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Rhino virus turns killer in country?s north

Snowy Owl

Retired in 2010, In Memoriam
Rhino virus turns killer in country?s north
http://vietnamnews.vnagency.com.vn/showarticle.php?num=01HEA210208
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03-Virut.jpg
</TD></TR><TR><TD>Infants affected by virus Rhino A virus receive treatment at the National Paediatrics Hospital. ? VNA/VNS Photo Huu Oai</TD></TR></TBODY></TABLE>​
HA NOI ? Paediatricians have yet to find the best way to treat a Rhino virus that has killed nine of 19 infected infants in northern Viet Nam during the past two months.

Another six of the children ? all less than a year old ? have fallen seriously ill.

The virus was not normally dangerous and the children had died because they were not taken to hospital quickly enough, National Paediatrics Hospital deputy director Nguyen Van Loc said yesterday.

The hospital?s director, Nguyen Thanh Liem, said it was the first time the virus had caused acute pneumonia in Viet Nam.

The disease developed quickly and the damage done to the lungs was as critical as that of SARS, Severe Acute Respiratory Syndrome, he said.
"The virus infected many patients in the past, but we lacked the equipment to identify it," the director explained.
<TABLE cellPadding=2 width=200 align=right bgColor=#ffdfbf border=0><TBODY><TR><TD>
The world?s most
common cold
</TD></TR><TR><TD>
Rhino viruses are the world?s most common viral agents in humans and a causative agent of the common cold.
Of the 110 serologic virus types that cause cold symptoms rhino viruses are responsible for about 30 to 50 per cent.
There are two modes of transmission: via aerosols of respiratory droplets and from contaminated surfaces, including direct person-to-person contact.
Symptoms include sore throat, runny nose, nasal congestion, sneezing and coughing; sometimes accompanied by muscle aches, fatigue, malaise, headache, muscle weakness or loss of appetite.
Children may have six to twelve colds a year.
</TD></TR></TBODY></TABLE>​
"We did not give it much attention because no deaths were reported.

"But there was as yet no vaccine against the virus or medicines specific to its treatment.
"Physicians are using respirators, injecting them with the antibody globulin and medicines in an effort to save the stricken children."

The director said the hospital?s paediatricians now planned an on-line consultation with Japanese physicians in an effort to identify the best treatment.

Regarding possible causes for the fatalities, National Paediatrics Hospital deputy director Loc pointed to the prolonged cold spell and poor caring conditions.

He said, "All of the cases were of babies less than five-months-old, all of whom had fallen ill due to the harsh weather conditions.

The infants were not breast fed and lacked their mothers? care, causing their overall health to plummet, in effect making them more vulnerable to the virus."

Loc said that though these causes were inconclusive, they could be proved by the fact that none of the infected children had come from a family.

Most of the infected children are reported to have been from orphanages in Ha Tay, Bac Ninh and Bac Giang provinces and Ha Noi?s outlying Dong Anh District.

A hospital delegation that visited the Dong Anh orphanage before the lunar new year found that about 80 per cent of the children showed symptoms of the virus.

The physicians wanted to understand the reasons for the outbreak and devise methods for its treatment but they have not been able to identify why the virus has caused acute pneumonia in children.

The hospital?s Dr Pham Viet Hung said the Rhino virus was common throughout the world and was not new.

It accounted for more than 20 per cent of common colds and from one to five per cent of pneumonia in children.

It had not been thought of as deadly, he said. ? VNS
 
Re: Rhino virus turns killer in country?s north

Perhaps may be of interest this abstracts related to a novel rhinovirus isolated in patient with severe respiratory diseases.
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(1.4): J Infect Dis. 2007 Dec 15;196(12):1754-60.
Comment in:
J Infect Dis. 2007 Dec 15;196(12):1727-8.
A recently identified rhinovirus genotype is associated with severe respiratory-tract infection in children in Germany.

Renwick N, Schweiger B, Kapoor V, Liu Z, Villari J, Bullmann R, Miething R, Briese T, Lipkin WI.
Center for Infection and Immunity, Mailman School of Public Health, and College of Physicians and Surgeons, Columbia University, 722 W. 168th Street, New York, NY 10032, USA.

Acute respiratory infection is a significant cause of morbidity and mortality in children worldwide.

Accurate identification of causative agents is critical to case management and to prioritization in vaccine development.

Sensitive multiplex diagnostics provide us with an opportunity to investigate the relative contributions of individual agents and may also facilitate the discovery of new pathogens.

Recently, application of MassTag polymerase chain reaction (PCR) to undiagnosed influenza-like illness in New York State led to the discovery of a novel rhinovirus genotype.

Here we report the investigation, by MassTag PCR, of pediatric respiratory-tract infections in Germany, studying 97 cases for which no pathogen was identified through routine laboratory evaluation.

Respiratory viruses were identified in 49 cases (51%); of the 55 identified viruses, 41 (75%) were rhinoviruses.

The novel genotype represented 73% of rhinoviruses and 55% of all identified viruses.

Infections with the novel genotype were associated with upper-respiratory-tract symptoms but, more frequently, with bronchitis, bronchiolitis, and pneumonia.

PMID: 18190255 [PubMed - indexed for MEDLINE]
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