tetano
Editor, Senior Moderator
Res Pract Thromb Haemost
. 2020 Jun 30;4(5):842-847.
doi: 10.1002/rth2.12376. eCollection 2020 Jul.
Venous thromboembolism in critically Ill patients with COVID-19: Results of a screening study for deep vein thrombosis
Alban Longchamp[SUP] 1 2 3 [/SUP], Justine Longchamp[SUP] 1 2 [/SUP], Sara Manzocchi-Besson[SUP] 2 4 [/SUP], Livia Whiting[SUP] 1 [/SUP], Claude Haller[SUP] 2 [/SUP], S?verin Jeanneret[SUP] 1 [/SUP], Manoelle Godio[SUP] 1 [/SUP], Juan Jose Garcia Martinez[SUP] 1 [/SUP], Thierry Bonjour[SUP] 1 [/SUP], Mary Caillat[SUP] 1 [/SUP], Guillaume Maitre[SUP] 1 [/SUP], Julian Matthias Thaler[SUP] 1 [/SUP], R?my Pantet[SUP] 1 [/SUP], Viviane Donner[SUP] 1 [/SUP], Alexis Dumoulin[SUP] 5 [/SUP], St?phane Emonet[SUP] 5 [/SUP], Gilbert Greub[SUP] 6 [/SUP], Raymond Friolet[SUP] 1 [/SUP], Helia Robert-Ebadi[SUP] 4 [/SUP], Marc Righini[SUP] 4 [/SUP], Bienvenido Sanchez[SUP] 1 [/SUP], Julie Delaloye[SUP] 1 [/SUP]
Affiliations
Abstract
Background: The rapid spread of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and coronavirus disease 2019 (COVID-19), has caused more than 3.9 million cases worldwide. Currently, there is great interest to assess venous thrombosis prevalence, diagnosis, prevention, and management in patients with COVID-19.
Objectives: To determine the prevalence of venous thromboembolism (VTE) in critically ill patients with COVID-19, using lower limbs venous ultrasonography screening.
Methods: Beginning March 8, we enrolled 25 patients who were admitted to the intensive care unit (ICU) with confirmed SARS-CoV-2 infections. The presence of lower extremity deep vein thrombosis (DVT) was systematically assessed by ultrasonography between day 5 and 10 after admission. The data reported here are those available up to May 9, 2020.
Results: The mean (? standard deviation) age of the patients was 68 ? 11 years, and 64% were men. No patients had a history of VTE. During the ICU stay, 8 patients (32%) had a VTE; 6 (24%) a proximal DVT, and 5 (20%) a pulmonary embolism. The rate of symptomatic VTE was 24%, while 8% of patients had screen-detected DVT. Only those patients with a documented VTE received a therapeutic anticoagulant regimen. As of May 9, 2020, 5 patients had died (20%), 2 remained in the ICU (8%), and 18 were discharged (72%).
Conclusions: In critically ill patients with SARS-CoV-2 infections, DVT screening at days 5-10 of admission yielded a 32% prevalence of VTE. Seventy-five percent of events occurred before screening. Earlier screening might be effective in optimizing care in ICU patients with COVID-19.
Keywords: COVID‐19; SARS virus; pulmonary embolism; ultrasonography; venous thrombosis.
. 2020 Jun 30;4(5):842-847.
doi: 10.1002/rth2.12376. eCollection 2020 Jul.
Venous thromboembolism in critically Ill patients with COVID-19: Results of a screening study for deep vein thrombosis
Alban Longchamp[SUP] 1 2 3 [/SUP], Justine Longchamp[SUP] 1 2 [/SUP], Sara Manzocchi-Besson[SUP] 2 4 [/SUP], Livia Whiting[SUP] 1 [/SUP], Claude Haller[SUP] 2 [/SUP], S?verin Jeanneret[SUP] 1 [/SUP], Manoelle Godio[SUP] 1 [/SUP], Juan Jose Garcia Martinez[SUP] 1 [/SUP], Thierry Bonjour[SUP] 1 [/SUP], Mary Caillat[SUP] 1 [/SUP], Guillaume Maitre[SUP] 1 [/SUP], Julian Matthias Thaler[SUP] 1 [/SUP], R?my Pantet[SUP] 1 [/SUP], Viviane Donner[SUP] 1 [/SUP], Alexis Dumoulin[SUP] 5 [/SUP], St?phane Emonet[SUP] 5 [/SUP], Gilbert Greub[SUP] 6 [/SUP], Raymond Friolet[SUP] 1 [/SUP], Helia Robert-Ebadi[SUP] 4 [/SUP], Marc Righini[SUP] 4 [/SUP], Bienvenido Sanchez[SUP] 1 [/SUP], Julie Delaloye[SUP] 1 [/SUP]
Affiliations
- PMID: 32685893
- PMCID: PMC7272794
- DOI: 10.1002/rth2.12376
Abstract
Background: The rapid spread of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and coronavirus disease 2019 (COVID-19), has caused more than 3.9 million cases worldwide. Currently, there is great interest to assess venous thrombosis prevalence, diagnosis, prevention, and management in patients with COVID-19.
Objectives: To determine the prevalence of venous thromboembolism (VTE) in critically ill patients with COVID-19, using lower limbs venous ultrasonography screening.
Methods: Beginning March 8, we enrolled 25 patients who were admitted to the intensive care unit (ICU) with confirmed SARS-CoV-2 infections. The presence of lower extremity deep vein thrombosis (DVT) was systematically assessed by ultrasonography between day 5 and 10 after admission. The data reported here are those available up to May 9, 2020.
Results: The mean (? standard deviation) age of the patients was 68 ? 11 years, and 64% were men. No patients had a history of VTE. During the ICU stay, 8 patients (32%) had a VTE; 6 (24%) a proximal DVT, and 5 (20%) a pulmonary embolism. The rate of symptomatic VTE was 24%, while 8% of patients had screen-detected DVT. Only those patients with a documented VTE received a therapeutic anticoagulant regimen. As of May 9, 2020, 5 patients had died (20%), 2 remained in the ICU (8%), and 18 were discharged (72%).
Conclusions: In critically ill patients with SARS-CoV-2 infections, DVT screening at days 5-10 of admission yielded a 32% prevalence of VTE. Seventy-five percent of events occurred before screening. Earlier screening might be effective in optimizing care in ICU patients with COVID-19.
Keywords: COVID‐19; SARS virus; pulmonary embolism; ultrasonography; venous thrombosis.