tetano
Editor, Senior Moderator
Rheumatol Int
. 2021 Jan 30.
doi: 10.1007/s00296-021-04792-9. Online ahead of print.
SARS-CoV-2 vaccines and autoimmune diseases amidst the COVID-19 crisis
Tsvetelina Velikova[SUP] 1 [/SUP], Tsvetoslav Georgiev[SUP] 2 3 [/SUP]
Affiliations
Abstract
Coronavirus disease 2019 (COVID-19) pandemic has become challenging even for the most durable healthcare systems. It seems that vaccination, one of the most effective public-health interventions, presents a ray of hope to end the pandemic by achieving herd immunity. In this review, we aimed to cover aspects of the current knowledge of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines and vaccine candidates in the light of autoimmune inflammatory diseases (AIIDs) and to analyze their potential in terms of safety and effectiveness in patients with AIIDs. Therefore, a focused narrative review was carried out to predict the possible implications of different types of SARS-CoV-2 vaccines which confer distinct immune mechanisms to establish immune response and protection against COVID-19: whole virus (inactivated or weakened), viral vector (replicating and non-replicating), nucleic acid (RNA, DNA), and protein-based (protein subunit, virus-like particle). Still, there is uncertainty among patients with AIIDs and clinicians about the effectiveness and safety of the new vaccines. There are a variety of approaches towards building a protective immunity against SARS-CoV-2. Only high-quality clinical trials would clarify the underlying immunological mechanisms of the newly implemented vaccines/adjuvants in patients living with AIIDs.
Keywords: Autoimmune diseases; COVID-19; COVID-19 vaccines; Messenger RNA; Rheumatic diseases; SARS-CoV-2; Vaccination.
. 2021 Jan 30.
doi: 10.1007/s00296-021-04792-9. Online ahead of print.
SARS-CoV-2 vaccines and autoimmune diseases amidst the COVID-19 crisis
Tsvetelina Velikova[SUP] 1 [/SUP], Tsvetoslav Georgiev[SUP] 2 3 [/SUP]
Affiliations
- PMID: 33515320
- DOI: 10.1007/s00296-021-04792-9
Abstract
Coronavirus disease 2019 (COVID-19) pandemic has become challenging even for the most durable healthcare systems. It seems that vaccination, one of the most effective public-health interventions, presents a ray of hope to end the pandemic by achieving herd immunity. In this review, we aimed to cover aspects of the current knowledge of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines and vaccine candidates in the light of autoimmune inflammatory diseases (AIIDs) and to analyze their potential in terms of safety and effectiveness in patients with AIIDs. Therefore, a focused narrative review was carried out to predict the possible implications of different types of SARS-CoV-2 vaccines which confer distinct immune mechanisms to establish immune response and protection against COVID-19: whole virus (inactivated or weakened), viral vector (replicating and non-replicating), nucleic acid (RNA, DNA), and protein-based (protein subunit, virus-like particle). Still, there is uncertainty among patients with AIIDs and clinicians about the effectiveness and safety of the new vaccines. There are a variety of approaches towards building a protective immunity against SARS-CoV-2. Only high-quality clinical trials would clarify the underlying immunological mechanisms of the newly implemented vaccines/adjuvants in patients living with AIIDs.
Keywords: Autoimmune diseases; COVID-19; COVID-19 vaccines; Messenger RNA; Rheumatic diseases; SARS-CoV-2; Vaccination.