tetano
Editor, Senior Moderator
SAGE Open Med
. 2021 Mar 21;9:20503121211002996.
doi: 10.1177/20503121211002996. eCollection 2021.
Hypercoagulability in COVID-19: A review of the potential mechanisms underlying clotting disorders
Walid Alam[SUP] 1 [/SUP]
Affiliations
Abstract
Severe acute respiratory syndrome coronavirus-2 has emerged as a new viral pandemic, causing Coronavirus disease 2019 (COVID-19) leading to a wide array of symptoms ranging from asymptomatic to severe respiratory failure. However, coagulation disorders have been found in some patients infected with SARS-CoV-2, leading to either a clotting disorder or hemorrhage. Several mechanisms attempt to explain the mechanism behind the pro-coagulant state seen with COVID-19 patients, including different receptor binding, cytokine storm, and direct viral endothelial damage. SARS-CoV-2 has also been recently found to bind to CLEC4M receptor, a receptor that participates in the clearance of von Willebrand Factor and Factor VIII. The competitive binding of SARS-CoV-2 to CLEC4M could lead to decreased clearance, and therefore a promotion of a pro-coagulative state; however, an experimental study needs to be done to prove such an association.
Keywords: CLEC4M; COVID-19; SARS-CoV-2; coagulopathy; fibrinolytic shutdown; infectious diseases; mechanism.
. 2021 Mar 21;9:20503121211002996.
doi: 10.1177/20503121211002996. eCollection 2021.
Hypercoagulability in COVID-19: A review of the potential mechanisms underlying clotting disorders
Walid Alam[SUP] 1 [/SUP]
Affiliations
- PMID: 33815798
- PMCID: PMC7989108
- DOI: 10.1177/20503121211002996
Abstract
Severe acute respiratory syndrome coronavirus-2 has emerged as a new viral pandemic, causing Coronavirus disease 2019 (COVID-19) leading to a wide array of symptoms ranging from asymptomatic to severe respiratory failure. However, coagulation disorders have been found in some patients infected with SARS-CoV-2, leading to either a clotting disorder or hemorrhage. Several mechanisms attempt to explain the mechanism behind the pro-coagulant state seen with COVID-19 patients, including different receptor binding, cytokine storm, and direct viral endothelial damage. SARS-CoV-2 has also been recently found to bind to CLEC4M receptor, a receptor that participates in the clearance of von Willebrand Factor and Factor VIII. The competitive binding of SARS-CoV-2 to CLEC4M could lead to decreased clearance, and therefore a promotion of a pro-coagulative state; however, an experimental study needs to be done to prove such an association.
Keywords: CLEC4M; COVID-19; SARS-CoV-2; coagulopathy; fibrinolytic shutdown; infectious diseases; mechanism.