tetano
Editor, Senior Moderator
Influenza Other Respir Viruses. 2013 Dec;7 Suppl 4:90-3. doi: 10.1111/irv.12188.
Replication of avian influenza viruses in equine tracheal epithelium but not in horses.
Chambers TM, Balasuriya UB, Reedy SE, Tiwari A.
Source
Maxwell H. Gluck Equine Research Center, Department of Veterinary Science, University of Kentucky, Lexington, KY, USA.
Abstract
We evaluated a hypothesis that horses are susceptible to avian influenza viruses by in vitro testing, using explanted equine tracheal epithelial cultures, and in vivo testing by aerosol inoculation of ponies. Results showed that several subtypes of avian influenza viruses detectably replicated in vitro. Three viruses with high in vitro replication competence were administered to ponies. None of the three demonstrably replicated or caused disease signs in ponies. While these results do not exhaustively test our hypothesis, they do highlight that the tracheal explant culture system is a poor predictor of in vivo infectivity.
? 2013 Blackwell Publishing Ltd.
KEYWORDS:
Avian influenza, equine influenza, host range, interspecies transmission, organ culture
PMID:
24224824
[PubMed - in process]
http://www.ncbi.nlm.nih.gov/pubmed/24224824
Replication of avian influenza viruses in equine tracheal epithelium but not in horses.
Chambers TM, Balasuriya UB, Reedy SE, Tiwari A.
Source
Maxwell H. Gluck Equine Research Center, Department of Veterinary Science, University of Kentucky, Lexington, KY, USA.
Abstract
We evaluated a hypothesis that horses are susceptible to avian influenza viruses by in vitro testing, using explanted equine tracheal epithelial cultures, and in vivo testing by aerosol inoculation of ponies. Results showed that several subtypes of avian influenza viruses detectably replicated in vitro. Three viruses with high in vitro replication competence were administered to ponies. None of the three demonstrably replicated or caused disease signs in ponies. While these results do not exhaustively test our hypothesis, they do highlight that the tracheal explant culture system is a poor predictor of in vivo infectivity.
? 2013 Blackwell Publishing Ltd.
KEYWORDS:
Avian influenza, equine influenza, host range, interspecies transmission, organ culture
PMID:
24224824
[PubMed - in process]
http://www.ncbi.nlm.nih.gov/pubmed/24224824