tetano
Editor, Senior Moderator
Clin Microbiol Infect. 2019 Apr 17. pii: S1198-743X(19)30183-1. doi: 10.1016/j.cmi.2019.04.012. [Epub ahead of print]
[h=1]Respiratory virus infection amongst hospitalized adult patients with or without clinically-apparent respiratory infection: a prospective cohort study.[/h] To KKW[SUP]1[/SUP], Chan KH[SUP]2[/SUP], Ho J[SUP]2[/SUP], Pang PKP[SUP]2[/SUP], Ho DTY[SUP]2[/SUP], Chang ACH[SUP]3[/SUP], Seng CW[SUP]3[/SUP], Yip CCY[SUP]4[/SUP], Cheng VCC[SUP]4[/SUP], Hung IFN[SUP]5[/SUP], Yuen KY[SUP]6[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]OBJECTIVES:[/h] We aimed to determine the viral epidemiology and clinical characteristics of patients with and those without clinically-apparent respiratory tract infection.
[h=4]METHODS:[/h] This prospective cohort study was conducted during the 2018 winter influenza season. Adult patients with fever/respiratory symptoms (fever/RS group) were age- and sex-matched with patients without fever/respiratory symptoms (non-fever/RS group) in a 1:1 ratio. Respiratory viruses were tested using NxTAG[SUP]TM[/SUP] Respiratory Pathogen Panel IVD, a commercially-available multiplex PCR panel.
[h=4]RESULTS:[/h] A total of 214 acutely hospitalized patients were included in the final analysis, consisting of 107 with fever/respiratory symptoms (fever/RS group), and 107 age- and sex-matched patients without fever/respiratory symptoms (non-fever/RS group). Respiratory viruses were detected in 34.1% (73/214) of patients, and coinfection occurred in 7.9% (17/214) of patients. The incidence of respiratory virus was higher in the fever/RS group than that in the non-fever/RS group (44.9% [48/107] vs 23.4% [25/107], P=0.001). Influenza B virus, enterovirus/rhinovirus and coronaviruses were detected more frequently in the fever/RS group, while parainfluenza virus 4B and adenovirus were detected more frequently in the non-fever/RS group. Among the non-fever/RS group, chest discomfort was more common among patients tested positive for respiratory viruses than those without respiratory virus detected (44% [11/25] vs 22% [18/82], P=0.04).
[h=4]CONCLUSIONS:[/h] Respiratory viruses can be frequently detected among hospitalized patients without typical features of respiratory tract infection. These patients may be a source of nosocomial outbreaks.
Copyright ? 2019 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. All rights reserved.
[h=4]KEYWORDS:[/h] Adenovirus; Cardiac complications; Influenza; Parainfluenza virus; Respiratory tract infection
PMID: 31004768 DOI: 10.1016/j.cmi.2019.04.012
[h=1]Respiratory virus infection amongst hospitalized adult patients with or without clinically-apparent respiratory infection: a prospective cohort study.[/h] To KKW[SUP]1[/SUP], Chan KH[SUP]2[/SUP], Ho J[SUP]2[/SUP], Pang PKP[SUP]2[/SUP], Ho DTY[SUP]2[/SUP], Chang ACH[SUP]3[/SUP], Seng CW[SUP]3[/SUP], Yip CCY[SUP]4[/SUP], Cheng VCC[SUP]4[/SUP], Hung IFN[SUP]5[/SUP], Yuen KY[SUP]6[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]OBJECTIVES:[/h] We aimed to determine the viral epidemiology and clinical characteristics of patients with and those without clinically-apparent respiratory tract infection.
[h=4]METHODS:[/h] This prospective cohort study was conducted during the 2018 winter influenza season. Adult patients with fever/respiratory symptoms (fever/RS group) were age- and sex-matched with patients without fever/respiratory symptoms (non-fever/RS group) in a 1:1 ratio. Respiratory viruses were tested using NxTAG[SUP]TM[/SUP] Respiratory Pathogen Panel IVD, a commercially-available multiplex PCR panel.
[h=4]RESULTS:[/h] A total of 214 acutely hospitalized patients were included in the final analysis, consisting of 107 with fever/respiratory symptoms (fever/RS group), and 107 age- and sex-matched patients without fever/respiratory symptoms (non-fever/RS group). Respiratory viruses were detected in 34.1% (73/214) of patients, and coinfection occurred in 7.9% (17/214) of patients. The incidence of respiratory virus was higher in the fever/RS group than that in the non-fever/RS group (44.9% [48/107] vs 23.4% [25/107], P=0.001). Influenza B virus, enterovirus/rhinovirus and coronaviruses were detected more frequently in the fever/RS group, while parainfluenza virus 4B and adenovirus were detected more frequently in the non-fever/RS group. Among the non-fever/RS group, chest discomfort was more common among patients tested positive for respiratory viruses than those without respiratory virus detected (44% [11/25] vs 22% [18/82], P=0.04).
[h=4]CONCLUSIONS:[/h] Respiratory viruses can be frequently detected among hospitalized patients without typical features of respiratory tract infection. These patients may be a source of nosocomial outbreaks.
Copyright ? 2019 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. All rights reserved.
[h=4]KEYWORDS:[/h] Adenovirus; Cardiac complications; Influenza; Parainfluenza virus; Respiratory tract infection
PMID: 31004768 DOI: 10.1016/j.cmi.2019.04.012