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[h=1][/h] The 3.8 ? resolution cryo-EM structure of Zika virus
Science 31 Mar 2016:
DOI: 10.1126/science.aaf5316
[h=2]Abstract[/h] The recent rapid spread of Zika virus and its unexpected linkage to birth defects and an autoimmune-neurological syndrome has generated worldwide concern. Zika virus is a flavivirus like dengue, yellow fever and West Nile viruses. We present the 3.8? resolution structure of mature Zika virus determined by cryo-electron microscopy. The structure of Zika virus is similar to other known flavivirus structures except for the ~10 amino acids that surround the Asn154 glycosylation site found in each of the 180 envelope glycoproteins that make up the icosahedral shell. The carbohydrate moiety associated with this residue, recognizable in the cryo-EM electron density, may function as an attachment site of the virus to host cells. This region varies not only among Zika virus strains but also in other flaviviruses and suggests that changes in this region influence virus transmission and disease.
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http://science.sciencemag.org/content/early/2016/03/30/science.aaf5316.full
[h=1][/h] The 3.8 ? resolution cryo-EM structure of Zika virus
- Devika Sirohi1,*,
- Zhenguo Chen1,*,
- Lei Sun1,
- Thomas Klose1,
- Theodore C. Pierson2,
- Michael G. Rossmann1,?,
- Richard J. Kuhn1,?
- 1Markey Center for Structural Biology and Purdue Institute for Inflammation, Immunology and Infectious Disease, Purdue University, West Lafayette, IN 47907, USA.
- 2Viral Pathogenesis Section, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
- ↵?Corresponding authors. E-mail: mr@purdue.edu (M.G.R); kuhnr@purdue (R.J.K)
- ↵* These authors contributed equally to this work.
Science 31 Mar 2016:
DOI: 10.1126/science.aaf5316
[h=2]Abstract[/h] The recent rapid spread of Zika virus and its unexpected linkage to birth defects and an autoimmune-neurological syndrome has generated worldwide concern. Zika virus is a flavivirus like dengue, yellow fever and West Nile viruses. We present the 3.8? resolution structure of mature Zika virus determined by cryo-electron microscopy. The structure of Zika virus is similar to other known flavivirus structures except for the ~10 amino acids that surround the Asn154 glycosylation site found in each of the 180 envelope glycoproteins that make up the icosahedral shell. The carbohydrate moiety associated with this residue, recognizable in the cryo-EM electron density, may function as an attachment site of the virus to host cells. This region varies not only among Zika virus strains but also in other flaviviruses and suggests that changes in this region influence virus transmission and disease.
...
http://science.sciencemag.org/content/early/2016/03/30/science.aaf5316.full