tetano
Editor, Senior Moderator
SAGE Open Med Case Rep
. 2020 Dec 25;8:2050313X20983132.
doi: 10.1177/2050313X20983132. eCollection 2020.
Clinical, electromyographical, histopathological characteristics of COVID-19 related rhabdomyolysis
Chiara Rosato[SUP] 1 [/SUP], Giuliano Bolondi[SUP] 1 [/SUP], Emanuele Russo[SUP] 1 [/SUP], Alessandro Oliva[SUP] 1 [/SUP], Giovanni Scognamiglio[SUP] 1 [/SUP], Emanuele Mambelli[SUP] 2 [/SUP], Marco Longoni[SUP] 3 [/SUP], Giulio Rossi[SUP] 4 [/SUP], Vanni Agnoletti[SUP] 1 [/SUP]
Affiliations
Abstract
Rhabdomyolysis is an uncommon complication of the coronavirus disease 2019 (COVID-19) infection. Previous reports have described its management and treatment in medical units, but have not discussed confirmatory tests or differential diagnosis. We report a case of a 58 year-old male patient, who was admitted for COVID-19 pneumonia and subsequently developed severe weakness, inability to move limbs, acute renal failure, significantly elevated myoglobin and creatinine kinase, and was diagnosed with rhabdomyolysis. Continuous renal replacement therapy, the treatment modality of choice over hyperhydration due to ongoing mechanical ventilation, was effective in resolving symptoms. No direct viral invasion of muscles was noted on biopsy. Here, we describe his symptoms, electromyography, and muscular biopsy results, and further discuss the possible differential diagnoses. Neuromuscular symptoms related to COVID-19 require careful clinical analysis. In addition, detailed reports of patients' course of illness and diagnoses will assist in improving care for affected patients.
Keywords: Acute kidney injury; Guillain-Barr? syndrome; biopsy; central nervous system; critical illness; electromyography; intensive care units; muscle weakness.
. 2020 Dec 25;8:2050313X20983132.
doi: 10.1177/2050313X20983132. eCollection 2020.
Clinical, electromyographical, histopathological characteristics of COVID-19 related rhabdomyolysis
Chiara Rosato[SUP] 1 [/SUP], Giuliano Bolondi[SUP] 1 [/SUP], Emanuele Russo[SUP] 1 [/SUP], Alessandro Oliva[SUP] 1 [/SUP], Giovanni Scognamiglio[SUP] 1 [/SUP], Emanuele Mambelli[SUP] 2 [/SUP], Marco Longoni[SUP] 3 [/SUP], Giulio Rossi[SUP] 4 [/SUP], Vanni Agnoletti[SUP] 1 [/SUP]
Affiliations
- PMID: 33489234
- PMCID: PMC7768562
- DOI: 10.1177/2050313X20983132
Abstract
Rhabdomyolysis is an uncommon complication of the coronavirus disease 2019 (COVID-19) infection. Previous reports have described its management and treatment in medical units, but have not discussed confirmatory tests or differential diagnosis. We report a case of a 58 year-old male patient, who was admitted for COVID-19 pneumonia and subsequently developed severe weakness, inability to move limbs, acute renal failure, significantly elevated myoglobin and creatinine kinase, and was diagnosed with rhabdomyolysis. Continuous renal replacement therapy, the treatment modality of choice over hyperhydration due to ongoing mechanical ventilation, was effective in resolving symptoms. No direct viral invasion of muscles was noted on biopsy. Here, we describe his symptoms, electromyography, and muscular biopsy results, and further discuss the possible differential diagnoses. Neuromuscular symptoms related to COVID-19 require careful clinical analysis. In addition, detailed reports of patients' course of illness and diagnoses will assist in improving care for affected patients.
Keywords: Acute kidney injury; Guillain-Barr? syndrome; biopsy; central nervous system; critical illness; electromyography; intensive care units; muscle weakness.