tetano
Editor, Senior Moderator
Rev Med Virol
. 2021 Sep 30;e2292.
doi: 10.1002/rmv.2292. Online ahead of print.
Cell death mechanisms involved in cell injury caused by SARS-CoV-2
Maríllya Morais da Silva[SUP] 1 [/SUP], André Silva Lira de Lucena[SUP] 1 [/SUP], Sergio de Sá Leitão Paiva Júnior[SUP] 2 [/SUP], Vanessa Mylenna Florêncio De Carvalho[SUP] 1 [/SUP], Priscilla Stela Santana de Oliveira[SUP] 1 [/SUP], Michelle Melgarejo da Rosa[SUP] 1 [/SUP], Moacyr Jesus Barreto de Melo Rego[SUP] 1 [/SUP], Maira Galdino da Rocha Pitta[SUP] 1 [/SUP], Michelly Cristiny Pereira[SUP] 1 [/SUP]
Affiliations
Abstract
Coronavirus disease 2019 (Covid-19) is an emerging novel respiratory infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that rapidly spread worldwide. In addition to lung injury, Covid-19 patients may develop extrapulmonary symptoms, including cardiac, liver, kidney, digestive tract, and neurological injuries. Angiotensin converting enzyme 2 is the major receptor for the entry of SARS-CoV-2 into host cells. The specific mechanisms that lead to cell death in different tissues during infection by SARS-CoV-2 remains unknown. Based on data of the previous human coronavirus SARS-CoV together with information about SARS-CoV-2, this review provides a summary of the mechanisms involved in cell death, including apoptosis, autophagy, and necrosis, provoked by severe acute respiratory syndrome coronavirus.
Keywords: Sars-CoV-2; cell death; pathways.
. 2021 Sep 30;e2292.
doi: 10.1002/rmv.2292. Online ahead of print.
Cell death mechanisms involved in cell injury caused by SARS-CoV-2
Maríllya Morais da Silva[SUP] 1 [/SUP], André Silva Lira de Lucena[SUP] 1 [/SUP], Sergio de Sá Leitão Paiva Júnior[SUP] 2 [/SUP], Vanessa Mylenna Florêncio De Carvalho[SUP] 1 [/SUP], Priscilla Stela Santana de Oliveira[SUP] 1 [/SUP], Michelle Melgarejo da Rosa[SUP] 1 [/SUP], Moacyr Jesus Barreto de Melo Rego[SUP] 1 [/SUP], Maira Galdino da Rocha Pitta[SUP] 1 [/SUP], Michelly Cristiny Pereira[SUP] 1 [/SUP]
Affiliations
- PMID: 34590761
- DOI: 10.1002/rmv.2292
Abstract
Coronavirus disease 2019 (Covid-19) is an emerging novel respiratory infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that rapidly spread worldwide. In addition to lung injury, Covid-19 patients may develop extrapulmonary symptoms, including cardiac, liver, kidney, digestive tract, and neurological injuries. Angiotensin converting enzyme 2 is the major receptor for the entry of SARS-CoV-2 into host cells. The specific mechanisms that lead to cell death in different tissues during infection by SARS-CoV-2 remains unknown. Based on data of the previous human coronavirus SARS-CoV together with information about SARS-CoV-2, this review provides a summary of the mechanisms involved in cell death, including apoptosis, autophagy, and necrosis, provoked by severe acute respiratory syndrome coronavirus.
Keywords: Sars-CoV-2; cell death; pathways.