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Dr. Martin Richter (pharmacology), investigator with the Centre de recherche clinique ?tienne-Le Bel (CRCELB) at the Centre hospitalier universitaire de Sherbrooke (CHUS) and professor in the Faculty of Medicine and Health Sciences of the Universit? de Sherbrooke (UdeS), and his collaborators have identified a new function of the enzyme matriptase, present in the human respiratory system, that can activate a viral protein involved in infections caused by the H1N1 influenza (or flu) virus. Using this observation as a starting point, these researchers have discovered a new antiviral that targets the host rather than viruses, which could prevent viruses from acquiring drug resistance. Martin Richter's research findings provide a response to a critical need for new antivirals to treat the flu, which, even today, annually causes between 250,000 and 500,000 deaths across the world, especially among young children and the elderly.
