tetano
Editor, Senior Moderator
Rev Med Virol
. 2020 Jul 30;e2135.
doi: 10.1002/rmv.2135. Online ahead of print.
Innate immune evasion by SARS-CoV-2: Comparison with SARS-CoV
Abdellatif Bouayad[SUP] 1 2 [/SUP]
Affiliations
Abstract
SARS-CoV-2 virus, a member of the Coronaviridae family, causes Covid-19 pandemic disease with severe respiratory illness. Multiple strategies enable SARS-CoV-2 to eventually overcome antiviral innate immune mechanisms which are important components of viral pathogenesis. This review considers several mechanisms of SARS-CoV-2 innate immune evasion including suppression of IFN-α/β production at the earliest stage of infection, mechanisms that exhaust natural killer cell-mediated cytotoxicity, overstimulation of NLRP3 inflammasome and induction of a cytokine storm. A comparison with SARS-CoV is made. Greater knowledge of these and other immune evasion tactics may provide us with improved possibilities for research into this novel deadly virus.
Keywords: IFN-α/β; NLRP3 inflammasome; SARS-CoV-2; coronaviruses; immune evasion; innate immunity.
. 2020 Jul 30;e2135.
doi: 10.1002/rmv.2135. Online ahead of print.
Innate immune evasion by SARS-CoV-2: Comparison with SARS-CoV
Abdellatif Bouayad[SUP] 1 2 [/SUP]
Affiliations
- PMID: 32734714
- DOI: 10.1002/rmv.2135
Abstract
SARS-CoV-2 virus, a member of the Coronaviridae family, causes Covid-19 pandemic disease with severe respiratory illness. Multiple strategies enable SARS-CoV-2 to eventually overcome antiviral innate immune mechanisms which are important components of viral pathogenesis. This review considers several mechanisms of SARS-CoV-2 innate immune evasion including suppression of IFN-α/β production at the earliest stage of infection, mechanisms that exhaust natural killer cell-mediated cytotoxicity, overstimulation of NLRP3 inflammasome and induction of a cytokine storm. A comparison with SARS-CoV is made. Greater knowledge of these and other immune evasion tactics may provide us with improved possibilities for research into this novel deadly virus.
Keywords: IFN-α/β; NLRP3 inflammasome; SARS-CoV-2; coronaviruses; immune evasion; innate immunity.