tetano
Editor, Senior Moderator
J Virol. 2015 Sep 16. pii: JVI.01292-15. [Epub ahead of print]
[h=1]Role of Substitutions in the Hemagglutinin in the Emergence of the 1968 Pandemic Influenza Virus.[/h] Van Poucke S[SUP]1[/SUP], Doedt J[SUP]2[/SUP], Baumann J[SUP]2[/SUP], Qiu Y[SUP]1[/SUP], Matrosovich T[SUP]2[/SUP], Klenk HD[SUP]2[/SUP], Van Reeth K[SUP]3[/SUP], Matrosovich M[SUP]4[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Hemagglutinin (HA) of H3N2/1968 pandemic influenza viruses differed from putative avian precursor by seven amino acid substitutions. Substitutions Q226L and G228S are known to be essential for avian-to-mammalian adaptation. We found that introduction of avian-virus-like amino acids at five other HA positions (62, 81, 92, 144 and 193) of A/Hong Kong/1/1968 virus decreased viral replication in human cells and transmission in pigs. Thus, substitutions at some of these positions facilitated emergence of the pandemic virus.
Copyright ? 2015, American Society for Microbiology. All Rights Reserved.
PMID: 26378170 [PubMed - as supplied by publisher]
[h=1]Role of Substitutions in the Hemagglutinin in the Emergence of the 1968 Pandemic Influenza Virus.[/h] Van Poucke S[SUP]1[/SUP], Doedt J[SUP]2[/SUP], Baumann J[SUP]2[/SUP], Qiu Y[SUP]1[/SUP], Matrosovich T[SUP]2[/SUP], Klenk HD[SUP]2[/SUP], Van Reeth K[SUP]3[/SUP], Matrosovich M[SUP]4[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Hemagglutinin (HA) of H3N2/1968 pandemic influenza viruses differed from putative avian precursor by seven amino acid substitutions. Substitutions Q226L and G228S are known to be essential for avian-to-mammalian adaptation. We found that introduction of avian-virus-like amino acids at five other HA positions (62, 81, 92, 144 and 193) of A/Hong Kong/1/1968 virus decreased viral replication in human cells and transmission in pigs. Thus, substitutions at some of these positions facilitated emergence of the pandemic virus.
Copyright ? 2015, American Society for Microbiology. All Rights Reserved.
PMID: 26378170 [PubMed - as supplied by publisher]