tetano
Editor, Senior Moderator
Respirol Case Rep
. 2021 Oct 28;9(12):e0871.
doi: 10.1002/rcr2.871. eCollection 2021 Dec.
Post-coronavirus disease 2019 organizing pneumonia confirmed pathologically by video-assisted thoracoscopic surgery
Keishi Sugino[SUP] 1 [/SUP], Hirotaka Ono[SUP] 1 [/SUP], Shuji Haraguchi[SUP] 2 [/SUP], Seiji Igarashi[SUP] 3 [/SUP], Akira Hebisawa[SUP] 4 [/SUP], Eiyasu Tsuboi[SUP] 1 [/SUP]
Affiliations
Abstract
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2, has become a global pandemic. Many survivors of serious COVID-19 pneumonia have long-term residual pulmonary disease. However, there is little documentation of the histopathological characteristics of lung sequelae post-COVID-19 and effective treatments. We present two Japanese cases of lung sequelae post-COVID-19. The patients were histopathologically diagnosed with organizing pneumonia (OP) or OP with fibrosis and no diffuse alveolar damage on video-assisted thoracoscopic surgery. Case 1, who had been diagnosed with OP, was successfully treated with corticosteroid and other immunosuppressive agents over a 6-month period. Although case 2, who had been diagnosed with OP with fibrosis, had a partial and unsatisfactory response to immunosuppressive agents, the patient responded to antifibrotic treatment including nintedanib.
Keywords: coronavirus disease 2019; corticosteroid; organizing pneumonia; severe acute respiratory syndrome coronavirus 2; video‐assisted thoracoscopic surgery.
. 2021 Oct 28;9(12):e0871.
doi: 10.1002/rcr2.871. eCollection 2021 Dec.
Post-coronavirus disease 2019 organizing pneumonia confirmed pathologically by video-assisted thoracoscopic surgery
Keishi Sugino[SUP] 1 [/SUP], Hirotaka Ono[SUP] 1 [/SUP], Shuji Haraguchi[SUP] 2 [/SUP], Seiji Igarashi[SUP] 3 [/SUP], Akira Hebisawa[SUP] 4 [/SUP], Eiyasu Tsuboi[SUP] 1 [/SUP]
Affiliations
- PMID: 34745634
- PMCID: PMC8552080
- DOI: 10.1002/rcr2.871
Abstract
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2, has become a global pandemic. Many survivors of serious COVID-19 pneumonia have long-term residual pulmonary disease. However, there is little documentation of the histopathological characteristics of lung sequelae post-COVID-19 and effective treatments. We present two Japanese cases of lung sequelae post-COVID-19. The patients were histopathologically diagnosed with organizing pneumonia (OP) or OP with fibrosis and no diffuse alveolar damage on video-assisted thoracoscopic surgery. Case 1, who had been diagnosed with OP, was successfully treated with corticosteroid and other immunosuppressive agents over a 6-month period. Although case 2, who had been diagnosed with OP with fibrosis, had a partial and unsatisfactory response to immunosuppressive agents, the patient responded to antifibrotic treatment including nintedanib.
Keywords: coronavirus disease 2019; corticosteroid; organizing pneumonia; severe acute respiratory syndrome coronavirus 2; video‐assisted thoracoscopic surgery.