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Research shows flu shots increase children's hospitalizations

appleblossom

Senior Moderator
Research shows flu shots increase children's hospitalizations; no sign of efficacy in flu prevention

July 14, 12:17 PM

Flu shots in children - do they help or harm?

As reported at the Natural News site, researchers presented at the 105th International Conference of the American Thoracic Society recently in San Diego, describing a study which showed that the flu vaccine is not effective in preventing influenza-related hospitalizations in children, including children with pre-existing asthma. The researchers found that children who got the flu vaccine were significantly more at risk for hospitalization than their peers who did not get the vaccine - the opposite of what they desired for the outcome of the research to be.

Scientist Avni Joshi, M.D., of the Mayo Clinic in Rochester, Minnesota, told the meeting, "The concerns that vaccination may be associated with asthma exacerbations have been disproved with multiple studies in the past, but the vaccine's effectiveness has not been well-established. This study was aimed at evaluating the effectiveness of the TIV (trivalent inactivated flu vaccine in children overall, as well as the children with asthma, to prevent influenza-related hospitalization."

Surprisingly, doctor Joshi then presented the results of the study, which appeared to show that the vaccine caused health problems serious enough to result in children being admitted to hospitals for care. To see if the vaccine reduced the number of hospitalizations for all children, especially those with asthma, over eight consecutive flu seasons, Dr. Joshi and the research team conducted a cohort study of 263 children. All the children had been evaluated at the Mayo Clinic in Minnesota between the ages of six months to 18 years and each had exhibited laboratory-confirmed flu between 1996 to 2006. The scientists documented which of the children in this cohort sample had been vaccinated with flu shots and which had not received flu shots. The children's asthma status was also noted along with records of which children did and did not require hospitalization.

Then the research team checked the records for each child subject to see who had been vaccinated before experiencing a flu-related episode that lead to a hospitalization for that illness. The results showed that children who had received the flu vaccine had three times the risk of hospitalization, as compared to children who had not received the vaccine. For those with asthma, there was even a higher risk of hospitalization in subjects who received the influenza shot. No other measured factors, which included insurance coverage status and severity of asthma, were found to correlate with risk of hospitalization.

Dr. Joshi neglected to find fault or express much concern with the flu shot, despite the data collected in this study. "While these findings do raise questions about the efficacy of the vaccine, they do not in fact implicate it as a cause of hospitalizations," Dr. Joshi said in a statement to the media. "More studies are needed to assess not only the immunogenicity, but also the efficacy of different influenza vaccines in asthmatic subjects." It appears that this physician is so committed to an apparent success with his research that he will blatantly lie about negative results that are openly visible to the audience. With this type of attitude among prominent physicians, how can parents trust doctors to recommend and administer truly safe and effective care to their children?

The CDC?s Advisory Committee on Immunization Practices (ACIP) and the American Academy of Pediatrics (AAP) recommend annual influenza vaccination for all children aged six months to 18 years. The National Asthma Education and Prevention Program (3rd revision) promotes annual flu vaccination of asthmatic children older than six months.

The hazards shown in published studies do not appear to concern these powerful organizations.

Meanwhile, as reported in a 2008 article at Natural News, there is a dearth of evidence to suggest that the shots work in preventing flu.

A large study reported in the Cochrane Database of Systematic Reviews of 260,000 children between ages 23 months and six years indicated that the flu vaccine is no more effective that a placebo.


http://www.examiner.com/x-12517-Miami-Holistic-Health-Examiner~y2009m7d14-Research-shows-flu-shots-increase-childrens-hospitalizations-no-sign-of-efficacy-in-flu-prevention
 
Re: Research shows flu shots increase children's hospitalizations

> children who had received the flu vaccine had three times the risk of hospitalization

uhh.
How often do they get infect, is that at least reduced ?

> A large study reported in the Cochrane Database of Systematic Reviews of 260,000
> children between ages 23 months and six years indicated that the flu vaccine is no more
> effective that a placebo.

link ? I remember one Cochrane survey where they concluded it's efficient, but not much


-----------edit-----------

http://erj.ersjournals.com/cgi/content/abstract/30/3/414
Influenza vaccination was associated with an unadjusted reduction in all-cause mortality during the three seasons of 50, 46 and 42%, respectively, which decreased to 14, 19 and 1%, respectively, following adjustment for confounders and differences in mortality between vaccinated and unvaccinated individuals following the influenza season. The numbers needed to treat to prevent one death, during the three seasons, were 297, 158 and 743, respectively

A report released by the Cochrane Collaboration in January 2006 concluded that there was no evidence that injecting children six to 23 months of age with the influenza vaccine was any more effective than a placebo. After a review of 51 studies involving more than 260,000 children, including 17 papers translated from Russian, the co-author of the study and coordinator of the Rome-based Cochrane Vaccine Project, Dr. Thomas Jefferson, concluded that mandates to vaccinate babies is based on very little evidence.5

http://www.ncbi.nlm.nih.gov/pubmed/...nel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

Influenza vaccines (especially two-dose live attenuated vaccines) are efficacious in children older than 2 years

http://www.ncbi.nlm.nih.gov/pubmed/...nel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum
AUTHORS' CONCLUSIONS: Influenza vaccines are efficacious in children older than two years but little evidence is available for children under two. There was a marked difference between vaccine efficacy and effectiveness
 
Re: Research shows flu shots increase children's hospitalizations

Leading author of the research paper:

Avni Y. Joshi, MD
joshi.avni@mayo.edu

American Thoracic Society Press Release:

Flu Shot Not Effective in Preventing Flu-Related Hospitalizations in Asthmatic Children (PDF)

http://www.thoracic.org/sections/publications/press-releases/conference/articles/2009/abstracts-and-press-releases/joshi.pdf

Another article:

Hospitalization Rates Higher in Kids Who Get Flu Shots

http://www.nlm.nih.gov/medlineplus/news/fullstory_84470.html
 
Re: Research shows flu shots increase children's hospitalizations

Just to throw out a thought on this research...

Could getting an influenza vaccine in children trigger a similar reaction to getting infected with dengue twice?

With dengue, it is possible that someone who gets infected a second time, with a different serotype can develop hemorhaggic fever, which is much worse than your regular dengue.

Could something similar be happening here...where a child gets a flu vaccine, then gets infected with a different strain that wasn't covered in the vaccine, which triggers ADE. I would be interested to know what the data says about the flu strain the patients had that were hospitalized versus what they were vaccinated against....
 
Re: Research shows flu shots increase children's hospitalizations

:confused: This does not make sense. A vaccine is simply a dead or weakened virus introduced to the body to activate an immediate response when the live virus is later encountered. It is simply prepping the body for invasion. How could children fare worse by having a dead virus followed by a live virus? Children who are not getting vaccines are getting subsequent infections with yearly flu's would have an equal chance of hospital admissions. Was this a double blind test to see if kids who were not vaccinated got asthma at elevated rates if they had the same infection twice? If this study is on the up and up and is not skewed in some way, then it has to be something else in the vaccine that is causing the severe illness when the virus is encountered a second time.
 
Re: Research shows flu shots increase children's hospitalizations

...where a child gets a flu vaccine, then gets infected with a different strain that wasn't covered in the vaccine....

Do we know how many of the serious H1N1 cases, those patients requiring hospitalization, or those who died, had seasonal flu vaccines last fall? Compared to mild cases?
 
Re: Research shows flu shots increase children's hospitalizations

Do we know how many of the serious H1N1 cases, those patients requiring hospitalization, or those who died, had seasonal flu vaccines last fall? Compared to mild cases?

I am not sure anyone has gathered that information...though I am of the opinion that it should be gathered to see if there is any correlation between virulence and exposure to a vaccine that had a different strain.
 
Re: Research shows flu shots increase children's hospitalizations

the virus infects killer-cells...
 
Re: Research shows flu shots increase children's hospitalizations

Take this one with a lot of skepticism folks. The source appears to have an anti-vaccine agenda:
Quote "Dr. Joshi neglected to find fault or express much concern with the flu shot, despite the data collected in this study. "While these findings do raise questions about the efficacy of the vaccine, they do not in fact implicate it as a cause of hospitalizations," Dr. Joshi said in a statement to the media. "More studies are needed to assess not only the immunogenicity, but also the efficacy of different influenza vaccines in asthmatic subjects." It appears that this physician is so committed to an apparent success with his research that he will blatantly lie about negative results that are openly visible to the audience. With this type of attitude among prominent physicians, how can parents trust doctors to recommend and administer truly safe and effective care to their children?"

I have not read the study, but would encourage interested persons to do so. The results could be explained by something as simple as the fact that high risk children, those with underlying health conditions (and therefore those most likely to be hospitalized regardless of vaccination status), are more likeley to be vaccinated than the general pediatric population.
 
Re: Research shows flu shots increase children's hospitalizations

I agree with Farmer and Shannon. I would like to see more hard, fact based science on this one.
My concern is that many parents will read stuff like this and choose not to vaccinate their kids. I'm not saying that some vaccines do not have bad points but compared to an H1N1 pandemic that mutates into a deadly form, I personally would go for the vaccine.
 
Even if this is true, overall risk of hospitalization could be less for general population if the shot is a good match (and seeking info from those with medical knowledge)

Even if this is true, overall risk of hospitalization could be less for general population if the shot is a good match (and seeking info from those with medical knowledge)

This does not make sense to me. However, IF it is correct, wouldn't flu hospitalizations still go down with vaccine?

Shouldn't the ultimate risk of hospitalization go down, because, in theory if the flu shot (in a good year match) prevents infection 70%-90% of the time in persons under 65.... and if you DO get it, the infection is usually less severe...(from CDC, number on statistics and severity studies on persons over 65) if, on the lower end, the shot is only 70% effective...

only 30 people who got the shot will get the flu out of 100

http://www.cdc.gov/FLU/about/qa/flushot.htm

Here is where I go into theory, I do not have numbers for the below, but it is based on statistics...
out of these, if 1 out of 100 unvaccinated would be hospitalized who got the flu (in theory), that would equal, without counting into account severity, .3 person out of each vaccinated hospitalized if there was no change at all in risk.

But even if this article were correct, .3 X 3X more likely to be hospitalized = .9, still less than 1. Not much on an individual level, but with actul numbers plugged in, any reduction in chance of being hospitalized sounds good to me. This does not account for the strain non-hospitalized infections put on health care systems, either.

I have asthma and so do my kids. Perhaps, in theory, your immune system causes an inflammation reaction without causing illness. This happens in asthma (inflammation when having the flu causing asthma) perhaps inflammation happens to some extent as well in everyone? (I am not a doctor, would love to know facts!) I could see, in theory, if you catch the flu before the inflammation goes down, and/or your immune system kicks in, an increase in hospitalization.

I, for one, would rather take the greater statistic odds for not getting sick at all, or having a slightly decreased risk of being hospitalized.

IF this article/study is accurate, I would, however, have to think about what to do, if the vaccine is not a good match and not preventing infection
 
Re: Research shows flu shots increase children's hospitalizations

Take this one with a lot of skepticism folks. The source appears to have an anti-vaccine agenda.

I don't want to pour gasoline on the vaccine/anti-vaccine argument, but the research was also reported in the same way by the American Thoracic Society and the National Institute of Health, who I assume are not anti-vaccine.

I'm not a doc or a scientist. I've read through the original abstract but don't understand medical-ese. The English translation as far as I understand it is that there is something in the seasonal flu vaccine which is dangerous for children and especially asthmatics, although which part of the vaccine is causing a bad reaction and why is not known.
 
Re: Research shows flu shots increase children's hospitalizations

Sorry to bash on about this - but if it is original antigenic sin - it makes perfect sense. Any viral infection will trigger an immune response and the body is just unable to recognize another virus at a later time as it is primed to fight the first virus, in this case the vaccine! This study has huge ramifications for vaccinations with a (probably) mismatched a/h1n1 vaccine.
 
Re: Research shows flu shots increase children's hospitalizations

I agree with Farmer and Shannon. I would like to see more hard, fact based science on this one.
My concern is that many parents will read stuff like this and choose not to vaccinate their kids. I'm not saying that some vaccines do not have bad points but compared to an H1N1 pandemic that mutates into a deadly form, I personally would go for the vaccine.

There are many people out there (me included) that will be hesitant to vaccinate for H1N1 (provided there even is a viable vaccine in the first place) for reasons other than this study, and not out of ignorance. Please don't assume that people who refuse vaccines don't know the difference between a bad study, a good study, and a body of evidence. (I'm not passing judgement on this study as I haven't read it).
 
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