tetano
Editor, Senior Moderator
Acta Biochim Pol. 2014 Sep 4. [Epub ahead of print]
Role of the host genetic variability in the influenza A virus susceptibility.
Arcanjo AC1, Mazzocco G2, de Oliveira SF1, Plewczynski D2, Radomski JP2.
Author information
Abstract
The aftermath of influenza infection is determined by a complex set of host-pathogen interactions, where genomic variability on both viral and host sides influences the final outcome. Although there exists large body of literature describing influenza virus variability, only a very small fraction covers the issue of host variance. The goal of this review is to explore the variability of host genes responsible for host-pathogen interactions, paying particular attention to genes responsible for the presence of sialylated glycans in the host endothelial membrane, mucus, genes used by viral immune escape mechanisms, and genes particularly expressed after vaccination, since they are more likely to have a direct influence on the infection outcome.
PMID:
25184407
[PubMed - as supplied by publisher]
Free full text
http://www.ncbi.nlm.nih.gov/pubmed/25184407
Role of the host genetic variability in the influenza A virus susceptibility.
Arcanjo AC1, Mazzocco G2, de Oliveira SF1, Plewczynski D2, Radomski JP2.
Author information
Abstract
The aftermath of influenza infection is determined by a complex set of host-pathogen interactions, where genomic variability on both viral and host sides influences the final outcome. Although there exists large body of literature describing influenza virus variability, only a very small fraction covers the issue of host variance. The goal of this review is to explore the variability of host genes responsible for host-pathogen interactions, paying particular attention to genes responsible for the presence of sialylated glycans in the host endothelial membrane, mucus, genes used by viral immune escape mechanisms, and genes particularly expressed after vaccination, since they are more likely to have a direct influence on the infection outcome.
PMID:
25184407
[PubMed - as supplied by publisher]
Free full text
http://www.ncbi.nlm.nih.gov/pubmed/25184407