Russian scientists evolve anti-bird flu drug

[Niko]

<table border="0" cellpadding="0" cellspacing="0" width="100%"><tbody><tr><td>Russian scientists evolve anti-bird flu drug

19.03.2007, 13.28


</td></tr> <tr class="news"><td style="text-align: justify;"> ST. PETERSBURG, March 19 (Itar-Tass) - Scientists of the St. Petersburg Grippe Research Institute of the Russian Academy of Medical Sciences, jointly with their colleagues in the Organic Synthesis Institute of the Urals Section of the Russian Academy of Sciences, have evolved an absolutely new anti-virus drug with a broad range of application, which is even able to neutralise the highly pathogenetic H5-N1 bird flu virus. The preparation is ready for state registration, Director of the Academy?s St. Petersburg Institute Academician Oleg Kiselev stated on Monday, delivering a lecture to his colleagues at the British Council on ?Bird Flu and Prevention of a Pandemia?.

Kiselev stressed that this ?innovatory Russian drug, called Triazoverin, was far superior to the broadly known foreign Tamiflu drugs from the pharmacological point of view. Moreover, the action of the Russian drug is beyond match anywhere abroad, since it does not depend on the gravity or phase of the infection process, he stated.

Kiselev said his colleagues assess the Triazoverin drug as ?a major achievement of Russian science and a result of fruitful cooperation of the two leading institutes of the Russian Academy of Sciences and the Russian Academy of Medical Sciences?. Director of the WHO Reference Centre for Influenza of the London National Institute for Medical Research Alan Hay has highly praised the work of his Russian colleagues.

The drug innovation project has won the contest for financial assistance from the Russian Ministry of Education and Science of the Russian Federation.
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http://www.itar-tass.com/eng/level2.html?NewsID=11349280&PageNum=0
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</td></tr></tbody></table>Links to Oleg Kiselev at FT:
http://www.flutrackers.com/forum/showthread.php?p=15116&highlight=Kiselev#post15116
http://www.flutrackers.com/forum/showthread.php?p=65785&highlight=Kiselev#post65785

 

[Niko]

Re: Russian scientists evolve anti-bird flu drug

Previous reports/articles:

Scientists of the Institute of Organic Synthesis of the Ural branch of the Russian Academy of Science have developed a medicine to cure the most of virus infections, including the bird flu.
According to the director of the Institute, the academician V.Charushin, the trials of a new medicine "Triazoverin" are nearly finished. If clinical trials go down well, it is possible that as early as this autumn the industrial production of the Russian medicine for the bird flu will be launched. The most part of the synthesized powder is now kept in the St.-Petersburg scientific research institute of flu where it is tested on toxicity and safety.

Rossiiskaya Gazeta, 2.06.2006, ? the Remedy for all kinds of flu ?​

http://209.85.165.104/search?q=cach.../102.doc+triazoverin&hl=en&ct=clnk&cd=4&gl=us

04.04.2006

Ekaterinburg scientists have developed the cure for bird flu

?Repetition work of ?Triazoverin? preparation, which was developed by Ekaterinburg scientists for the treatment of the bird flu, could be started in the nearest future after clinical trials will be taken,? ? Valeriy Charushin, Academician, the Director of Institute of organic synthesis UrO RAS, has announced on the press-conference on Friday, March, 24. According to him, the repetition work of any preparation could be started only after the clinical trials were being taken during 1 year. Valeriy Charushin said that if Minzdravsotsrazvitiya of the Russian Federation approve the trials, they will be taken in Saint-Petersburg Institute of flu. After the trials will be completed, the place for the production of ?Triazoverin? will be chosen. Academician added that in case of the mass spread virus attacks, so called pandemic, the start of the production will not take much time, but will cost a lot. Serious investments will be needed, approximately hundreds million roubles. (API)


http://www.ekburg.ru/admeng/zdrav/30004_86161_0_1/



At a press conference on Tuesday 3 October [2006], Oleg Kiselev stated the following: "We obtained positive results for one of the three preparations. Triazoverin has passed all the stages of testing and will be put into production by the beginning of next year. Our vaccine is fundamentally new, which makes it competitive on the world market." The report went on to state that the Indonesian Embassy has already approached the Ministry of Education and Science about obtaining shipments of triazoverin to vaccinate Indonesia's population and that Turkey has also shown interest in the new preparation. Mr. Kiselev stated "Our main task is to make Russia a major exporter of influenza vaccines."
On 5 October, IA Inform-Ekologiya reported that clinical trials of triazoverin had begun at the Institute for Organic Synthesis of the Ural Branch of the Russian Academy of Sciences and preclinical trials had established the drug to be far superior to world preparations and to "handle H5N1 excellently." The report cited a JustMedia report quoting director of the Ural Scientific Research Institute for Veterinary Medicine Irina Donnik as stating that the tests were dragging on because of inadequate funding. Ms. Donnik added that the presidential plenipotentiary to the Ural Federal District has promised to support the project, and she stated that the institute was in the process of preparing a proposal detailing how much money was needed and exactly what it would be spent on. She expected the test results to be ready by New Year's and to receive the go-ahead to begin mass production of the preparation by summer. Ms. Donnik also explained that only the first stage of clinical trials will take place in Sverdlovsk Oblast. During the stage 1 trials, the drug will be tested on healthy poultry and on mice and rabbits, which will require several kilograms of the preparation. The second stage of the trials will occur at the All-Russian Scientific Research Institute for Immunology and Virology in the city of Pokrov in Vladimir Oblast. Those trials will evaluate triazoverin's effect on infected poultry. The All-Russian Scientific Research Institute for Immunology and Virology is one of only two institutions in Russia authorized to conduct such trials (the other being Vektor in Novosibirsk). The plan is to conduct the two stages of clinical trials in parallel with one another. The report went on to state that despite Oleg Kiselev's aforementioned assurances to reporters that the drug could be produced at a rate of 2 million doses in a week or 40 to 50 million in a year, experts were not even prepared to state where and when triazoverin will be produced.

http://www.xignite.com/xWorldNews.aspx?articleid=CEP20061009346001

 

[AlaskaDenise]

Re: Russian scientists evolve anti-bird flu drug

Since they're writing about both this drug killing a virus AND being a vaccination, this looks like a reporter interpretation issue again.

Does anyone know for sure which they're talking about?

.

 

[gsgs]

Re: Russian scientists evolve anti-bird flu drug

better wait for a non-Russian review...

 

[AlaskaDenise]

Re: Russian scientists evolve anti-bird flu drug

Another version.....

(snipped)

On 15 September, ITAR-TASS reported the start of clinical trials of a new avian flu drug that was developed by scientists the Ural Scientific Research Institute for Veterinary Medicine of the Russian Academy of Agricultural Sciences in Yekaterinburg. According to the institute's director Irina Donnik, if the new antiviral drug triazoverin proves effective in clinical trials, it would do away with the need to vaccinate birds. Ms. Donnik explained that her institute's specialists must first prove that the new drug is capable of boosting a healthy bird's immunity. She stated that if the anticipated effect is indeed documented, triazoverin will be used on sick poultry in 6 months' time. Triazoverin was developed by scientists at the Ural Institute for Organic Synthesis of the Ural Branch of the Russian Academy of Sciences. Work on the new drug actually began 20 years ago but was cut short. A year ago, the research was revived after scientists received a grant from the Russian Federation Ministry of Education and Science. According to academician Valeriy Charushian (the director of the Ural Institute for Organic Synthesis), triazoverin is a broad-spectrum drug that is capable of "conquering influenza A and B, herpes, and other infections." It has recently been proved that an avian flu strain is susceptible to triazoverin. The new drug has been characterized as nontoxic and harmless to humans.

http://www.xignite.com/xWorldNews.aspx?articleid=CEP20060918346001

 

[Niko]

Re: Russian scientists evolve anti-bird flu drug

When I couldn't find triazoverin at FT using the search function, I went ahead and posted the first article. Then, I searched via google for more info and found the other articles posted. I was hoping that someone would have more information and could clarify whether this is an anti-viral or vaccine.

The most part of the synthesized powder is now kept in the St.-Petersburg scientific research institute of flu where it is tested on toxicity and safety.

The above leads me to suspect it is an anti-viral. Anti-virals are often translated/misinterpreted as "vaccine". I don't recall ever seeing vaccine misinterpreted as anti-viral. Hopefully more information will be forthcoming or another member may have additional info.