tetano
Editor, Senior Moderator
Respir Investig
. 2023 Apr 19;61(4):454-459.
doi: 10.1016/j.resinv.2023.03.007. Online ahead of print. Use of the neutrophil-to-lymphocyte ratio and an oxygen requirement to predict disease severity in patients with COVID-19
Takuya Ozawa[SUP] 1 [/SUP], Takanori Asakura[SUP] 2 [/SUP], Shotaro Chubachi[SUP] 1 [/SUP], Ho Namkoong[SUP] 3 [/SUP], Hiromu Tanaka[SUP] 1 [/SUP], Ko Lee[SUP] 1 [/SUP], Takahiro Fukushima[SUP] 1 [/SUP], Shiro Otake[SUP] 1 [/SUP], Kensuke Nakagawara[SUP] 1 [/SUP], Mayuko Watase[SUP] 4 [/SUP], Katsunori Masaki[SUP] 1 [/SUP], Hirofumi Kamata[SUP] 1 [/SUP], Makoto Ishii[SUP] 1 [/SUP], Naoki Hasegawa[SUP] 3 [/SUP], Norihiro Harada[SUP] 5 [/SUP], Tetsuya Ueda[SUP] 6 [/SUP], Soichiro Ueda[SUP] 7 [/SUP], Takashi Ishiguro[SUP] 8 [/SUP], Ken Arimura[SUP] 9 [/SUP], Fukuki Saito[SUP] 10 [/SUP], Takashi Yoshiyama[SUP] 11 [/SUP], Yasushi Nakano[SUP] 12 [/SUP], Yoshikazu Mutoh[SUP] 13 [/SUP], Yusuke Suzuki[SUP] 14 [/SUP], Ryuya Edahiro[SUP] 15 [/SUP], Koji Murakami[SUP] 16 [/SUP], Yukinori Okada[SUP] 17 [/SUP], Ryuji Koike[SUP] 18 [/SUP], Yuko Kitagawa[SUP] 19 [/SUP], Katsushi Tokunaga[SUP] 20 [/SUP], Akinori Kimura[SUP] 21 [/SUP], Seiya Imoto[SUP] 22 [/SUP], Satoru Miyano[SUP] 23 [/SUP], Seishi Ogawa[SUP] 24 [/SUP], Takanori Kanai[SUP] 25 [/SUP], Koichi Fukunaga[SUP] 1 [/SUP]; Japan COVID-19 Task Force
Affiliations
We investigated the association between complete blood count, including neutrophil-to-lymphocyte ratio (NLR) in combination with patient characteristics, and coronavirus disease (COVID-19) outcomes to identify the best prognostic indicator. We analyzed data of patients with confirmed COVID-19 from the nationwide database of the Japan COVID-19 Task Force between February 2020 and November 2021. A composite outcome was defined as the most severe condition, including noninvasive positive-pressure ventilation, high-flow nasal cannula, invasive mechanical ventilation, extracorporeal membrane oxygenation, or death. Of 2425 patients in the analysis, 472 (19.5%) experienced a composite outcome. NLR was the best predictor of composite outcomes, with an area under the curve (AUC) of 0.81, and a sensitivity and specificity of 72.3% and 75.7%, respectively, using a cut-off value of 5.04. The combination of NLR and an oxygen requirement on admission had the highest AUC (0.88). This simple combination may help identify patients at risk of progression to severe disease.
Keywords: Area under the curve; COVID-19; Neutrophil-to-lymphocyte ratio; Prognostic indicator; SARS-CoV-2.
. 2023 Apr 19;61(4):454-459.
doi: 10.1016/j.resinv.2023.03.007. Online ahead of print. Use of the neutrophil-to-lymphocyte ratio and an oxygen requirement to predict disease severity in patients with COVID-19
Takuya Ozawa[SUP] 1 [/SUP], Takanori Asakura[SUP] 2 [/SUP], Shotaro Chubachi[SUP] 1 [/SUP], Ho Namkoong[SUP] 3 [/SUP], Hiromu Tanaka[SUP] 1 [/SUP], Ko Lee[SUP] 1 [/SUP], Takahiro Fukushima[SUP] 1 [/SUP], Shiro Otake[SUP] 1 [/SUP], Kensuke Nakagawara[SUP] 1 [/SUP], Mayuko Watase[SUP] 4 [/SUP], Katsunori Masaki[SUP] 1 [/SUP], Hirofumi Kamata[SUP] 1 [/SUP], Makoto Ishii[SUP] 1 [/SUP], Naoki Hasegawa[SUP] 3 [/SUP], Norihiro Harada[SUP] 5 [/SUP], Tetsuya Ueda[SUP] 6 [/SUP], Soichiro Ueda[SUP] 7 [/SUP], Takashi Ishiguro[SUP] 8 [/SUP], Ken Arimura[SUP] 9 [/SUP], Fukuki Saito[SUP] 10 [/SUP], Takashi Yoshiyama[SUP] 11 [/SUP], Yasushi Nakano[SUP] 12 [/SUP], Yoshikazu Mutoh[SUP] 13 [/SUP], Yusuke Suzuki[SUP] 14 [/SUP], Ryuya Edahiro[SUP] 15 [/SUP], Koji Murakami[SUP] 16 [/SUP], Yukinori Okada[SUP] 17 [/SUP], Ryuji Koike[SUP] 18 [/SUP], Yuko Kitagawa[SUP] 19 [/SUP], Katsushi Tokunaga[SUP] 20 [/SUP], Akinori Kimura[SUP] 21 [/SUP], Seiya Imoto[SUP] 22 [/SUP], Satoru Miyano[SUP] 23 [/SUP], Seishi Ogawa[SUP] 24 [/SUP], Takanori Kanai[SUP] 25 [/SUP], Koichi Fukunaga[SUP] 1 [/SUP]; Japan COVID-19 Task Force
Affiliations
- PMID: 37121116
- DOI: 10.1016/j.resinv.2023.03.007
We investigated the association between complete blood count, including neutrophil-to-lymphocyte ratio (NLR) in combination with patient characteristics, and coronavirus disease (COVID-19) outcomes to identify the best prognostic indicator. We analyzed data of patients with confirmed COVID-19 from the nationwide database of the Japan COVID-19 Task Force between February 2020 and November 2021. A composite outcome was defined as the most severe condition, including noninvasive positive-pressure ventilation, high-flow nasal cannula, invasive mechanical ventilation, extracorporeal membrane oxygenation, or death. Of 2425 patients in the analysis, 472 (19.5%) experienced a composite outcome. NLR was the best predictor of composite outcomes, with an area under the curve (AUC) of 0.81, and a sensitivity and specificity of 72.3% and 75.7%, respectively, using a cut-off value of 5.04. The combination of NLR and an oxygen requirement on admission had the highest AUC (0.88). This simple combination may help identify patients at risk of progression to severe disease.
Keywords: Area under the curve; COVID-19; Neutrophil-to-lymphocyte ratio; Prognostic indicator; SARS-CoV-2.