tetano
Editor, Senior Moderator
Rev Med Virol
. 2021 Oct 13;e2304.
doi: 10.1002/rmv.2304. Online ahead of print.
The prevalence, predictors and outcomes of acute liver injury among patients with COVID-19: A systematic review and meta-analysis
Harapan Harapan[SUP] 1 2 3 [/SUP], Jonny Karunia Fajar[SUP] 4 [/SUP], Supriono Supriono[SUP] 5 [/SUP], Gatot Soegiarto[SUP] 6 [/SUP], Laksmi Wulandari[SUP] 7 [/SUP], Fiha Seratin[SUP] 8 [/SUP], Nyoman Gede Prayudi[SUP] 9 [/SUP], Dara Puspita Dewi[SUP] 10 [/SUP], Maria Theresia Monica Elsina[SUP] 11 [/SUP], Lasarus Atamou[SUP] 11 [/SUP], Sinta Wiranata[SUP] 12 [/SUP], Dhito Pemi Aprianto[SUP] 10 [/SUP], Erlin Friska[SUP] 13 [/SUP], D Fitria Sari Firdaus[SUP] 13 [/SUP], Makdum Alaidin[SUP] 14 [/SUP], Firdha Aprillia Wardhani[SUP] 15 [/SUP], Milda Husnah[SUP] 16 [/SUP], Nurdina Wahyu Hidayati[SUP] 15 [/SUP], Yeni Hendriyanti[SUP] 15 [/SUP], Kristia Wardani[SUP] 4 [/SUP], Arde Evatta[SUP] 4 [/SUP], Reizal Audi Manugan[SUP] 4 [/SUP], Wiryawan Pradipto[SUP] 4 [/SUP], Ade Rahmawati[SUP] 4 [/SUP], Fredo Tamara[SUP] 4 [/SUP], Aditya Indra Mahendra[SUP] 4 [/SUP], Firzan Nainu[SUP] 17 [/SUP], Budi Santoso[SUP] 18 [/SUP], Chandra Adi Irawan Primasatya[SUP] 19 [/SUP], Nindy Tjionganata[SUP] 20 [/SUP], Hendarto Arif Budiman[SUP] 19 [/SUP]
Affiliations
Abstract
The data on the predictors and prognosis of acute liver injury (ALI) among patients in coronavirus disease 2019 (COVID-19) patients are limited. The aim of this study was to determine the prevalence, predictors and outcomes of ALI among patients with COVID-19. A systematic review was conducted up to 10 June 2021. The relevant papers were searched from PubMed, Embase, Cochrane and Web of Science, and the data were analysed using a Z test. A total of 1331 papers were identified and 16 papers consisting of 1254 COVID-19 with ALI and 4999 COVID-19 without ALI were analysed. The cumulative prevalence of ALI among patients with COVID-19 was 22.8%. Male and having low lymphocyte levels were more likely to be associated with ALI compared with female and having higher lymphocyte level, odds ratio (OR): 2.70; 95% confidence interval (CI): 2.03, 3.60 and mean difference (MD) -125; 95% CI: -207, -43, respectively. COVID-19 patients with ALI had higher risk of developing severe COVID-19 compared with those without ALI (OR: 3.61; 95% CI: 2.60, 5.02). Our findings may serve as the additional evaluation for the management of ALI in COVID-19 patients.
Keywords: COVID-19; acute liver injury; outcome; predictor; prevalence.
. 2021 Oct 13;e2304.
doi: 10.1002/rmv.2304. Online ahead of print.
The prevalence, predictors and outcomes of acute liver injury among patients with COVID-19: A systematic review and meta-analysis
Harapan Harapan[SUP] 1 2 3 [/SUP], Jonny Karunia Fajar[SUP] 4 [/SUP], Supriono Supriono[SUP] 5 [/SUP], Gatot Soegiarto[SUP] 6 [/SUP], Laksmi Wulandari[SUP] 7 [/SUP], Fiha Seratin[SUP] 8 [/SUP], Nyoman Gede Prayudi[SUP] 9 [/SUP], Dara Puspita Dewi[SUP] 10 [/SUP], Maria Theresia Monica Elsina[SUP] 11 [/SUP], Lasarus Atamou[SUP] 11 [/SUP], Sinta Wiranata[SUP] 12 [/SUP], Dhito Pemi Aprianto[SUP] 10 [/SUP], Erlin Friska[SUP] 13 [/SUP], D Fitria Sari Firdaus[SUP] 13 [/SUP], Makdum Alaidin[SUP] 14 [/SUP], Firdha Aprillia Wardhani[SUP] 15 [/SUP], Milda Husnah[SUP] 16 [/SUP], Nurdina Wahyu Hidayati[SUP] 15 [/SUP], Yeni Hendriyanti[SUP] 15 [/SUP], Kristia Wardani[SUP] 4 [/SUP], Arde Evatta[SUP] 4 [/SUP], Reizal Audi Manugan[SUP] 4 [/SUP], Wiryawan Pradipto[SUP] 4 [/SUP], Ade Rahmawati[SUP] 4 [/SUP], Fredo Tamara[SUP] 4 [/SUP], Aditya Indra Mahendra[SUP] 4 [/SUP], Firzan Nainu[SUP] 17 [/SUP], Budi Santoso[SUP] 18 [/SUP], Chandra Adi Irawan Primasatya[SUP] 19 [/SUP], Nindy Tjionganata[SUP] 20 [/SUP], Hendarto Arif Budiman[SUP] 19 [/SUP]
Affiliations
- PMID: 34643006
- DOI: 10.1002/rmv.2304
Abstract
The data on the predictors and prognosis of acute liver injury (ALI) among patients in coronavirus disease 2019 (COVID-19) patients are limited. The aim of this study was to determine the prevalence, predictors and outcomes of ALI among patients with COVID-19. A systematic review was conducted up to 10 June 2021. The relevant papers were searched from PubMed, Embase, Cochrane and Web of Science, and the data were analysed using a Z test. A total of 1331 papers were identified and 16 papers consisting of 1254 COVID-19 with ALI and 4999 COVID-19 without ALI were analysed. The cumulative prevalence of ALI among patients with COVID-19 was 22.8%. Male and having low lymphocyte levels were more likely to be associated with ALI compared with female and having higher lymphocyte level, odds ratio (OR): 2.70; 95% confidence interval (CI): 2.03, 3.60 and mean difference (MD) -125; 95% CI: -207, -43, respectively. COVID-19 patients with ALI had higher risk of developing severe COVID-19 compared with those without ALI (OR: 3.61; 95% CI: 2.60, 5.02). Our findings may serve as the additional evaluation for the management of ALI in COVID-19 patients.
Keywords: COVID-19; acute liver injury; outcome; predictor; prevalence.