tetano
Editor, Senior Moderator
J Pediatr (Rio J). 2013 Jul 8. pii: S0021-7557(13)00126-5. doi: 10.1016/j.jped.2013.01.010. [Epub ahead of print]
Risk factors for need of mechanical ventilation in children with Influenza A(H1N1)pdm09.
Scotta MC, Mattiello R, Marostica PJ, Jones MH, Martins LG, Fischer GB.
Source
MSc Candidate in Child and Adolescent Health, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil. Pediatric Infectious Disease's Specialist, Hospital da Crian?a Santo Antonio, Departamento de Pediatria, Porto Alegre, RS, Brazil. Electronic address: marcelo.scotta@ufrgs.br.
Abstract
OBJECTIVE:
The pandemic caused by influenza A(H1N1)pdm09 virus peaked between July and August of 2009 in southern Brazil, with the highest incidence in children and young adults. In the post-pandemic period, there was an increase in the incidence of cases during the winter months of 2011 and 2012 in Brazil, similar to seasonal influenza virus. Since infections due to pandemic influenza are still occurring, the present study aimed to investigate the risk factors for worse outcome in children.
METHODS:
A retrospective cohort study was performed by reviewing the charts of hospitalized patients younger than 14 years with reverse transcription-polymerase chain reaction (RT-PCR) positive for influenza A(H1N1)pdm09 during the first pandemic wave in six Brazilian tertiary centers. Need for mechanical ventilation was defined as the severity of outcome; age, chronic diseases, bacterial and viral co-detection, chest radiograph findings, and use of oseltamivir were possible predictors.
RESULTS:
In the present study, 120 patients were included. In a multivariate analysis, chronic diseases (prevalence ratio: 2.613, 95% CI: 1.267-5.386) and viral co-detection (prevalence ratio: 2.43, 95% CI: 1.203-4.905) were statistically associated with worse outcome (p<0.05).
CONCLUSIONS:
The presence of chronic diseases as predictors reinforces previous finding. Furthermore, viral co-detection was found to be a risk factor. Further studies are necessary to confirm this association.
Copyright ? 2013 Sociedade Brasileira de Pediatria. Published by Elsevier Editora Ltda. All rights reserved.
KEYWORDS:
Child, Crian?a, Fatores de risco, Influenza A H1N1 subtype, Influenza A subtipo H1N1, Insufici?ncia respirat?ria, Respiratory insufficiency, Risk factors
PMID:
23845706
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23845706
Risk factors for need of mechanical ventilation in children with Influenza A(H1N1)pdm09.
Scotta MC, Mattiello R, Marostica PJ, Jones MH, Martins LG, Fischer GB.
Source
MSc Candidate in Child and Adolescent Health, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil. Pediatric Infectious Disease's Specialist, Hospital da Crian?a Santo Antonio, Departamento de Pediatria, Porto Alegre, RS, Brazil. Electronic address: marcelo.scotta@ufrgs.br.
Abstract
OBJECTIVE:
The pandemic caused by influenza A(H1N1)pdm09 virus peaked between July and August of 2009 in southern Brazil, with the highest incidence in children and young adults. In the post-pandemic period, there was an increase in the incidence of cases during the winter months of 2011 and 2012 in Brazil, similar to seasonal influenza virus. Since infections due to pandemic influenza are still occurring, the present study aimed to investigate the risk factors for worse outcome in children.
METHODS:
A retrospective cohort study was performed by reviewing the charts of hospitalized patients younger than 14 years with reverse transcription-polymerase chain reaction (RT-PCR) positive for influenza A(H1N1)pdm09 during the first pandemic wave in six Brazilian tertiary centers. Need for mechanical ventilation was defined as the severity of outcome; age, chronic diseases, bacterial and viral co-detection, chest radiograph findings, and use of oseltamivir were possible predictors.
RESULTS:
In the present study, 120 patients were included. In a multivariate analysis, chronic diseases (prevalence ratio: 2.613, 95% CI: 1.267-5.386) and viral co-detection (prevalence ratio: 2.43, 95% CI: 1.203-4.905) were statistically associated with worse outcome (p<0.05).
CONCLUSIONS:
The presence of chronic diseases as predictors reinforces previous finding. Furthermore, viral co-detection was found to be a risk factor. Further studies are necessary to confirm this association.
Copyright ? 2013 Sociedade Brasileira de Pediatria. Published by Elsevier Editora Ltda. All rights reserved.
KEYWORDS:
Child, Crian?a, Fatores de risco, Influenza A H1N1 subtype, Influenza A subtipo H1N1, Insufici?ncia respirat?ria, Respiratory insufficiency, Risk factors
PMID:
23845706
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23845706