Then the
participants were divided into working groups to discuss the national
plan.

The Alkhurma virus is passed on to humans by ticks that live on
animals such as sheep, goats, and camels. Pets such as cats and
rabbits can also carry the ticks.

Preventive measures include wearing gloves when handling raw uncooked
meat. Also, livestock should be checked periodically to ensure that
they are free of ticks. Suitable insecticides should be used to kill
the insects [ticks are not insects. - Mod.JW] on the animals.
Furthermore, people should not drink unpasteurized milk [since related
flaviviruses can be transmitted through the milk of infected
livestock. - Mod.JW].

[Byline: Nawaf Afit]

--
Communicated by:
ProMED-mail
<promed@promedmail.org>
 
Re: Saudi Arabia: Al-Khurma virus back in Jeddah

Source: http://www.saudigazette.com.sa/index.cfm?method=home.regcon&contentID=2010020862747

Committee formed to combat Khurma fever

RIYADH ? Dr. Abdul Aziz Al-Rabea, Minister of Health, has ordered the formation of a multi-dimentional National Committee for the prevention of Al-Khurma fever, Dr. Khalid Marghlani, the ministry spokesperson said here Sunday.
Dr. Ziayd Ahmed Meemesh, Undersecretary for Preventive Medicine in the ministry would head the committee, Marghlani said.
The committee has been tasked with following up updates on Al-Khurma virus.
It will also participate in the development of plans and recommendations for combating the disease, its prevention and its awareness, said Marghlani.
The virus (genus Flavivirus, AHFV) was recently identified as the agent of a viral hemorrhagic fever in Saudi Arabia and characterized serologically and genetically as a variant genotype of Kyasanur Forest disease virus (KFDV).
Since viral diagnosis and vaccine development may be hindered by genetic diversity, this study was intended to address AHFV genetic heterogeneity.
Eleven strains isolated from hospitalized patients from 1994 to 1999 in Saudi Arabia were sequenced in the envelope, NS3, and NS5 genes. Homologous sequences were compared and used to look for patterns reflecting specific evolution associated with spatiality, temporality, infection pathway, and disease prognosis.
Genetic analyses showed low diversity, which suggests a slow microevolution.
Evaluation of divergence times showed that AHFV and KFDV ancestral lineage diverged 66-77 years ago, and the diversity observed within the studied AHFV strains reflected a 4 to 72-year period of evolution.
Earlier last week, Dr. Al-Rabea launched an international workshop on the national plan to discuss Al-Khurma fever with participation of experts from the World Health Organization. ? SPA
 
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