tetano
Editor, Senior Moderator
J Infect Dis. 2015 Feb 23. pii: jiv087. [Epub ahead of print]
[h=1]Safety and Immunogenicity of a Single Low or High Dose of Clade 2 H5N1 Inactivated Influenza Vaccine in Adults Previously Primed with Clade 1 H5N1 Vaccine.[/h] Winokur PL[SUP]1[/SUP], Patel SM[SUP]2[/SUP], Brady R[SUP]3[/SUP], Chen WH[SUP]4[/SUP], El-Kamary SS[SUP]4[/SUP], Edwards K[SUP]5[/SUP], Creech CB[SUP]5[/SUP], Frey S[SUP]6[/SUP], Keitel WA[SUP]7[/SUP], Belshe R[SUP]6[/SUP], Walter E[SUP]8[/SUP], Bellamy A[SUP]9[/SUP], Hill H[SUP]9[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] H5N1 influenza vaccination strategies that improve the immunological speed and cross-clade protection are desired. We compared the immunogenicity of a single 15 or 90 mcg dose of A/H5N1/Indonesia/05/05 (Clade 2) vaccine in adults who were previously primed with A/H5N1/Vietnam/1203/2004 (Clade 1) vaccine. High dose vaccine resulted in significantly higher titers to both clade 1 and 2 antigens. Clade 2 titers were unaffected by the previous dose of clade 1 vaccine. Low dose priming with a mismatched pandemic H5N1 vaccine would improve the rapidity, magnitude and cross reactivity of the immunological response following a single high dose, unadjuvanted, pandemic vaccine.
? The Author 2015. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.
PMID: 25712967 [PubMed - as supplied by publisher]
[h=1]Safety and Immunogenicity of a Single Low or High Dose of Clade 2 H5N1 Inactivated Influenza Vaccine in Adults Previously Primed with Clade 1 H5N1 Vaccine.[/h] Winokur PL[SUP]1[/SUP], Patel SM[SUP]2[/SUP], Brady R[SUP]3[/SUP], Chen WH[SUP]4[/SUP], El-Kamary SS[SUP]4[/SUP], Edwards K[SUP]5[/SUP], Creech CB[SUP]5[/SUP], Frey S[SUP]6[/SUP], Keitel WA[SUP]7[/SUP], Belshe R[SUP]6[/SUP], Walter E[SUP]8[/SUP], Bellamy A[SUP]9[/SUP], Hill H[SUP]9[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] H5N1 influenza vaccination strategies that improve the immunological speed and cross-clade protection are desired. We compared the immunogenicity of a single 15 or 90 mcg dose of A/H5N1/Indonesia/05/05 (Clade 2) vaccine in adults who were previously primed with A/H5N1/Vietnam/1203/2004 (Clade 1) vaccine. High dose vaccine resulted in significantly higher titers to both clade 1 and 2 antigens. Clade 2 titers were unaffected by the previous dose of clade 1 vaccine. Low dose priming with a mismatched pandemic H5N1 vaccine would improve the rapidity, magnitude and cross reactivity of the immunological response following a single high dose, unadjuvanted, pandemic vaccine.
? The Author 2015. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.
PMID: 25712967 [PubMed - as supplied by publisher]