tetano
Editor, Senior Moderator
Rev Med Virol
. 2021 Jul 14;e2278.
doi: 10.1002/rmv.2278. Online ahead of print.
The impact of Parkinson's disease on manifestations and outcomes of Covid-19 patients: A systematic review and meta-analysis
Amr Ehab El-Qushayri[SUP] 1 [/SUP], Sherief Ghozy[SUP] 2 [/SUP], Abdullah Reda[SUP] 3 [/SUP], Ahmed Mostafa Ahmed Kamel[SUP] 4 [/SUP], Alzhraa Salah Abbas[SUP] 1 [/SUP], Adam A Dmytriw[SUP] 5 [/SUP]
Affiliations
Abstract
Parkinson's disease (PD) patients who contracted Coronavirus disease 2019 (Covid-19) had a decline in motor functions; nevertheless, there is limited evidence on whether PD patients have a higher risk for contracting Covid-19 or have worse outcomes. This is the first systematic review and meta-analysis to review the impact of PD on the prognosis of Covid-19 patients. We performed a systematic search through seven electronic databases under the recommendations of the Preferred Reporting Items for Systematic Review and Meta-analyses statement (PRISMA) guidelines. The R software version 4.0.2 was used to calculate pooled sample sizes and their associated confidence intervals (95%CI). Finally, we included 13 papers in this study. The pooled prevalence rate of Covid-19 was 2.12% (95%CI: 0.75-5.98). Fever, cough, fatigue and anorexia were the most common symptoms with a rate of 72.72% (95% CI: 57.3 - 92.29), 66.99% (95% CI: 49.08-91.42), 61.58% (95% CI: 46.69-81.21) and 52.55% (95% CI: 35.09-78.68), respectively. The pooled rates were 39.89% (95% CI: 27.09-58.73) for hospitalisation, 4.7% (95% CI: 1.56-14.16) for ICU admission and 25.1% (95%CI: 16.37-38.49) for mortality. On further comparison of hospitalisation and mortality rates among Covid-19 patients with and without PD, there were no significant differences. In conclusion, the prevalence and prognosis of Covid-19 patients seem comparable in patients with PD and those without it. The increased hospitalisation and mortality may be attributed to old age and co-morbidities.
Keywords: Covid-19; MLS; Parkinson's disease; SARS-CoV-2; length of stay; mortality.
. 2021 Jul 14;e2278.
doi: 10.1002/rmv.2278. Online ahead of print.
The impact of Parkinson's disease on manifestations and outcomes of Covid-19 patients: A systematic review and meta-analysis
Amr Ehab El-Qushayri[SUP] 1 [/SUP], Sherief Ghozy[SUP] 2 [/SUP], Abdullah Reda[SUP] 3 [/SUP], Ahmed Mostafa Ahmed Kamel[SUP] 4 [/SUP], Alzhraa Salah Abbas[SUP] 1 [/SUP], Adam A Dmytriw[SUP] 5 [/SUP]
Affiliations
- PMID: 34260773
- DOI: 10.1002/rmv.2278
Abstract
Parkinson's disease (PD) patients who contracted Coronavirus disease 2019 (Covid-19) had a decline in motor functions; nevertheless, there is limited evidence on whether PD patients have a higher risk for contracting Covid-19 or have worse outcomes. This is the first systematic review and meta-analysis to review the impact of PD on the prognosis of Covid-19 patients. We performed a systematic search through seven electronic databases under the recommendations of the Preferred Reporting Items for Systematic Review and Meta-analyses statement (PRISMA) guidelines. The R software version 4.0.2 was used to calculate pooled sample sizes and their associated confidence intervals (95%CI). Finally, we included 13 papers in this study. The pooled prevalence rate of Covid-19 was 2.12% (95%CI: 0.75-5.98). Fever, cough, fatigue and anorexia were the most common symptoms with a rate of 72.72% (95% CI: 57.3 - 92.29), 66.99% (95% CI: 49.08-91.42), 61.58% (95% CI: 46.69-81.21) and 52.55% (95% CI: 35.09-78.68), respectively. The pooled rates were 39.89% (95% CI: 27.09-58.73) for hospitalisation, 4.7% (95% CI: 1.56-14.16) for ICU admission and 25.1% (95%CI: 16.37-38.49) for mortality. On further comparison of hospitalisation and mortality rates among Covid-19 patients with and without PD, there were no significant differences. In conclusion, the prevalence and prognosis of Covid-19 patients seem comparable in patients with PD and those without it. The increased hospitalisation and mortality may be attributed to old age and co-morbidities.
Keywords: Covid-19; MLS; Parkinson's disease; SARS-CoV-2; length of stay; mortality.