tetano
Editor, Senior Moderator
Respir Med
. 2021 May 13;184:106466.
doi: 10.1016/j.rmed.2021.106466. Online ahead of print.
SARS-CoV-2 infection in alpha1-antitrypsin deficiency
Carolin V Schneider[SUP] 1 [/SUP], Pavel Strnad[SUP] 2 [/SUP]
Affiliations
Abstract
Alpha1-antitrypsin deficiency arises due to mutations in alpha1-antitrypsin (AAT) gene and represents the most prominent genetic predisposition to chronic obstructive pulmonary disease and emphysema. Since AAT plays important immunomodulatory and tissue-protective roles and since it was suggested to protect from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, we assessed this association in United Kingdom Biobank, a community-based cohort with >500,000 participants. The most common, mild AATD genotypes were associated neither with increased SARS-CoV-2 infection rates nor with increased SARS-CoV-2 fatalities, while the numbers of severe AATD cases were too low to allow definitive conclusions.
Keywords: AAT; AATD; SARS-CoV2.
. 2021 May 13;184:106466.
doi: 10.1016/j.rmed.2021.106466. Online ahead of print.
SARS-CoV-2 infection in alpha1-antitrypsin deficiency
Carolin V Schneider[SUP] 1 [/SUP], Pavel Strnad[SUP] 2 [/SUP]
Affiliations
- PMID: 34010739
- DOI: 10.1016/j.rmed.2021.106466
Abstract
Alpha1-antitrypsin deficiency arises due to mutations in alpha1-antitrypsin (AAT) gene and represents the most prominent genetic predisposition to chronic obstructive pulmonary disease and emphysema. Since AAT plays important immunomodulatory and tissue-protective roles and since it was suggested to protect from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, we assessed this association in United Kingdom Biobank, a community-based cohort with >500,000 participants. The most common, mild AATD genotypes were associated neither with increased SARS-CoV-2 infection rates nor with increased SARS-CoV-2 fatalities, while the numbers of severe AATD cases were too low to allow definitive conclusions.
Keywords: AAT; AATD; SARS-CoV2.