tetano
Editor, Senior Moderator
Org Biomol Chem. 2015 Oct 14. [Epub ahead of print]
[h=1]S-Linked sialyloligosaccharides bearing liposomes and micelles as influenza virus inhibitors.[/h] Yeh HW[SUP]1[/SUP], Lin TS, Wang HW, Cheng HW, Liu DZ, Liang PH.
[h=3]Author information[/h]
[h=3]Abstract[/h] An efficient, homogeneous synthesis of phospholipid conjugation of S-Neu5Acα2-6Galβ1-4GluNAcβ1-3 () and its 6-sulphate analogue has been developed. The self-assembled micelles and liposomes of these trisaccharides formed in solution were found to be inhibitors interfering with the entry of the H1N1 influenza virus into MDCK cells. Compound bearing a liposome and a micelle displayed superior inhibitory activity than its 6-sulfate congener in both the virus neutralization assay and the hemagglutination inhibition assay.
PMID: 26464117 [PubMed - as supplied by publisher]
[h=1]S-Linked sialyloligosaccharides bearing liposomes and micelles as influenza virus inhibitors.[/h] Yeh HW[SUP]1[/SUP], Lin TS, Wang HW, Cheng HW, Liu DZ, Liang PH.
[h=3]Author information[/h]
[h=3]Abstract[/h] An efficient, homogeneous synthesis of phospholipid conjugation of S-Neu5Acα2-6Galβ1-4GluNAcβ1-3 () and its 6-sulphate analogue has been developed. The self-assembled micelles and liposomes of these trisaccharides formed in solution were found to be inhibitors interfering with the entry of the H1N1 influenza virus into MDCK cells. Compound bearing a liposome and a micelle displayed superior inhibitory activity than its 6-sulfate congener in both the virus neutralization assay and the hemagglutination inhibition assay.
PMID: 26464117 [PubMed - as supplied by publisher]