tetano
Editor, Senior Moderator
BJOG. 2015 Mar 6. doi: 10.1111/1471-0528.13329. [Epub ahead of print]
[h=1]Safety of vaccination against influenza A (H1N1) during pregnancy in the Netherlands: results on pregnancy outcomes and infant's health: cross-sectional linkage study.[/h] van der Maas N[SUP]1[/SUP], Dijs-Elsinga J, Kemmeren J, van Lier A, Knol M, de Melker H.
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]OBJECTIVE:[/h] This study aims to assess the safety of Influenza A(H1N1), vaccination administered during the second and third trimester and containing MF59 and thiomersal (Focetria[SUP]?[/SUP] ), measured by pregnancy outcomes and infant's health.
[h=4]DESIGN:[/h] Cross-sectional linkage study.
[h=4]SETTING AND SAMPLE:[/h] A sample of pregnant women, eligible for prenatal screening, were invited to participate.
[h=4]METHODS:[/h] Questionnaire data were linked with the Netherlands Perinatal Registry (n = 1920). Information on infant growth, development (n = 1739) and infection-related contacts with the general practitioner (GP) during the first year of life (n = 1671) was obtained.
[h=4]MAIN OUTCOME MEASURES:[/h] Multivariate logistic regression was used to assess the association between H1N1 vaccination and small-for-gestational-age infant, preterm delivery and a composite adverse outcome, i.e. low Apgar-score, neonatal intensive care unit admission, neonatal resuscitation or perinatal death. Influence of maternal vaccination on growth, development and GP infection-related contact rates were assessed using multivariate linear mixed modelling and multivariate negative binomial regression, respectively.
[h=4]RESULTS:[/h] Response rate was 21%. Though we found differences in characteristics between unvaccinated and vaccinated women, in the multivariate analyses no association was found between H1N1 vaccination and small-for-gestational-age (odds ratio [OR] 0.84; 95% confidence interval [95% CI] 0.50-1.43), preterm delivery (OR 0.98; 95% CI 0.59-1.62) and the composite adverse outcome (OR 0.84; 95% CI 0.44-1.60). We found no differences in weight-for-age (-0.05; 95% CI -0.13 to 0.04), length-for-age (-0.01; 95% CI -0.09 to 0.06), head-circumference-for-age (-0.05; 95% CI -0.13 to 0.03), developmental scores (-0.06; 95% CI -0.28 to 0.17) and infection-related GP contact rates (incidence rate ratio 1.07; 95% CI 0.91-1.28) between infants of unvaccinated and vaccinated mothers.
[h=4]CONCLUSION:[/h] Pregnancy outcomes did not differ between H1N1-vaccinated and unvaccinated women. Furthermore, growth, development and GP infection-related contact rates, assessed after the first year of life, were similar in offspring of vaccinated and unvaccinated mothers.
? 2015 Royal College of Obstetricians and Gynaecologists.
[h=4]KEYWORDS:[/h] Infant; influenza; pregnancy; safety; vaccination
PMID: 25754741 [PubMed - as supplied by publisher]
[h=1]Safety of vaccination against influenza A (H1N1) during pregnancy in the Netherlands: results on pregnancy outcomes and infant's health: cross-sectional linkage study.[/h] van der Maas N[SUP]1[/SUP], Dijs-Elsinga J, Kemmeren J, van Lier A, Knol M, de Melker H.
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]OBJECTIVE:[/h] This study aims to assess the safety of Influenza A(H1N1), vaccination administered during the second and third trimester and containing MF59 and thiomersal (Focetria[SUP]?[/SUP] ), measured by pregnancy outcomes and infant's health.
[h=4]DESIGN:[/h] Cross-sectional linkage study.
[h=4]SETTING AND SAMPLE:[/h] A sample of pregnant women, eligible for prenatal screening, were invited to participate.
[h=4]METHODS:[/h] Questionnaire data were linked with the Netherlands Perinatal Registry (n = 1920). Information on infant growth, development (n = 1739) and infection-related contacts with the general practitioner (GP) during the first year of life (n = 1671) was obtained.
[h=4]MAIN OUTCOME MEASURES:[/h] Multivariate logistic regression was used to assess the association between H1N1 vaccination and small-for-gestational-age infant, preterm delivery and a composite adverse outcome, i.e. low Apgar-score, neonatal intensive care unit admission, neonatal resuscitation or perinatal death. Influence of maternal vaccination on growth, development and GP infection-related contact rates were assessed using multivariate linear mixed modelling and multivariate negative binomial regression, respectively.
[h=4]RESULTS:[/h] Response rate was 21%. Though we found differences in characteristics between unvaccinated and vaccinated women, in the multivariate analyses no association was found between H1N1 vaccination and small-for-gestational-age (odds ratio [OR] 0.84; 95% confidence interval [95% CI] 0.50-1.43), preterm delivery (OR 0.98; 95% CI 0.59-1.62) and the composite adverse outcome (OR 0.84; 95% CI 0.44-1.60). We found no differences in weight-for-age (-0.05; 95% CI -0.13 to 0.04), length-for-age (-0.01; 95% CI -0.09 to 0.06), head-circumference-for-age (-0.05; 95% CI -0.13 to 0.03), developmental scores (-0.06; 95% CI -0.28 to 0.17) and infection-related GP contact rates (incidence rate ratio 1.07; 95% CI 0.91-1.28) between infants of unvaccinated and vaccinated mothers.
[h=4]CONCLUSION:[/h] Pregnancy outcomes did not differ between H1N1-vaccinated and unvaccinated women. Furthermore, growth, development and GP infection-related contact rates, assessed after the first year of life, were similar in offspring of vaccinated and unvaccinated mothers.
? 2015 Royal College of Obstetricians and Gynaecologists.
[h=4]KEYWORDS:[/h] Infant; influenza; pregnancy; safety; vaccination
PMID: 25754741 [PubMed - as supplied by publisher]