Role for proteases and HLA-G in the pathogenicity of influenza A viruses

[tetano]

J Clin Virol. 2011 May 23. [Epub ahead of print]
Role for proteases and HLA-G in the pathogenicity of influenza A viruses.
Foucault ML, Moules V, Rosa-Calatrava M, Riteau B.
Source

CNRS FRE 3011 VirPath, Virologie et Pathologie Humaine, Facult? de m?decine RTH Laennec, Universit? Claude Bernard Lyon 1, Universit? de Lyon, F-69008 Lyon, France.
Abstract

Influenza is one of the most common infectious diseases in humans occurring as seasonal epidemic and sporadic pandemic outbreaks. The ongoing infections of humans with avian H5N1 influenza A viruses (IAV) and the past 2009 pandemic caused by the quadruple human/avian/swine reassortant (H1N1) virus highlights the permanent threat caused by these viruses. This review aims to describe the interaction between the virus and the host, with a particular focus on the role of proteases and HLA-G in the pathogenicity of influenza viruses.

Copyright ? 2011 Elsevier B.V. All rights reserved.

PMID:
21612979
[PubMed - as supplied by publisher]

http://www.ncbi.nlm.nih.gov/pubmed/21612979