Researchers believe they have solved vaccine blood-clot puzzle ‘All mRNA-based vaccines should represent safe products,’ paper says

[Emily]

Researchers at the Goethe-University of Frankfurt and other sites explained that vaccines using a different technology known as messenger RNA (mRNA), such as those developed by BioNTech with Pfizer and Moderna, deliver the genetic material of the coronavirus spike protein only to fluid found inside cells, not to the nucleus of the cells.

“All mRNA-based vaccines should represent safe products,” the paper said.

It suggests vaccine makers using adenovirus vectors could modify the sequence of the spike protein “to avoid unintended splice reactions and to increase the safety of these pharmaceutical products.”

It comes as doctors in the UK have been urged to look for signs of stroke in people receiving the Oxford/AstraZeneca vaccine after three young patients were admitted to hospital and one died.


https://www.independent.co.uk/news/health/covid-vaccine-blood-clot-astrazeneca-b1854800.html
Researchers believe they have solved vaccine blood-clot puzzle


‘All mRNA-based vaccines should represent safe products,’ paper says

Samuel Osborne@SamuelOsborne93 2 days ago

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Researchers at the Goethe-University of Frankfurt and other sites explained that vaccines using a different technology known as messenger RNA (mRNA), such as those developed by BioNTech with Pfizer and Moderna, deliver the genetic material of the coronavirus spike protein only to fluid found inside cells, not to the nucleus of the cells.

“All mRNA-based vaccines should represent safe products,” the paper said.

It suggests vaccine makers using adenovirus vectors could modify the sequence of the spike protein “to avoid unintended splice reactions and to increase the safety of these pharmaceutical products.”

It comes as doctors in the UK have been urged to look for signs of stroke in people receiving the Oxford/AstraZeneca vaccine after three young patients were admitted to hospital and one died....

 

[Emily]

https://www.researchsquare.com/article/rs-558954/v1
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.

Research Article

“Vaccine-Induced Covid-19 Mimicry” Syndrome:
Splice reactions within the SARS-CoV-2 Spike open reading frame result in Spike protein variants that may cause thromboembolic events in patients immunized with vector-based vaccines

Eric Kowarz, Lea Krutzke, Jenny Reis, Silvia Bracharz, Stefan Kochanek, Rolf Marschalek

DOI: 10.21203/rs.3.rs-558954/v1

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During the last months many countries have started the immunization of millions of people by using vector-based vaccines. Unfortunately, severe side effects became overt during these vaccination campaigns: cerebral venous sinus thromboses (CVST), absolutely rare under normal life conditions, were found as a severe side effect that occured 4-14 days after first vaccinations. Besides CVST, Splanchnic Vein Thrombosis (SVT) was also observed. This type of adverse event has not been observed in the clinical studies of AstraZeneca, and therefore led immediately to a halt in vaccinations in several european countries. These events were mostly associated with thrombocytopenia, and thus, similar to the well-known Heparin-induced thrombo­cytopenia (HIT). Meanwhile, scientists have proposed a mechanism to explain this vaccine-induced thrombocytopenia. However, they do not provide a satisfactory explanation for the late thromboembolic events. Here, we present data that may explain these severe side effects which have been attributed to adenoviral vaccines. According to our results, transcription of wildtype and codon-optimized Spike open reading frames enables alternative splice events that lead to C-terminal truncated, soluble Spike protein variants. These soluble Spike variants may initiate severe side effects when binding to ACE2-expressing endothelial cells in blood vessels. In analogy to the thromboembolic events caused by Spike protein encoded by the SARS-CoV-2 virus, we termed the underlying disease mechanism the “Vaccine-Induced Covid-19 Mimicry” syndrome (VIC19M syndrome).
Keywords

Vector-based vaccines, CVST, SVT, thrombosis, splicing, Spike protein