tetano
Editor, Senior Moderator
Respir Res
. 2020 Sep 21;21(1):241.
doi: 10.1186/s12931-020-01510-0.
The effect of vascular risk factor burden on the severity of COVID-19 illness, a retrospective cohort study
Houwei Du[SUP] 1 2 [/SUP], Xiaobin Pan[SUP] 3 [/SUP], Nan Liu[SUP] 4 5 [/SUP], Junnian Chen[SUP] 6 [/SUP], Xiaoling Chen[SUP] 7 [/SUP], David J Werring[SUP] 8 [/SUP], Gareth Ambler[SUP] 9 [/SUP], Xiaoqing Li[SUP] 10 [/SUP], Ronghua Chen[SUP] 4 11 [/SUP], Yixian Zhang[SUP] 5 [/SUP], Huayao Huang[SUP] 5 [/SUP], Feifei Lin[SUP] 4 [/SUP], Pincang Xia[SUP] 10 [/SUP], Chao Chen[SUP] 12 [/SUP], Zhenyang Zheng[SUP] 4 11 [/SUP], Sangru Wu[SUP] 4 [/SUP], Hanhan Lei[SUP] 4 [/SUP], Lei Gao[SUP] 13 [/SUP], Mingxu Huang[SUP] 14 [/SUP], Kexu Lin[SUP] 14 [/SUP], Xiaoping Xu[SUP] 15 [/SUP], Yukun Luo[SUP] 16 [/SUP], Ziwen Zhao[SUP] 16 [/SUP], Chen Li[SUP] 17 [/SUP], Hailong Lin[SUP] 18 [/SUP], Yu Lin[SUP] 19 [/SUP], Zhenghui Huang[SUP] 20 [/SUP], Rongxiang Cao[SUP] 20 [/SUP], Limin Chen[SUP] 20 [/SUP], Fujian Medical Team Support Wuhan for COVID-19
Affiliations
Abstract
Background: Patients with cardiovascular comorbidities are at high risk of poor outcome from COVID-19. However, how the burden (number) of vascular risk factors influences the risk of severe COVID-19 disease remains unresolved. Our aim was to investigate the association of severe COVID-19 illness with vascular risk factor burden.
Methods: We included 164 (61.8 ? 13.6 years) patients with COVID-19 in this retrospective study. We compared the difference in clinical characteristics, laboratory findings and chest computed tomography (CT) findings between patients with severe and non-severe COVID-19 illness. We evaluated the association between the number of vascular risk factors and the development of severe COVID-19 disease, using a Cox regression model.
Results: Sixteen (9.8%) patients had no vascular risk factors; 38 (23.2%) had 1; 58 (35.4%) had 2; 34 (20.7%) had 3; and 18 (10.9%) had ≥4 risk factors. Twenty-nine patients (17.7%) experienced severe COVID-19 disease with a median (14 [7-27] days) duration between onset to developing severe COVID-19 disease, an event rate of 4.47 per 1000-patient days (95%CI 3.10-6.43). Kaplan-Meier curves showed a gradual increase in the risk of severe COVID-19 illness (log-rank P < 0.001) stratified by the number of vascular risk factors. After adjustment for age, sex, and comorbidities as potential confounders, vascular risk factor burden remained associated with an increasing risk of severe COVID-19 illness.
Conclusions: Patients with increasing vascular risk factor burden have an increasing risk of severe COVID-19 disease, and this population might benefit from specific COVID-19 prevention (e.g., self-isolation) and early hospital treatment measures.
Keywords: Coronavirus disease 2019; Prognosis; Vascular risk factor.
. 2020 Sep 21;21(1):241.
doi: 10.1186/s12931-020-01510-0.
The effect of vascular risk factor burden on the severity of COVID-19 illness, a retrospective cohort study
Houwei Du[SUP] 1 2 [/SUP], Xiaobin Pan[SUP] 3 [/SUP], Nan Liu[SUP] 4 5 [/SUP], Junnian Chen[SUP] 6 [/SUP], Xiaoling Chen[SUP] 7 [/SUP], David J Werring[SUP] 8 [/SUP], Gareth Ambler[SUP] 9 [/SUP], Xiaoqing Li[SUP] 10 [/SUP], Ronghua Chen[SUP] 4 11 [/SUP], Yixian Zhang[SUP] 5 [/SUP], Huayao Huang[SUP] 5 [/SUP], Feifei Lin[SUP] 4 [/SUP], Pincang Xia[SUP] 10 [/SUP], Chao Chen[SUP] 12 [/SUP], Zhenyang Zheng[SUP] 4 11 [/SUP], Sangru Wu[SUP] 4 [/SUP], Hanhan Lei[SUP] 4 [/SUP], Lei Gao[SUP] 13 [/SUP], Mingxu Huang[SUP] 14 [/SUP], Kexu Lin[SUP] 14 [/SUP], Xiaoping Xu[SUP] 15 [/SUP], Yukun Luo[SUP] 16 [/SUP], Ziwen Zhao[SUP] 16 [/SUP], Chen Li[SUP] 17 [/SUP], Hailong Lin[SUP] 18 [/SUP], Yu Lin[SUP] 19 [/SUP], Zhenghui Huang[SUP] 20 [/SUP], Rongxiang Cao[SUP] 20 [/SUP], Limin Chen[SUP] 20 [/SUP], Fujian Medical Team Support Wuhan for COVID-19
Affiliations
- PMID: 32957997
- DOI: 10.1186/s12931-020-01510-0
Abstract
Background: Patients with cardiovascular comorbidities are at high risk of poor outcome from COVID-19. However, how the burden (number) of vascular risk factors influences the risk of severe COVID-19 disease remains unresolved. Our aim was to investigate the association of severe COVID-19 illness with vascular risk factor burden.
Methods: We included 164 (61.8 ? 13.6 years) patients with COVID-19 in this retrospective study. We compared the difference in clinical characteristics, laboratory findings and chest computed tomography (CT) findings between patients with severe and non-severe COVID-19 illness. We evaluated the association between the number of vascular risk factors and the development of severe COVID-19 disease, using a Cox regression model.
Results: Sixteen (9.8%) patients had no vascular risk factors; 38 (23.2%) had 1; 58 (35.4%) had 2; 34 (20.7%) had 3; and 18 (10.9%) had ≥4 risk factors. Twenty-nine patients (17.7%) experienced severe COVID-19 disease with a median (14 [7-27] days) duration between onset to developing severe COVID-19 disease, an event rate of 4.47 per 1000-patient days (95%CI 3.10-6.43). Kaplan-Meier curves showed a gradual increase in the risk of severe COVID-19 illness (log-rank P < 0.001) stratified by the number of vascular risk factors. After adjustment for age, sex, and comorbidities as potential confounders, vascular risk factor burden remained associated with an increasing risk of severe COVID-19 illness.
Conclusions: Patients with increasing vascular risk factor burden have an increasing risk of severe COVID-19 disease, and this population might benefit from specific COVID-19 prevention (e.g., self-isolation) and early hospital treatment measures.
Keywords: Coronavirus disease 2019; Prognosis; Vascular risk factor.