tetano
Editor, Senior Moderator
Respiration
. 2021 Sep 21;1-10.
doi: 10.1159/000518854. Online ahead of print.
Fatigue and Dyspnoea as Main Persistent Post-COVID-19 Symptoms in Previously Hospitalized Patients: Related Functional Limitations and Disability
César Fernández-de-Las-Peñas[SUP] 1 [/SUP], Domingo Palacios-Ceña[SUP] 1 [/SUP], Víctor Gómez-Mayordomo[SUP] 2 [/SUP], María Palacios-Ceña[SUP] 1 [/SUP], Jorge Rodríguez-Jiménez[SUP] 1 [/SUP], Ana I de-la-Llave-Rincón[SUP] 1 [/SUP], María Velasco-Arribas[SUP] 3 4 [/SUP], Stella Fuensalida-Novo[SUP] 1 [/SUP], Silvia Ambite-Quesada[SUP] 1 [/SUP], Carlos Guijarro[SUP] 3 4 [/SUP], María L Cuadrado[SUP] 2 5 [/SUP], Lidiane L Florencio[SUP] 1 [/SUP], José A Arias-Navalón[SUP] 6 [/SUP], Ricardo Ortega-Santiago[SUP] 1 [/SUP], Carlos M Elvira-Martínez[SUP] 2 [/SUP], Luis J Molina-Trigueros[SUP] 1 7 [/SUP], Juan Torres-Macho[SUP] 5 8 [/SUP], Tomas Sebastián-Viana[SUP] 7 [/SUP], María Gabriela Canto-Diez[SUP] 5 8 [/SUP], Margarita Cigarán-Méndez[SUP] 9 [/SUP], Valentín Hernández-Barrera[SUP] 10 [/SUP], Lars Arendt-Nielsen[SUP] 11 [/SUP]
Affiliations
Abstract
Background: Multicentre studies focussing on specific long-term post-COVID-19 symptoms are scarce.
Objective: The aim of this study was to determine the levels of fatigue and dyspnoea, repercussions on daily life activities, and risk factors associated with fatigue or dyspnoea in COVID-19 survivors at long term after hospital discharge.
Methods: Age, gender, height, weight, symptoms at hospitalization, pre-existing medical comorbidity, intensive care unit admission, and the presence of cardio-respiratory symptoms developed after severe acute respiratory syndrome coronavirus 2 infection were collected from patients who recovered from COVID-19 at 4 hospitals in Madrid (Spain) from March 1 to May 31, 2020 (first COVID-19 wave). The Functional Impairment Checklist was used for evaluating fatigue/dyspnoea levels and functional limitations.
Results: A total of 1,142 patients (48% women, age: 61, standard deviation [SD]: 17 years) were assessed 7.0 months (SD 0.6) after hospitalization. Fatigue was present in 61% patients, dyspnoea with activity in 55%, and dyspnoea at rest in 23.5%. Only 355 (31.1%) patients did not exhibit fatigue and/or dyspnoea 7 months after hospitalization. Forty-five per cent reported functional limitations with daily living activities. Risk factors associated with fatigue and dyspnoea included female gender, number of pre-existing comorbidities, and number of symptoms at hospitalization. The number of days at hospital was a risk factor just for dyspnoea.
Conclusions: Fatigue and/or dyspnoea were present in 70% of hospitalized COVID-19 survivors 7 months after discharge. In addition, 45% patients exhibited limitations on daily living activities. Being female, higher number of pre-existing medical comorbidities and number of symptoms at hospitalization were risk factors associated to fatigue/dyspnoea in COVID-19 survivors 7 months after hospitalization.
Keywords: COVID-19; Dyspnoea; Fatigue; Function; Risk factors.
. 2021 Sep 21;1-10.
doi: 10.1159/000518854. Online ahead of print.
Fatigue and Dyspnoea as Main Persistent Post-COVID-19 Symptoms in Previously Hospitalized Patients: Related Functional Limitations and Disability
César Fernández-de-Las-Peñas[SUP] 1 [/SUP], Domingo Palacios-Ceña[SUP] 1 [/SUP], Víctor Gómez-Mayordomo[SUP] 2 [/SUP], María Palacios-Ceña[SUP] 1 [/SUP], Jorge Rodríguez-Jiménez[SUP] 1 [/SUP], Ana I de-la-Llave-Rincón[SUP] 1 [/SUP], María Velasco-Arribas[SUP] 3 4 [/SUP], Stella Fuensalida-Novo[SUP] 1 [/SUP], Silvia Ambite-Quesada[SUP] 1 [/SUP], Carlos Guijarro[SUP] 3 4 [/SUP], María L Cuadrado[SUP] 2 5 [/SUP], Lidiane L Florencio[SUP] 1 [/SUP], José A Arias-Navalón[SUP] 6 [/SUP], Ricardo Ortega-Santiago[SUP] 1 [/SUP], Carlos M Elvira-Martínez[SUP] 2 [/SUP], Luis J Molina-Trigueros[SUP] 1 7 [/SUP], Juan Torres-Macho[SUP] 5 8 [/SUP], Tomas Sebastián-Viana[SUP] 7 [/SUP], María Gabriela Canto-Diez[SUP] 5 8 [/SUP], Margarita Cigarán-Méndez[SUP] 9 [/SUP], Valentín Hernández-Barrera[SUP] 10 [/SUP], Lars Arendt-Nielsen[SUP] 11 [/SUP]
Affiliations
- PMID: 34569550
- DOI: 10.1159/000518854
Abstract
Background: Multicentre studies focussing on specific long-term post-COVID-19 symptoms are scarce.
Objective: The aim of this study was to determine the levels of fatigue and dyspnoea, repercussions on daily life activities, and risk factors associated with fatigue or dyspnoea in COVID-19 survivors at long term after hospital discharge.
Methods: Age, gender, height, weight, symptoms at hospitalization, pre-existing medical comorbidity, intensive care unit admission, and the presence of cardio-respiratory symptoms developed after severe acute respiratory syndrome coronavirus 2 infection were collected from patients who recovered from COVID-19 at 4 hospitals in Madrid (Spain) from March 1 to May 31, 2020 (first COVID-19 wave). The Functional Impairment Checklist was used for evaluating fatigue/dyspnoea levels and functional limitations.
Results: A total of 1,142 patients (48% women, age: 61, standard deviation [SD]: 17 years) were assessed 7.0 months (SD 0.6) after hospitalization. Fatigue was present in 61% patients, dyspnoea with activity in 55%, and dyspnoea at rest in 23.5%. Only 355 (31.1%) patients did not exhibit fatigue and/or dyspnoea 7 months after hospitalization. Forty-five per cent reported functional limitations with daily living activities. Risk factors associated with fatigue and dyspnoea included female gender, number of pre-existing comorbidities, and number of symptoms at hospitalization. The number of days at hospital was a risk factor just for dyspnoea.
Conclusions: Fatigue and/or dyspnoea were present in 70% of hospitalized COVID-19 survivors 7 months after discharge. In addition, 45% patients exhibited limitations on daily living activities. Being female, higher number of pre-existing medical comorbidities and number of symptoms at hospitalization were risk factors associated to fatigue/dyspnoea in COVID-19 survivors 7 months after hospitalization.
Keywords: COVID-19; Dyspnoea; Fatigue; Function; Risk factors.