tetano
Editor, Senior Moderator
Respir Investig
. 2023 Sep 12;61(6):733-737.
doi: 10.1016/j.resinv.2023.07.006. Online ahead of print. Effect of biologic therapy on the humoral immune response to the BNT162b2 vaccine in patients with asthma
Masahiro Shirata[SUP] 1 [/SUP], Isao Ito[SUP] 2 [/SUP], Tsuyoshi Oguma[SUP] 1 [/SUP], Tadao Nagasaki[SUP] 1 [/SUP], Issei Oi[SUP] 3 [/SUP], Nobuyoshi Hamao[SUP] 3 [/SUP], Kensuke Nishioka[SUP] 3 [/SUP], Toyohiro Hirai[SUP] 1 [/SUP]
Affiliations
The effect of inhaled corticosteroids (ICS) and biologics on the humoral immune response following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mRNA vaccination in patients with asthma is unknown. We prospectively evaluated the humoral immune response 3 weeks (T1) and 6 months (T2) after the second dose of BNT162b2 in 30 SARS-CoV-2-naïve patients with asthma. We measured anti-spike immunoglobulin G (IgG) titers and serum-neutralizing activity against the ancestral SARS-CoV-2 strain. The anti-spike IgG titer and neutralizing activity did not differ significantly between the biologics and non-biologics groups at T1 (P = 0.708 and P = 0.417, respectively) or T2 (P = 0.299 and P = 0.492, respectively). In the multivariate analysis, age and sex were significantly associated with the magnitude of the humoral immune response; however, the use of biologics and ICS dose were not, suggesting that these would not affect BNT162b2 immunogenicity in patients with asthma. Larger studies are needed to validate these findings.
Keywords: Asthma; Biologic agents; Immunogenicity; Inhaled corticosteroids; SARS-CoV-2 mRNA vaccine.
. 2023 Sep 12;61(6):733-737.
doi: 10.1016/j.resinv.2023.07.006. Online ahead of print. Effect of biologic therapy on the humoral immune response to the BNT162b2 vaccine in patients with asthma
Masahiro Shirata[SUP] 1 [/SUP], Isao Ito[SUP] 2 [/SUP], Tsuyoshi Oguma[SUP] 1 [/SUP], Tadao Nagasaki[SUP] 1 [/SUP], Issei Oi[SUP] 3 [/SUP], Nobuyoshi Hamao[SUP] 3 [/SUP], Kensuke Nishioka[SUP] 3 [/SUP], Toyohiro Hirai[SUP] 1 [/SUP]
Affiliations
- PMID: 37714091
- DOI: 10.1016/j.resinv.2023.07.006
The effect of inhaled corticosteroids (ICS) and biologics on the humoral immune response following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mRNA vaccination in patients with asthma is unknown. We prospectively evaluated the humoral immune response 3 weeks (T1) and 6 months (T2) after the second dose of BNT162b2 in 30 SARS-CoV-2-naïve patients with asthma. We measured anti-spike immunoglobulin G (IgG) titers and serum-neutralizing activity against the ancestral SARS-CoV-2 strain. The anti-spike IgG titer and neutralizing activity did not differ significantly between the biologics and non-biologics groups at T1 (P = 0.708 and P = 0.417, respectively) or T2 (P = 0.299 and P = 0.492, respectively). In the multivariate analysis, age and sex were significantly associated with the magnitude of the humoral immune response; however, the use of biologics and ICS dose were not, suggesting that these would not affect BNT162b2 immunogenicity in patients with asthma. Larger studies are needed to validate these findings.
Keywords: Asthma; Biologic agents; Immunogenicity; Inhaled corticosteroids; SARS-CoV-2 mRNA vaccine.