tetano
Editor, Senior Moderator
Respir Med Case Rep
. 2020 Jul 6;31:101140.
doi: 10.1016/j.rmcr.2020.101140. eCollection 2020.
False negative SARS-CoV-2 PCR - A case report and literature review
Jessica Wiseman[SUP] 1 [/SUP], Timothy A D'Amico[SUP] 1 [/SUP], Sabina Zawadzka[SUP] 2 [/SUP], Henry Anyimadu[SUP] 3 [/SUP]
Affiliations
Abstract
The first case of the novel Coronavirus Diseases (COVID-19) caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) was detected in Wuhan, China in December 2019. On January 30, 2020, the World Health Organization declared a global health emergency. Countries around the world advised social distancing, businesses and schools closed, while health care workers faced a viral war. With the declaration of a global emergency, a test to rapidly detect the SARS-CoV-2 was developed to ensure swift isolation of infected persons to prevent spread of disease. Currently, the gold standard for test is Reverse Transcriptase Polymerase Chain Reaction (RT-PCR); however, patients with a high clinical suspicion for COVID-19 can sometimes have multiple negative tests. We discuss a patient under investigation (PUI) who had classic findings of COVID-19 but repeatedly tested negative from nasopharyngeal swabs until a fifth sample obtained from a deep suctioning was tested.
. 2020 Jul 6;31:101140.
doi: 10.1016/j.rmcr.2020.101140. eCollection 2020.
False negative SARS-CoV-2 PCR - A case report and literature review
Jessica Wiseman[SUP] 1 [/SUP], Timothy A D'Amico[SUP] 1 [/SUP], Sabina Zawadzka[SUP] 2 [/SUP], Henry Anyimadu[SUP] 3 [/SUP]
Affiliations
- PMID: 32714821
- PMCID: PMC7369610
- DOI: 10.1016/j.rmcr.2020.101140
Abstract
The first case of the novel Coronavirus Diseases (COVID-19) caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) was detected in Wuhan, China in December 2019. On January 30, 2020, the World Health Organization declared a global health emergency. Countries around the world advised social distancing, businesses and schools closed, while health care workers faced a viral war. With the declaration of a global emergency, a test to rapidly detect the SARS-CoV-2 was developed to ensure swift isolation of infected persons to prevent spread of disease. Currently, the gold standard for test is Reverse Transcriptase Polymerase Chain Reaction (RT-PCR); however, patients with a high clinical suspicion for COVID-19 can sometimes have multiple negative tests. We discuss a patient under investigation (PUI) who had classic findings of COVID-19 but repeatedly tested negative from nasopharyngeal swabs until a fifth sample obtained from a deep suctioning was tested.