tetano
Editor, Senior Moderator
Rheumatology (Oxford)
. 2021 Oct 26;keab794.
doi: 10.1093/rheumatology/keab794. Online ahead of print.
COVID-19 Infection, Admission and Death Amongst People with Rare Autoimmune Rheumatic Disease in England. Results from the RECORDER Project
Megan Rutter[SUP] 1 2 [/SUP], Peter C Lanyon[SUP] 1 2 3 4 [/SUP], Matthew J Grainge[SUP] 1 [/SUP], Richard Hubbard[SUP] 1 4 [/SUP], Emily Peach[SUP] 1 [/SUP], Mary Bythell[SUP] 3 [/SUP], Peter Stilwell[SUP] 3 [/SUP], Jeanette Aston[SUP] 3 [/SUP], Sarah Stevens[SUP] 3 [/SUP], Fiona A Pearce[SUP] 1 2 3 4 [/SUP]
Affiliations
Abstract
Objectives: To calculate the rates of COVID-19 infection and COVID-19-related death among people with rare autoimmune rheumatic diseases (RAIRD) during the first wave of the COVID-19 pandemic in England compared with the general population.
Methods: We used Hospital Episode Statistics to identify all people alive 01 March 2020 with ICD-10 codes for RAIRD from the whole population of England. We used linked national health records (demographic, death certificate, admissions and PCR testing data) to calculate rates of COVID-19 infection and death up to 31 July 2020. Our primary definition of COVID-19-related death was mention of COVID-19 on the death certificate. General population data from Public Health England and the Office for National Statistics were used for comparison. We also describe COVID-19-related hospital admissions and all-cause deaths.
Results: We identified a cohort of 168 680 people with RAIRD, of whom 1874 (1.11%) had a positive COVID-19 PCR test. The age-standardised infection rate was 1.54 (95% CI 1.50-1.59) times higher than in the general population. 713 (0.42%) people with RAIRD died with COVID-19 on their death certificate and the age-sex-standardised mortality rate for COVID-19-related death was 2.41 (2.30-2.53) times higher than in the general population. There was no evidence of an increase in deaths from other causes in the RAIRD population.
Conclusions: During the first wave of COVID-19 in England, people with RAIRD had a 54% increased risk of COVID-19 infection and more than twice the risk of COVID-19-related death compared with the general population. These increases were seen despite shielding policies.
Keywords: COVID-19; coronavirus; epidemiology; infection; mortality; rare autoimmune rheumatic diseases; shielding.
. 2021 Oct 26;keab794.
doi: 10.1093/rheumatology/keab794. Online ahead of print.
COVID-19 Infection, Admission and Death Amongst People with Rare Autoimmune Rheumatic Disease in England. Results from the RECORDER Project
Megan Rutter[SUP] 1 2 [/SUP], Peter C Lanyon[SUP] 1 2 3 4 [/SUP], Matthew J Grainge[SUP] 1 [/SUP], Richard Hubbard[SUP] 1 4 [/SUP], Emily Peach[SUP] 1 [/SUP], Mary Bythell[SUP] 3 [/SUP], Peter Stilwell[SUP] 3 [/SUP], Jeanette Aston[SUP] 3 [/SUP], Sarah Stevens[SUP] 3 [/SUP], Fiona A Pearce[SUP] 1 2 3 4 [/SUP]
Affiliations
- PMID: 34698821
- DOI: 10.1093/rheumatology/keab794
Abstract
Objectives: To calculate the rates of COVID-19 infection and COVID-19-related death among people with rare autoimmune rheumatic diseases (RAIRD) during the first wave of the COVID-19 pandemic in England compared with the general population.
Methods: We used Hospital Episode Statistics to identify all people alive 01 March 2020 with ICD-10 codes for RAIRD from the whole population of England. We used linked national health records (demographic, death certificate, admissions and PCR testing data) to calculate rates of COVID-19 infection and death up to 31 July 2020. Our primary definition of COVID-19-related death was mention of COVID-19 on the death certificate. General population data from Public Health England and the Office for National Statistics were used for comparison. We also describe COVID-19-related hospital admissions and all-cause deaths.
Results: We identified a cohort of 168 680 people with RAIRD, of whom 1874 (1.11%) had a positive COVID-19 PCR test. The age-standardised infection rate was 1.54 (95% CI 1.50-1.59) times higher than in the general population. 713 (0.42%) people with RAIRD died with COVID-19 on their death certificate and the age-sex-standardised mortality rate for COVID-19-related death was 2.41 (2.30-2.53) times higher than in the general population. There was no evidence of an increase in deaths from other causes in the RAIRD population.
Conclusions: During the first wave of COVID-19 in England, people with RAIRD had a 54% increased risk of COVID-19 infection and more than twice the risk of COVID-19-related death compared with the general population. These increases were seen despite shielding policies.
Keywords: COVID-19; coronavirus; epidemiology; infection; mortality; rare autoimmune rheumatic diseases; shielding.