tetano
Editor, Senior Moderator
J Med Virol. 2019 Nov 26. doi: 10.1002/jmv.25640. [Epub ahead of print] [h=1]Respiratory viruses in individuals with high frequency of animal exposure in southern and highland Vietnam.[/h]
Nguyen TKT[SUP]1,[/SUP][SUP]2,[/SUP][SUP]3[/SUP], Ngo TT[SUP]2[/SUP], Tran MP[SUP]2[/SUP], Pham TTT[SUP]2[/SUP], Vu TTH[SUP]2[/SUP], Nguyen THN[SUP]2[/SUP], Thwaites G[SUP]2,[/SUP][SUP]4[/SUP], Virtala AK[SUP]5[/SUP], Vapalahti O[SUP]1,[/SUP][SUP]5,[/SUP][SUP]6[/SUP], Baker S[SUP]2,[/SUP][SUP]4,[/SUP][SUP]7[/SUP], Le VT[SUP]2[/SUP]; VIZIONS consortium.
[h=3]Author information[/h] 1 Faculty of Medicine, University of Helsinki, Finland. 2 Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam. 3 Dong Thap Provincial Center for Disease Control, Dong Thap Province, Vietnam. 4 Centre for Tropical Medicine and Global Health, Oxford University, Oxford, United Kingdom. 5 Department of Veterinary Biosciences, Faculty of Veterinary Medicine, University of Helsinki, Finland. 6 Virology and Immunology, HUSLAB, Helsinki University Hospital, Finland. 7 The Department of Medicine, University of Cambridge, Cambridge, United Kingdom.
[h=3]Abstract[/h] [h=4]INTRODUCTION:[/h] Active surveillance for zoonotic respiratory viruses is essential to inform the development of appropriate interventions and outbreak responses. Here we target individuals with high frequency of animal exposure in Vietnam.
[h=4]METHODS:[/h] A 3-year community-based surveillance was conducted in Vietnam during 2013-2016. We enrolled total of 581 individuals (animal-raising farmers, slaughterers, animal-health workers and rat-traders), and utilized RT-PCR to detect 15 common respiratory viruses in pooled nasal-throat swabs collected at baseline or acute respiratory-disease episodes.
[h=4]RESULTS:[/h] A respiratory virus was detected in 7.9% (58/732) of baseline samples, and 17.7% (136/770) of disease-episode samples (p<0.001), with enteroviruses, rhinoviruses and influenza A virus being the predominant viruses detected. There were temporal and spatial fluctuations in the frequencies of the detected viruses over the study period, e.g. enteroviruses and influenza A viruses were more often detected during rainy seasons.
[h=4]CONCLUSION:[/h] We reported the detection of common respiratory viruses in individuals with high frequency of animal exposure in Vietnam, an emerging infectious diseases hotspot. The results show the value of baseline/control sampling in delineating the causative relationships, and have revealed important insights into the ecological aspects of enteroviruses, rhinoviruses and influenza A and their contributions to the burden posed by respiratory infections in Vietnam. This article is protected by copyright. All rights reserved.
This article is protected by copyright. All rights reserved.
[h=4]KEYWORDS:[/h] Vietnam; asymptomatic; cohort study; respiratory disease; viral etiology; zoonoses
PMID: 31769525 DOI: 10.1002/jmv.25640
Nguyen TKT[SUP]1,[/SUP][SUP]2,[/SUP][SUP]3[/SUP], Ngo TT[SUP]2[/SUP], Tran MP[SUP]2[/SUP], Pham TTT[SUP]2[/SUP], Vu TTH[SUP]2[/SUP], Nguyen THN[SUP]2[/SUP], Thwaites G[SUP]2,[/SUP][SUP]4[/SUP], Virtala AK[SUP]5[/SUP], Vapalahti O[SUP]1,[/SUP][SUP]5,[/SUP][SUP]6[/SUP], Baker S[SUP]2,[/SUP][SUP]4,[/SUP][SUP]7[/SUP], Le VT[SUP]2[/SUP]; VIZIONS consortium.
[h=3]Author information[/h] 1 Faculty of Medicine, University of Helsinki, Finland. 2 Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam. 3 Dong Thap Provincial Center for Disease Control, Dong Thap Province, Vietnam. 4 Centre for Tropical Medicine and Global Health, Oxford University, Oxford, United Kingdom. 5 Department of Veterinary Biosciences, Faculty of Veterinary Medicine, University of Helsinki, Finland. 6 Virology and Immunology, HUSLAB, Helsinki University Hospital, Finland. 7 The Department of Medicine, University of Cambridge, Cambridge, United Kingdom.
[h=3]Abstract[/h] [h=4]INTRODUCTION:[/h] Active surveillance for zoonotic respiratory viruses is essential to inform the development of appropriate interventions and outbreak responses. Here we target individuals with high frequency of animal exposure in Vietnam.
[h=4]METHODS:[/h] A 3-year community-based surveillance was conducted in Vietnam during 2013-2016. We enrolled total of 581 individuals (animal-raising farmers, slaughterers, animal-health workers and rat-traders), and utilized RT-PCR to detect 15 common respiratory viruses in pooled nasal-throat swabs collected at baseline or acute respiratory-disease episodes.
[h=4]RESULTS:[/h] A respiratory virus was detected in 7.9% (58/732) of baseline samples, and 17.7% (136/770) of disease-episode samples (p<0.001), with enteroviruses, rhinoviruses and influenza A virus being the predominant viruses detected. There were temporal and spatial fluctuations in the frequencies of the detected viruses over the study period, e.g. enteroviruses and influenza A viruses were more often detected during rainy seasons.
[h=4]CONCLUSION:[/h] We reported the detection of common respiratory viruses in individuals with high frequency of animal exposure in Vietnam, an emerging infectious diseases hotspot. The results show the value of baseline/control sampling in delineating the causative relationships, and have revealed important insights into the ecological aspects of enteroviruses, rhinoviruses and influenza A and their contributions to the burden posed by respiratory infections in Vietnam. This article is protected by copyright. All rights reserved.
This article is protected by copyright. All rights reserved.
[h=4]KEYWORDS:[/h] Vietnam; asymptomatic; cohort study; respiratory disease; viral etiology; zoonoses
PMID: 31769525 DOI: 10.1002/jmv.25640