tetano
Editor, Senior Moderator
Mod Rheumatol. 2012 Feb 11. [Epub ahead of print]
Safety and response to influenza vaccine in patients with systemic-onset juvenile idiopathic arthritis receiving tocilizumab.
Shinoki T, Hara R, Kaneko U, Miyamae T, Imagawa T, Mori M, Yokota S.
Source
Department of Pediatrics, Suzuka Central General Hospital, 1275-53 Yamanohana, Yasuzuka-cho, Suzuka, Mie, 513-8630, Japan, suimp4wd@yahoo.co.jp.
Abstract
OBJECTIVE:
We investigated the safety and efficacy of administering influenza vaccines to patients with systemic-onset juvenile idiopathic arthritis (sJIA) treated with tocilizumab.
PATIENTS AND METHODS:
The subjects were 27 sJIA patients treated with tocilizumab and 17 healthy age- and sex-matched volunteers. Serum samples were collected prior to and 4-7 weeks after vaccination. Hemagglutination inhibition values of the vaccine were taken as the antibody titers. The duration of tocilizumab administration and the daily doses of prednisolone per unit body weight were analyzed to identify factors affecting the responses of the sJIA patients to influenza vaccination. We questioned all the subjects about whether they had contracted influenza and whether they had had adverse reactions to the influenza vaccination. We compared steroid doses in sJIA patients before and after vaccination to document any worsening of the underlying disease.
RESULTS:
The efficacy of influenza vaccination did not differ significantly between the sJIA group and the healthy controls. The duration of tocilizumab administration did not affect the response of the sJIA patients to the influenza vaccination. None of the sJIA patients experienced either severe adverse reactions or disease exacerbation after the influenza vaccination.
CONCLUSION:
We found that sJIA patients treated with tocilizumab could be effectively and safely immunized with the influenza vaccine.
PMID:
22322589
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22322589
Safety and response to influenza vaccine in patients with systemic-onset juvenile idiopathic arthritis receiving tocilizumab.
Shinoki T, Hara R, Kaneko U, Miyamae T, Imagawa T, Mori M, Yokota S.
Source
Department of Pediatrics, Suzuka Central General Hospital, 1275-53 Yamanohana, Yasuzuka-cho, Suzuka, Mie, 513-8630, Japan, suimp4wd@yahoo.co.jp.
Abstract
OBJECTIVE:
We investigated the safety and efficacy of administering influenza vaccines to patients with systemic-onset juvenile idiopathic arthritis (sJIA) treated with tocilizumab.
PATIENTS AND METHODS:
The subjects were 27 sJIA patients treated with tocilizumab and 17 healthy age- and sex-matched volunteers. Serum samples were collected prior to and 4-7 weeks after vaccination. Hemagglutination inhibition values of the vaccine were taken as the antibody titers. The duration of tocilizumab administration and the daily doses of prednisolone per unit body weight were analyzed to identify factors affecting the responses of the sJIA patients to influenza vaccination. We questioned all the subjects about whether they had contracted influenza and whether they had had adverse reactions to the influenza vaccination. We compared steroid doses in sJIA patients before and after vaccination to document any worsening of the underlying disease.
RESULTS:
The efficacy of influenza vaccination did not differ significantly between the sJIA group and the healthy controls. The duration of tocilizumab administration did not affect the response of the sJIA patients to the influenza vaccination. None of the sJIA patients experienced either severe adverse reactions or disease exacerbation after the influenza vaccination.
CONCLUSION:
We found that sJIA patients treated with tocilizumab could be effectively and safely immunized with the influenza vaccine.
PMID:
22322589
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22322589