tetano
Editor, Senior Moderator
J Clin Virol. 2012 Oct 15. pii: S1386-6532(12)00359-9. doi: 10.1016/j.jcv.2012.09.012. [Epub ahead of print]
Rhino/enteroviruses in hospitalized children: A comparison to influenza viruses.
Messacar K, Robinson CC, Bagdure D, Curtis DJ, Glod? MP, Dominguez SR.
Source
Children's Hospital Colorado, Section of Infectious Diseases, B055, 13123 E 16th Avenue, Aurora, CO 80045, United States. Electronic address: kevin.messacar@childrenscolorado.org.
Abstract
BACKGROUND:
The relative impact of human rhino/enteroviruses (HRV/EV) compared to influenza viruses on hospitalized children is unknown.
OBJECTIVES:
This retrospective study compared the epidemiology and clinical characteristics of hospitalized patients with HRV/EV to patients hospitalized with influenza virus.
STUDY DESIGN:
Respiratory specimens from hospitalized children submitted between January 1, 2009 and December 31, 2009 to Children's Hospital Colorado Virology Laboratory in Aurora, CO were tested by a commercial multiplex PCR for 16 respiratory viruses and subtypes. Patients with specimens positive for HRV/EV or influenza virus without bacterial or viral co-infection were selected for retrospective chart review.
RESULTS:
Of the 2299 patients with specimens tested during the study period, 427 (18.6%) were singly positive for HRV/EV and 202 (8.8%) for influenza virus (p<0.01). Children with HRV/EV were more likely to present with increased work of breathing (67.9% vs. 52.5%, p<0.01) with crackles (36.3% vs. 23.3%, p<0.01) and wheezing (41.7% vs. 22.8%, p<0.01) noted on exam. Children hospitalized with HRV/EV had a shorter median length of stay (2 days vs. 3 days, p<0.01), duration of fever (1 days vs. 3 days, p<0.01), and duration of hypoxemia (2 days vs. 3 days, p<0.01) than children with influenza virus. Similar percentages of children with HRV/EV and influenza virus were admitted to the PICU and required positive pressure ventilation. There were no deaths in children hospitalized with HRV/EV, whereas 6 children with influenza virus expired.
CONCLUSIONS:
HRV/EVs are common pathogens in hospitalized children associated with serious lower respiratory tract disease and significant morbidity, similar to influenza viruses.
Copyright ? 2012 Elsevier B.V. All rights reserved.
PMID:
23078869
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23078869
Rhino/enteroviruses in hospitalized children: A comparison to influenza viruses.
Messacar K, Robinson CC, Bagdure D, Curtis DJ, Glod? MP, Dominguez SR.
Source
Children's Hospital Colorado, Section of Infectious Diseases, B055, 13123 E 16th Avenue, Aurora, CO 80045, United States. Electronic address: kevin.messacar@childrenscolorado.org.
Abstract
BACKGROUND:
The relative impact of human rhino/enteroviruses (HRV/EV) compared to influenza viruses on hospitalized children is unknown.
OBJECTIVES:
This retrospective study compared the epidemiology and clinical characteristics of hospitalized patients with HRV/EV to patients hospitalized with influenza virus.
STUDY DESIGN:
Respiratory specimens from hospitalized children submitted between January 1, 2009 and December 31, 2009 to Children's Hospital Colorado Virology Laboratory in Aurora, CO were tested by a commercial multiplex PCR for 16 respiratory viruses and subtypes. Patients with specimens positive for HRV/EV or influenza virus without bacterial or viral co-infection were selected for retrospective chart review.
RESULTS:
Of the 2299 patients with specimens tested during the study period, 427 (18.6%) were singly positive for HRV/EV and 202 (8.8%) for influenza virus (p<0.01). Children with HRV/EV were more likely to present with increased work of breathing (67.9% vs. 52.5%, p<0.01) with crackles (36.3% vs. 23.3%, p<0.01) and wheezing (41.7% vs. 22.8%, p<0.01) noted on exam. Children hospitalized with HRV/EV had a shorter median length of stay (2 days vs. 3 days, p<0.01), duration of fever (1 days vs. 3 days, p<0.01), and duration of hypoxemia (2 days vs. 3 days, p<0.01) than children with influenza virus. Similar percentages of children with HRV/EV and influenza virus were admitted to the PICU and required positive pressure ventilation. There were no deaths in children hospitalized with HRV/EV, whereas 6 children with influenza virus expired.
CONCLUSIONS:
HRV/EVs are common pathogens in hospitalized children associated with serious lower respiratory tract disease and significant morbidity, similar to influenza viruses.
Copyright ? 2012 Elsevier B.V. All rights reserved.
PMID:
23078869
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23078869