tetano
Editor, Senior Moderator
Respir Investig
. 2024 Aug 3;62(5):884-888.
doi: 10.1016/j.resinv.2024.07.016. Online ahead of print. SARS-CoV-2 co-detection with other respiratory pathogens-descriptive epidemiological study
Ken Arimura[SUP] 1 [/SUP], Ken Kikuchi[SUP] 2 [/SUP], Yasuto Sato[SUP] 3 [/SUP], Hitomi Miura[SUP] 4 [/SUP], Asako Sato[SUP] 5 [/SUP], Hideki Katsura[SUP] 6 [/SUP], Mitsuko Kondo[SUP] 6 [/SUP], Michio Itabashi[SUP] 7 [/SUP], Etsuko Tagaya[SUP] 6 [/SUP]
Affiliations
Background: Co-detection of respiratory pathogens with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is poorly understood. This descriptive epidemiological study aimed to determine the effect of the interaction of different respiratory pathogens on clinical variables.
Methods: We retrospectively reviewed the results of comprehensive multiplex polymerase chain reaction (PCR) testing from November 2020 to March 2023 to estimate respiratory pathogen co-detection rates in Shinjuku, Tokyo. We evaluated the interactions of respiratory pathogens, particularly SARS-CoV-2, between observed and expected co-detection. We estimated the trend of co-detection with SARS-CoV-2 in terms of age and sex and applied a multiple logistic regression model adjusted for age, testing period, and sex to identify influencing factors between co-detection and single detection for each pathogen.
Results: Among 57,746 patients who underwent multiplex PCR testing, 10,516 (18.2%) had positive for at least one of the 22 pathogens. Additionally, 881 (1.5%) patients were confirmed to have a co-detection. SARS-CoV-2 exhibited negative interactions with adenovirus, coronavirus, human metapneumovirus, parainfluenza virus, respiratory syncytial virus, and rhino/enterovirus. SARS-CoV-2 co-detection with other pathogens occurred most frequently in patients of the youngest age group (0-4 years). A multiple logistic regression model indicated that younger age was the most influential factor for SARS-CoV-2 co-detection with other respiratory pathogens.
Conclusion: The study highlights the prevalence of SARS-CoV-2 co-detection with other respiratory pathogens in younger age groups, necessitating further exploration of the clinical implications and severity of SARS-CoV-2 co-detection.
Keywords: FILMARRAY®; Multiplex PCR testing; SARS-CoV-2 co-detection; respiratory pathogens.
. 2024 Aug 3;62(5):884-888.
doi: 10.1016/j.resinv.2024.07.016. Online ahead of print. SARS-CoV-2 co-detection with other respiratory pathogens-descriptive epidemiological study
Ken Arimura[SUP] 1 [/SUP], Ken Kikuchi[SUP] 2 [/SUP], Yasuto Sato[SUP] 3 [/SUP], Hitomi Miura[SUP] 4 [/SUP], Asako Sato[SUP] 5 [/SUP], Hideki Katsura[SUP] 6 [/SUP], Mitsuko Kondo[SUP] 6 [/SUP], Michio Itabashi[SUP] 7 [/SUP], Etsuko Tagaya[SUP] 6 [/SUP]
Affiliations
- PMID: 39098246
- DOI: 10.1016/j.resinv.2024.07.016
Background: Co-detection of respiratory pathogens with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is poorly understood. This descriptive epidemiological study aimed to determine the effect of the interaction of different respiratory pathogens on clinical variables.
Methods: We retrospectively reviewed the results of comprehensive multiplex polymerase chain reaction (PCR) testing from November 2020 to March 2023 to estimate respiratory pathogen co-detection rates in Shinjuku, Tokyo. We evaluated the interactions of respiratory pathogens, particularly SARS-CoV-2, between observed and expected co-detection. We estimated the trend of co-detection with SARS-CoV-2 in terms of age and sex and applied a multiple logistic regression model adjusted for age, testing period, and sex to identify influencing factors between co-detection and single detection for each pathogen.
Results: Among 57,746 patients who underwent multiplex PCR testing, 10,516 (18.2%) had positive for at least one of the 22 pathogens. Additionally, 881 (1.5%) patients were confirmed to have a co-detection. SARS-CoV-2 exhibited negative interactions with adenovirus, coronavirus, human metapneumovirus, parainfluenza virus, respiratory syncytial virus, and rhino/enterovirus. SARS-CoV-2 co-detection with other pathogens occurred most frequently in patients of the youngest age group (0-4 years). A multiple logistic regression model indicated that younger age was the most influential factor for SARS-CoV-2 co-detection with other respiratory pathogens.
Conclusion: The study highlights the prevalence of SARS-CoV-2 co-detection with other respiratory pathogens in younger age groups, necessitating further exploration of the clinical implications and severity of SARS-CoV-2 co-detection.
Keywords: FILMARRAY®; Multiplex PCR testing; SARS-CoV-2 co-detection; respiratory pathogens.